Comparative animal study of three ligament prostheses for the replacement of the anterior cruciate and medial collateral ligament

Dürselen, Lutz; Claes, Lutz; Ignatius, Anita; Rübenacker, S.

doi:10.1016/0142-9612(96)84671-0

Cited by 47 publications

(26 citation statements)

References 16 publications

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“…Polyester and polytetrafluoroethylene (Goretex) have been used for cruciate ligament prostheses, but their clinical performance was not good enough to become currently used by orthopaedic surgeons (Dürselen et al 1996).…”

Section: Polymersmentioning

confidence: 99%

Biomaterials in orthopaedics

Navarro

Michiardi

Castaño

et al. 2008

J. R. Soc. Interface.

1,263

730

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At present, strong requirements in orthopaedics are still to be met, both in bone and joint substitution and in the repair and regeneration of bone defects. In this framework, tremendous advances in the biomaterials field have been made in the last 50 years where materials intended for biomedical purposes have evolved through three different generations, namely first generation (bioinert materials), second generation (bioactive and biodegradable materials) and third generation (materials designed to stimulate specific responses at the molecular level). In this review, the evolution of different metals, ceramics and polymers most commonly used in orthopaedic applications is discussed, as well as the different approaches used to fulfil the challenges faced by this medical field.

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Section: Polymersmentioning

confidence: 99%

Biomaterials in orthopaedics

Navarro

Michiardi

Castaño

et al. 2008

J. R. Soc. Interface.

1,263

730

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“…The sheep and goat have commonly been chosen as animal models for the knee [30][31][32][33] because of anatomical [34][35][36][37] and mechanical [38][39][40][41] similarities to human ACLs. These sheep were obtained from the Michigan Livestock Exchange, various farms in the area or intra-university transfer.…”

Section: Animal Model and Animal Carementioning

confidence: 99%

Three-Dimensional Engineered Bone–Ligament–Bone Constructs for Anterior Cruciate Ligament Replacement

Smietana

Kostrominova

et al. 2012

Tissue Engineering Part A

114

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The anterior cruciate ligament (ACL), a major stabilizer of the knee, is commonly injured. Because of its intrinsic poor healing ability, a torn ACL is usually reconstructed by a graft. We developed a multi-phasic, or boneligament-bone, tissue-engineered construct for ACL grafts using bone marrow stromal cells and sheep as a model system. After 6 months in vivo, the constructs increased in cross section and exhibited a well-organized microstructure, native bone integration, a functional enthesis, vascularization, innervation, increased collagen content, and structural alignment. The constructs increased in stiffness to 52% of the tangent modulus and 95% of the geometric stiffness of native ACL. The viscoelastic response of the explants was virtually indistinguishable from that of adult ACL. These results suggest that our constructs after implantation can obtain physiologically relevant structural and functional characteristics comparable to those of adult ACL. They present a viable option for ACL replacement.

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“…Por causa do amplo tamanho, a articulação do joelho de ovinos facilita os estudos relacionados a transplante de menisco, ruptura de ligamento cruzado, transplante de cartilagem e transplante articular (Swindle & Adams 1988, Jackson et al 1992, Dürselen et al 1996, Szomor et al 2000, Kelly et al 2006.…”

Section: Introductionunclassified

“…Visto o número limitado de trabalhos experimentais que utilizaram o exame artroscópico em ovinos (Dürselen et al 1996, Lu et al 2000, Szomor et al 2000, Lu et al 2006) e a importância desses animais como modelo experimental, o presente trabalho teve por objetivo avaliar a articulação do joelho de ovinos hígidos em diferentes idades, com o intuito de determinar, de acordo com os portais estabelecidos, a capacidade de observação das estruturas.…”

Section: Introductionunclassified

Artroscopia do joelho de ovinos

et al. 2008

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O trabalho teve por objetivo avaliar artroscopicamente a articulação do joelho de ovinos hígidos em diferentes idades, com o intuito de determinar, de acordo com os portais estabelecidos, a capacidade de observação das estruturas. Utilizaram-se 18 animais da raça Santa Inês, divididos em três grupos experimentais eqüitativos, conforme a idade cronológica, sendo: Grupo I, 6-8 meses (peso médio de 25 kg); Grupo II, 2 anos (peso médio de 50 kg); e Grupo III, 3,5-5 anos (peso médio de 55 kg). Foram estabelecidos três portais: (1) portal artroscópico primário, craniolateral; (2) portal para fluxo de drenagem; e (3) portal instrumental, craniomedial. Identificaram-se com facilidade a patela, sulco e bordas trocleares, côndilos medial e lateral do fêmur, e tendão do músculo extensor longo dos dedos. Após a remoção da maior parte do coxim gorduroso infrapatelar com emprego do "shaver" foram visibilizados, ainda com dificuldade, os ligamentos cruzados e os meniscos. Para a identificação dos primeiros foram necessárias movimentos de flexão e extensão e para os meniscos manobras de varo e valgo. O grau de dificuldade foi inversamente proporcional ao tamanho da articulação. Sendo assim, foi possível concluir que os portais artroscópicos utilizados possibilitaram a identificação das principais estruturas articulares, independente da idade, e o método em si teve por vantagem a rápida recuperação pós-operatória dos animais.

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Comparative animal study of three ligament prostheses for the replacement of the anterior cruciate and medial collateral ligament

Cited by 47 publications

References 16 publications

Biomaterials in orthopaedics

Biomaterials in orthopaedics

Three-Dimensional Engineered Bone–Ligament–Bone Constructs for Anterior Cruciate Ligament Replacement

Artroscopia do joelho de ovinos

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