Comparative assessment of clinical profile and outcomes after primary percutaneous coronary intervention in young patients with single <i>vs</i> multivessel disease

Muhammad, Atif Sher; Ashraf, Tariq; Mir, Ayaz; Alishan, Syed; Farooq, Fatima; Ammar, Ali; Karim, Musa; Rizvi, Syed Nadeem Hassan; Saghir, Tahir; Sial, Jawaid Akbar; Khan, Naveed Ullah

doi:10.4330/wjc.v12.i4.136

Cited by 9 publications

(9 citation statements)

References 18 publications

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“…Hypertension was found to be an independent risk factor for multivessel disease in young ACS patients (male and female ≤ 45 years) (OR 3.63, 95% CI 1.88–7.01, p < 0.001). Multivessel disease was diagnosed in about 40.1% of young patients with STEMI and was associated with a poor outcome compared to single-vessel disease (38% vs. 25,1%, p < 0.01) [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review on the Risk Modulators of Myocardial Infarction in the “Young”—Implications of Lipoprotein (a)

Stătescu

Anghel

Benchea

et al. 2023

IJMS

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The presence of a myocardial infarction at a younger age is of special interest, considering the psychological and socioeconomic impact, as well as long-term morbidity and mortality. However, this group has a unique risk profile, with less traditional cardiovascular risk factors that are not well studied. This systematic review aims to evaluate traditional risk factors of myocardial infarction in the “young”, highlighting the clinical implications of lipoprotein (a). We performed a comprehensive search using Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) standards; we systematically searched the PubMed, EMBASE, and Science Direct Scopus databases, using the terms: “myocardial infarction”, “young”, “lipoprotein (a)”, “low-density lipoprotein”, “risk factors”. The search identified 334 articles which were screened, and, at the end, 9 original research articles regarding the implications of lipoprotein (a) in myocardial infarction in the “young” were included in the qualitative synthesis. Elevated lipoprotein (a) levels were independently associated with an increased risk of coronary artery disease, especially in young patients, where this risk increased by threefold. Thus, it is recommended to measure the lipoprotein (a) levels in individuals with suspected familial hypercholesterolaemia or with premature atherosclerotic cardiovascular disease and no other identifiable risk factors, in order to identify patients who might benefit from a more intensive therapeutic approach and follow-up.

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Section: Resultsmentioning

confidence: 99%

“…Independent risk factor for multivessel disease in younger ACS patients (≤45 years) with a poor outcome [ 17 ]…”

Section: Figurementioning

confidence: 99%

A Systematic Review on the Risk Modulators of Myocardial Infarction in the “Young”—Implications of Lipoprotein (a)

Stătescu

Anghel

Benchea

et al. 2023

IJMS

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“…According to two studies, approximately 13.3% 41 and 25.0% 13 of Nepalese patients had a high BMI, respectively. Pakistani patients were reported to have high BMI that ranged from 15.6% 42 to 97.1% 40 , and up to 60.7% 11 of Bangladeshi patients had a high BMI. Similarly, the proportion of patients with high BMI ranged from as low as 1.7% 39 to as high as 69.0% 43 in India, according to 24 studies.…”

Section: Resultsmentioning

confidence: 99%

Risk factors, lab parameters, angiographic characteristics and outcomes of coronary artery disease in young South Asian patients: a systematic review

Agrawal,

Lamichhane,

Eghbali

et al. 2023

J Int Med Res

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This systematic review provides a qualitative summary of the risk factors, angiographic characteristics, treatment, and complications of young South Asians with coronary artery disease (CAD). PubMed, Embase, and Google Scholar were searched to identify research articles published between 1 January 2010 and 13 November 2022. Studies in patients aged 18 to 45 years that were conducted in South Asian countries, were published in the English language, and included information on patients’ clinical profiles and at least two risk factors for young CAD were included in the review. Smoking, dyslipidemia, high body mass index, increased high-sensitivity C-reactive protein, and hyperhomocysteinemia were observed in high proportions in young patients with CAD. Single-vessel disease was more common than multi-vessel disease in young CAD. The complications of CAD such as arrhythmias, cardiogenic shock, and heart failure were also commonly observed in young patients. Large-scale health promotion activities that curb modifiable risk factors such as smoking, obesity, and a sedentary lifestyle should be conducted in South Asian countries.

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“…Multivessel disease (MVD) was less common in young patients, it account for only about 1/3rd of the total patients, which was smaller than some of the past studies on STEMI patients in Pakistani population. Muhammad AS et al 20 reported MVD in 40.1% of the patients with STEMI under 45 years of age. Similarly, in a study by Batra MK et al 1 MVD was reported in 38% of young (≤ 40 years) patients with STEMI.…”

Section: Discussionmentioning

confidence: 98%

Pattern of Coronary Artery Diseases in Patients Under 40 Years of Age With Acute Coronary Syndrome

et al. 2021

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Objectives: To determine the pattern of coronary artery diseases (CAD) in patients under 40 years of age with acute coronary syndrome (ACS) presenting at Hyderabad Satellite Center of National Institute of Cardiovascular Disease (NICVD), Pakistan. Methodology: This cross-sectional study was conducted at cardiology department of the NICVD, Hyderabad Satellite Center. Both male and female patients, between 18 to 40 years of age, diagnosed with acute coronary syndrome (ACS), and undergone coronary angiography were included in this study. Angiographic patterns in terms of extent of the disease (number of diseased vessels and localization of lesion) were assessed. Results: Total of 220 young patients included. Patients were predominantly male (91.8%) with the mean age of 35.3 ± 5 years. Smoking was observed 30.5% followed by hypertension (24.5%) and positive family history of CAD (19.1%). A majority of the patients (79.1%) were diagnosed as with ST-elevation myocardial infarction (STEMI) with anterior wall myocardial infarction (MI) as the most common (57.3%) type of MI. Most of the patients (70%) had single vessel diseases (SVD) with left anterior descending artery (LAD) as the most commonly diseases vessel (53.6%). Nine (4.1%) patients had significant left main disease and 6.4% had non-obstructive CAD. Conclusion: The common clinical presentation of ACS in younger patients is STEMI. Smoking is the commonest risk factor followed by hypertension and family history of CAD. More than 2/3rd of the young patients are expected to have single vessel diseases with LAD as the most commonly diseased vessel.

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Comparative assessment of clinical profile and outcomes after primary percutaneous coronary intervention in young patients with single vs multivessel disease

Cited by 9 publications

References 18 publications

A Systematic Review on the Risk Modulators of Myocardial Infarction in the “Young”—Implications of Lipoprotein (a)

A Systematic Review on the Risk Modulators of Myocardial Infarction in the “Young”—Implications of Lipoprotein (a)

Risk factors, lab parameters, angiographic characteristics and outcomes of coronary artery disease in young South Asian patients: a systematic review

Pattern of Coronary Artery Diseases in Patients Under 40 Years of Age With Acute Coronary Syndrome

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