Comparative Antidiabetic Potentials of Leaf Extracts of Salacia lehmbachii, Tetracarpidium conophorum, Artocarpus heterophyllus and Glibenclamide in Alloxan Induced Diabetic Rats

Abstract

Diabetes mellitus is a global public health disorder that threatens the economies of all nations, particularly developing countries. In this study the comparative effects of the antidiabetic potentials of Glibenclamide and three well known plants used by our locals in the management and prevention of diabetes was elucidated. DM was induced by intraperitoneal injection of alloxan at a dose of 100 Mg/Kg bodyweight. The rats were randomly divided into six groups (n=5). Group 1 is the normal control, fed with normal saline orally daily for 3 weeks. Group 2 is diabetic control given normal saline orally for 3 weeks. Group 3 is diabetic rats treated with leaf extracts of T. conophorum at concentrations of 50 mg/kg body weight orally for 3 weeks. Group 4 is diabetic rats Original Research Article