2017
DOI: 10.1111/jnc.14016
|View full text |Cite
|
Sign up to set email alerts
|

Comparative assessment of 6‐[18F]fluoro‐L‐m‐tyrosine and 6‐[18F]fluoro‐L‐dopa to evaluate dopaminergic presynaptic integrity in a Parkinson's disease rat model

Abstract: Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson's disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical importance in the preclinical evaluation of highly awaited disease-modifying therapies. Among existing methods, the high sensitivity of positron emission tomography (PET) is attractive to achieve that goal. The aim of this study was to perform a quantitative comparison of brain images obtained in 6-hydroxydop… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

0
9
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
4
2
1

Relationship

0
7

Authors

Journals

citations
Cited by 17 publications
(9 citation statements)
references
References 37 publications
0
9
0
Order By: Relevance
“…As such, metabolites can cross the blood-brain-barrier and will distribute throughout the brain in a uniform fashion. This enhances background noise relative to the use of for example [ 18 F]FMT, which is not a substrate for COMT (Becker et al, 2017), leading to a lower signal-to-noise ratio. It should be noted that this would mainly be a concern when the regions of interests are located in brain areas with low dopamine levels, but less so in the dopamine-rich striatum.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…As such, metabolites can cross the blood-brain-barrier and will distribute throughout the brain in a uniform fashion. This enhances background noise relative to the use of for example [ 18 F]FMT, which is not a substrate for COMT (Becker et al, 2017), leading to a lower signal-to-noise ratio. It should be noted that this would mainly be a concern when the regions of interests are located in brain areas with low dopamine levels, but less so in the dopamine-rich striatum.…”
Section: Discussionmentioning
confidence: 99%
“…However, this would mostly be a concern for extended scanning times, as [ 18 F]DOPA behaves as an irreversibly bound tracer in the first 90 minutes after tracer injection, during which their uptake rates are tightly correlated (Becker et al, 2017;Doudet et al, 1999).…”
Section: Discussionmentioning
confidence: 99%
“…36 . However, this would mostly be a concern for extended scanning times, as [ 18 F]DOPA behaves as an irreversibly bound tracer in the first 90 min after tracer injection, during which their uptake rates are tightly correlated 34,35 . www.nature.com/scientificreports/ Another possibility is that the discrepancy between the original and the current study was introduced by group differences in sample characteristics.…”
Section: Discussionmentioning
confidence: 99%
“…[ 18 F]DOPA is a substrate for catechol-O-methyltransferase (COMT) in the periphery. Metabolites can cross the blood–brain-barrier and will distribute evenly throughout the brain, enhancing background noise relative to the use of [ 18 F]FMT, which is not a substrate for COMT 34 . However, this is mainly a concern when one is interested in brain areas with low dopamine levels, as opposed to the dopamine-rich striatum.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation