Background: Soap is a solution used to lessen the number of living microorganisms on the surface of the skin, clothes, toilet and materials. It is a cleaning agent made by the chemical action of alkali on fats or fatty acids to yield the sodium or potassium salts of these acids. Objective : This study was carried out to assess antibacterial activity of common soaps used in Rwanda. Materials and methods: This was a cross-sectional study conducted in Susa Village, Musanze District, Rwanda. Skin, clothe, toilets and household used materials were taken as sample sites. Swabs were collected and taken in INES Ruhengeri microbiology laboratory to isolate and identify bacteria, and perform antimicrobial activity of soaps. Results: The most isolated bacteria were Citrobacter spp . (40%), P. aeruginosa and Enterobacter spp . (13.5%), S. aureus and E. coli (10.8%), Proteus spp . and Klebsiella spp . were isolated at 5.4%. Toilet gel and hand washing soap had the highest antibacterial compared to other soaps. Toilet gel antibacterial activity observed as indicated: E. coli (18mm), Enterobacter spp .(15mm) and S. aureus at 14mm, while for hand washing soap were seen as follows E.coli (24mm), followed by proteus (15mm), Klebsiella (13mm) and S .aureus (14mm) however Enterobacter and Citrobacter were resistant to hand washing soap. Duru soap showed the property to inhibit growth of S.aureus. but its antibacterial property was not effective to other bacteria . Clear and Tembo were not effective prevent the growth of bacteria. Conclusion: Hand washing soap, toilet gel could be used as antimicrobial agents. Clear, Tembo can be used to remove duties and oil on skin, clothes and materials.duru soap can be used as beauty soap.