Comparative aspects of prostaglandin biosynthesis in animal tissues

Christ, E.J.; Dorp, D. A. van

doi:10.1016/0005-2760(72)90119-1

Cited by 246 publications

(42 citation statements)

References 22 publications

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“…There is general agreement that prostaglandins are not stored within cells (23)(24)(25)(26). Prostaglandin synthesis is rapid, apparently limited by substrate availability and hence turnover is extensive.…”

Section: Discussionmentioning

confidence: 99%

Renal prostaglandin synthesis in the spontaneously hypertensive rat.

Dünn¹

1976

J. Clin. Invest.

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A B S T R A C T Tlhe precise role of the kidney in spontaneous experimental hypertension is unknown. We have analyzed the rates of renal prostaglandin synthesis by utilizing a spontaneously hypertensive rat model. The synthetic rate of prostaglandin E2, prostaglandin F2a, and prostaglandin A2-like products was measured in vitro with renal microsomes. In the rabbit and rat there is a steep gradient of microsomal prostaglandin synthetase from papilla to cortex with highest activities in the papilla. Comparison of the activity of prostaglandin synthetase in medullary microsomes from normotensive and hypertensive rats showed accelerated synthesis in the spontaneously hiypertensive rat. These differences appeared after several months of age, were statistically significant from 3 mo of age and, on the average, represented at least a twofold increase of in vitro activity.All classes of prostaglandins were involved with increased synthesis of prostaglandin E2, prostaglandin F2, and prostaglandin A2-like material. These data reenforce and extend previous work showing alterations of granularity and presumably prostaglandin synthesis in renal medullary interstitial cells in various experimental hypertensions.We also measured renal tissue content of prostaglandin E and prostaglandin A-prostaglandin B by radioimmunoassay. Swift and careful handling of the tissue was necessary to avoid extensive postmortem synthesis of prostaglandins. In rapidly-frozen medullary tissue only prostaglandin E was detectable in concentrations ranging from 10 to 200 pg/mg tissue. No significant differences were found in the medullary content of Presented at the second U.S.-Japan seminar on the spontaneously hypertensive rat, April 1976, Newport Beach, Calif.

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Section: Discussionmentioning

confidence: 99%

Renal prostaglandin synthesis in the spontaneously hypertensive rat.

Dünn¹

1976

J. Clin. Invest.

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“…Evidence for prostanoid generation in non-insectan invertebrates One of the earliest descriptions of PG generation in invertebrates comes from the work of Christ and van Dorp (1972) who studied the ability of a wide range of invertebrates and vertebrates to synthesize PGs from radiolabelled eicosatrienoic acid. They found that conversion of this substrate to PGE 1 occurs in tissue homogenates from Mytilus (mussel), Homarus (lobster), Lumbricus (earthworm) and Cyanea (jellyfish) but not Anthoplexaura (coral), although the levels of conversion were reported to be rather small.…”

Section: Prostanoid Biosynthetic Pathways In Mammalsmentioning

confidence: 99%

Prostaglandins in non-insectan invertebrates: recent insights and unsolved problems

Rowley

Vogan

Taylor

et al. 2005

Journal of Experimental Biology

122

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Prostaglandins, together with thromboxanes (collectively termed prostanoids), are fatty acid derivatives of significant importance in many physiological processes. These compounds are formed following the action of cyclooxygenases (COX) and associated enzymes on C20 polyunsaturated fatty acid precursors released from phospholipids in membranes. Nearly all mammalian cell types have the biosynthetic machinery to produce at least one type of prostanoid. The same C20 fatty acid substrates can also be acted upon by lipoxygenases to produce mono-di-and trihydroxy derivatives such as leukotrienes, lipoxins and resolvins. The final route is the cytochrome P 450 pathway that can convert C20 fatty acids to hydroxylated derivatives.Collectively these compounds are called eicosanoids; the term derived from the Greek eikosi that refers to the C20 backbone in the parent fatty acid.Prostaglandins (PGs) were first discovered in the 1930s by von Euler and colleagues, who found a substance produced by the prostate gland that caused smooth muscle contraction. They christened the active substance 'prostaglandin', but it was over 30 years until the structure and mode of biosynthesis of these fatty acid derivatives became fully understood. PGs have many basic physiological functions where they act as 'local' hormones. For example, thromboxane (Tx) A 2 and prostacyclin (PGI 2 ) generated by platelets and endothelial cells, respectively, regulate the aggregatory behaviour of

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“…Prostaglandins -fatty-acid derivatives with highly potent, hormone-like activity -have been found in nanogram amounts in a great variety of animal tissues (Christ and van Dorp, 1972;Nomura and Ogata, 1976). In P. homomalla, however, PGA, (Fig.…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin A2: an agent of chemical defense in the Caribbean gorgonian Plexaura homomalla

Gerhart¹

1984

Mar. Ecol. Prog. Ser.

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Comparative aspects of prostaglandin biosynthesis in animal tissues

Cited by 246 publications

References 22 publications

Renal prostaglandin synthesis in the spontaneously hypertensive rat.

Renal prostaglandin synthesis in the spontaneously hypertensive rat.

Prostaglandins in non-insectan invertebrates: recent insights and unsolved problems

Prostaglandin A2: an agent of chemical defense in the Caribbean gorgonian Plexaura homomalla

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