Comparative antibacterial study of black cumin oil of Saudi and Syrian origin seeds with the commercial product

Ahmad, Makhmur; Rashid, Mohammad A.; Ganaie, MajidA; Khan, Shamshir; Akhtar, Naseem; Shams, Saiba; Bilal, OmerS Hamid; Bisht, Dheeraj

doi:10.4103/jrptps.jrptps_118_20

Cited by 4 publications

(4 citation statements)

References 20 publications

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“… 127 , 128 Streptococcus mutans MIC: 2048 mg/mL MBC: 2048 mg/mL Enterococcus faecalis MIC: 2048 mg/mL MBEC: 2048 mg/mL 5 Saudi Arabia and Syria Oil of Nigella sativa Linn. 129 , 130 Staphylococcus aureus ATCC 29213 Zona hambat 24 dan 15 mm 6 Saudi Arabia Water extract 131 Staphylococcus aureus MIC: 6.5 mg/mL Enterococcus faecalis MIC: 6.5 mg/mL 7 India Methanol extract 132 Streptococcus mutans (MTCC 497) MIC: 0.2 mg/mL Water extract 132 Streptococcus mutans (MTCC 497) MIC: 0.3 mg/mL 8 Sigma-Aldrich Thymoquinone 133 Streptococcus mutans MIC: 8–16 mg/mL …”

Section: Biofilm Forming Gram-positive and Gram-negative Bacteriamentioning

confidence: 99%

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Phytochemical Analysis and Anti-Biofilm Potential That Cause Dental Caries from Black Cumin Seeds (Nigella sativa Linn.)

Kurnia,

Padilah,

Apriyanti

et al. 2024

DDDT

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The oral cavity is an excellent place for various microorganisms to grow. Spectrococcus mutans and Spectrococcus sanguinis are Gram-negative bacteria found in the oral cavity as pioneer biofilm formers on the tooth surface that cause caries. Caries treatment has been done with antibiotics and therapeutics, but the resistance level of S. mutans and S. sanguinis bacteria necessitates the exploration of new drug compounds. Black cumin (Nigella sativa Linn.) is known to contain secondary metabolites that have antioxidant, antibacterial, anti-biofilm, anti-inflammatory and antifungal activities. The purpose of this review article is to present data on the potential of Nigella sativa Linn seeds as anti-biofilm. This article will discuss biofilm-forming bacteria, the resistance mechanism of antibiotics, the bioactivity of N. sativa extracts and seed isolates together with the Structure Activity Relationship (SAR) review of N. sativa compound isolates. We collected data from reliable references that will illustrate the potential of N. sativa seeds as anti-biofilm drug.

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Section: Biofilm Forming Gram-positive and Gram-negative Bacteriamentioning

confidence: 99%

“…Anti-Biofilm of N. Sativa Seed Nigella sativa Linn 129,130. Staphylococcus aureus ATCC 29213 Zona hambat 24 dan 15 mm…”

mentioning

confidence: 99%

Phytochemical Analysis and Anti-Biofilm Potential That Cause Dental Caries from Black Cumin Seeds (Nigella sativa Linn.)

Kurnia,

Padilah,

Apriyanti

et al. 2024

DDDT

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“…Dimethyl sulfoxide (DMSO, 0.1% v/v in PBS) was used to prepare the samples. [ 15 , 16 ] Details of antibacterial activity of seed extract and silver nanoparticle is available in supplementary text .…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

“…The absorbance of the resultant solution at 517 nm was determined using UV-Vis spectrophotometry. [ 15 , 16 ] Details of radical scavenging activity and cumin seeds’ phytochemical analysis are available in supplementary text .…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

Silver Nanoparticles from Saudi and Syrian Black Cumin Seed Extracts: Green Synthesis, ADME, Toxicity, Comparative Research, and Biological Appraisal

Rashid,

Athar,

Abdelmageed

et al. 2023

Journal of Pharmacy and Bioallied Sciences

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Objective: The current study’s objective is to highlight the value of using plant resources to identify key bioactive molecules and implement green chemistry in research and development to meet market demand. Materials and Methods: The black cumin seeds (Saudi and Syria originated) were utilized to make silver nanoparticles (Ag-NPs), which were subsequently confirmed using a UV spectrophotometer and color analysis of reaction mixtures. The antibacterial activity of Ag-NPs was tested against E. coli, K. pneumoniae, and S. aureus, and antioxidant activity was measured using the DPPH assay. Swiss-ADME, pkCSM, and ProTox-II were also used to assess the pharmacokinetics, oral bioavailability, toxicity, and safety endpoints of molecules. Result: The antibacterial effect of Ag-NPs from Saudi-origin black cumin seeds was observed higher. In comparison to the standard, the Saudi and Syrian Ag-NPs combined displayed synergistic antibacterial effects and were found to be more susceptible to S. aureus. In comparison to the reference, the antioxidant activity of Ag-NPs indicated 60–85% radical scavenging. All molecules passed the Lipinski rule, the filter (Veber, Egan, and Muegge), PAINS, and the Brenk structural alert (zero violations), and the synthetic score was also found to be in the easy limit (1 to 2). The compounds were found to be non-substrate for p-glycoprotein, high GIA% (>90%), non-inhibitor for CYP3A4, CYP2C19, CYP2C9, CYP2D6 (except 5 and 10), Log Po/w (1.71 to 3.26), TPSA 150 2 and MR 155. The compounds likewise had high Caco2 values (log Papp >0.9) with the exception of 4 and 9 (log Papp 0.9), were non-inhibitors of P-gp-I and II and hERG I and II, and showed no AMES toxicity. Except for molecule 11, no organ damage (hepatotoxicity) or endpoint toxicity (mutagenicity, immunotoxicity, carcinogenicity, and cytotoxicity) was identified in ProTox-II. Conclusion: The current study sheds new light on the significance of bioactive molecules found in black cumin seeds, with molecules 3 and 6 identified as potential leads (highest GIA%, no AMES toxicity, oral rat acute and chronic toxicity, lack of renal OCT2 substrate, high total clearance, and lack of organ toxicity) for further research for a variety of medical applications.

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Structural characterization and oxidative stability of black cumin oil oleogels prepared with natural waxes

Orhan

Eroğlu

2022

Food Processing Preservation

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In this study, black cumin oil (BCO) oleogel was produced using natural waxes (beeswax: BW, sunflower wax: SFW, and carnauba wax: CW) to offer a healthy alternative to shortening. Oiling-off was observed only in the BW oleogel (3.88 ± 0.02%).The CW oleogel had the lowest E a (354.82 kJ/mol), indicating greater resistance to thermal degradation. The highest G′ and G″ were observed in the CW oleogel, while the lowest was observed in the BW oleogel. All oleogel samples displayed weak gel properties (tan δ > 0.1), but the lowest tan δ value belonged to the CW oleogel (0.12).After 4 weeks of storage, the peroxide values of the oleogels were lower than those of bulk oil (p < .05). Finally, the oxidation results showed that the BCO structuring by the waxes effectively protected it from oxidation over eight weeks of storage. Novelty impact statement:The most important innovation of the present study was to investigate the effect of BCO oleogelation on the stability of thymoquinone, the main phenolic compound of BCO. The BCO oleogels had higher thymoquinone content during the first half of the storage period compared with bulk BCO, showing that the oleogel network provides a protective effect against oxidation and thermal degradation.

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Comparative antibacterial study of black cumin oil of Saudi and Syrian origin seeds with the commercial product

Cited by 4 publications

References 20 publications

Phytochemical Analysis and Anti-Biofilm Potential That Cause Dental Caries from Black Cumin Seeds (Nigella sativa Linn.)

Phytochemical Analysis and Anti-Biofilm Potential That Cause Dental Caries from Black Cumin Seeds (Nigella sativa Linn.)

Silver Nanoparticles from Saudi and Syrian Black Cumin Seed Extracts: Green Synthesis, ADME, Toxicity, Comparative Research, and Biological Appraisal

Structural characterization and oxidative stability of black cumin oil oleogels prepared with natural waxes

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