Comparative Assessment of Different Dissolution Apparatus for Floating Drug Delivery Systems

Karande, A.D.; Yeole, Pramod

doi:10.14227/dt130106p20

Cited by 10 publications

(11 citation statements)

References 10 publications

(11 reference statements)

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“…Previous comparative studies of different dissolution apparatus (i.e. USP and non-USP) focused mainly on tablets (24,(29)(30)(31) and capsules (25,31,32). Only a few studies have dealt with active pharmaceutical ingredients (API) in the powdered form (23,33,34), and with limited scope, involving less than three apparatus.…”

Section: Introductionmentioning

confidence: 99%

What is a Suitable Dissolution Method for Drug Nanoparticles?

et al. 2008

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Section: Introductionmentioning

confidence: 99%

What is a Suitable Dissolution Method for Drug Nanoparticles?

et al. 2008

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“…Literature reports indicate that the modified dissolution apparatus can more closely simulate most of the in vivo conditions[1314]. …”

mentioning

confidence: 99%

Formulation and evaluation of floating drug delivery system of famotidine

Satishbabu¹,

V.Sandeep²,

Ravi³

et al. 2010

Indian J Pharm Sci

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A multiple unit oral floating drug delivery system of famotidine was developed to prolong gastric residence time, target stomach mucosa and increase drug bioavailability. Drug and polymer compatibility was studied by subjecting physical mixtures of drug and polymers to differential scanning calorimetry. Cod liver oil entrapped calcium alginate beads containing famotidine, capable of floating in the gastric condition were formulated and evaluated. The gel beads were prepared by emulsion gelation method by employing sodium alginate alone and mixture of sodium alginate and hydrophilic copolymers such as carbopol 934P and hydroxypropylmethylcellulose K15M grade in three different ratios. The effect of selected factors, such as percentage of oil and amount of copolymers on floating properties was investigated. The beads were evaluated for percent drug loading, drug entrapment efficiency, buoyancy and in vitro drug release. The in vitro drug release study of the beads was carried out in simulated gastric media employing a modified Rosette-Rice test apparatus. Wherein, the apparatus was further modified by incorporating a water jacket to the apparatus to circulate hot water to maintain 37±2° for throughout the release study. All the oil entrapped calcium alginate beads floated if a sufficient amount of oil was used. Beads formulated employing sodium alginate alone could not sustain the drug release up to 8 h, whereas beads formulated with mixture of sodium alginate and copolymers demonstrated sustained release of famotidine up to 8 h. The results suggested that cod liver oil entrapped calcium alginate beads were promising as a carrier for intragastric floating drug delivery of famotidine.

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“…However, this may be associated with a number of difficulties such as adherence of the tested product to the paddle shaft or sample withdrawal aid (pipette), incomplete exposure to the dissolution medium, and failure to predict in vivo performance (26). To overcome such problems, some researchers have alternatively used certain modifications to the paddle method (27,28), modified the dissolution apparatus (26,29,30), or used the FTC (USP Apparatus 4) (31).…”

Section: Pharmacokinetic Rationalementioning

confidence: 99%

In Vitro Release Evaluation of Gastroretentive Amoxicillin Floating Tablets Employing a Specific Design of the Flow-Through Cell

Emara¹,

Abdou²,

El-Ashmawy³

et al. 2013

Dissolution Technol.

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Floating amoxicillin trihydrate (AmoxT) tablets, used for eradication of Helicobacter pylori (H. pylori), were prepared according to a gas-generating technique to extend the drug residence time in the stomach. The drug release rate from the floating tablets in acidic dissolution medium, in which AmoxT is known to be unstable, was studied using two dissolution techniques: openloop system of the flow-through cell (FTC) and the beaker method. Analysis of AmoxT in the dissolution medium was carried out by UV spectrophotometric and HPLC methods. The comparison indicates that the open-loop system of the FTC, which is based on non-cumulative (fresh) dissolution samples, is the preferred dissolution technique, and in this case, the drug could be analyzed by UV spectrophotometric and HPLC methods. However, in the case of a large number of QC samples, UV spectrophotometry is preferred to the HPLC method, which requires relatively longer time for analysis thereby increasing drug degradation. On the other hand, in the case of the beaker method, which is based on cumulative dissolution samples, the drug must be analyzed by HPLC. Generally, the beaker method is not recommended due to the problems associated with the accumulation of AmoxT degradation product in the dissolution medium. This study describes a simple dissolution method capable of discriminating between different AmoxT gastroretentive formulations without any additional experimental or calculational steps.

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Comparative Assessment of Different Dissolution Apparatus for Floating Drug Delivery Systems

Cited by 10 publications

References 10 publications

What is a Suitable Dissolution Method for Drug Nanoparticles?

What is a Suitable Dissolution Method for Drug Nanoparticles?

Formulation and evaluation of floating drug delivery system of famotidine

In Vitro Release Evaluation of Gastroretentive Amoxicillin Floating Tablets Employing a Specific Design of the Flow-Through Cell

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