Comparative anatomical study of the tegmentomammillary projections in some mammals: A horseradish peroxidase study

Hayakawa, Tetsu; Zyo, Katuya

doi:10.1016/0006-8993(84)90844-8

Cited by 52 publications

(30 citation statements)

References 41 publications

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“…It is well known that the ventral tegmental nucleus of Gudden and the pars compacta of the nucleus centralis superior project to the medial mammillary nucleus (Hayakawa and Zyo 1984;Shibata 1987;Allen and Hopkins 1989). Shibata (1987) has shown a few labeled collateral fibers in the SUM after WGA-HRP injection into the ventral tegmental nucleus.…”

Section: Discussionmentioning

confidence: 99%

Neuroanatomical study of afferent projections to the supramammillary nucleus of the rat

1993

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We examined the regions projecting to the supramammillary nucleus of the rat with retrograde transport of WGA-HRP and WGA, and anterograde transport of Phaseolus vulgaris leucoagglutinin. The supramammillary nucleus receives major descending afferents from the infralimbic cortex, the dorsal peduncular cortex, the nucleus of the diagonal band of Broca, the medial and lateral preoptic nuclei, bilaterally. The major ascending afferents come from the pars compacta of the nucleus centralis superior, the ventral tegmental nucleus, and the laterodorsal tegmental nucleus. The supramammillary nucleus also receives a few (but distinct) fibers from the anterior and lateral hypothalamic nuclei, the ventral premammillary nucleus, the interpeduncular nucleus, the cuneiform nucleus, the dorsal raphe nucleus, the incertus nucleus, and the C3 region including the prepositus hypoglossi nucleus. All descending fibers run through the medial forebrain bundle. Almost all ascending fibers from the pars compacta of the nucleus centralis superior and the laterodorsal tegmental nucleus run through the mammillary peduncle, and terminate throughout the supramammillary nucleus. A few fibers from the laterodorsal tegmental nucleus and the C3 region run through the fasciculus longitudinalis dorsalis and terminate in the dorsal part of the supramammillary nucleus including the supramammillary decussation.

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Section: Discussionmentioning

confidence: 99%

Neuroanatomical study of afferent projections to the supramammillary nucleus of the rat

1993

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“…In Nissl-stained coronal sections the central division is expressed as a small, darkly-staining dense grouping of larger neurons and the peri-central division shows up as a larger, more diffuse group of smaller neurons (Figure 3A–B). Previous anatomical work has shown that the central division provides the strongest connectivity with the HD cell circuit via massive projections to the lateral mammillary nuclei (Hayakawa & Zyo, 1984). Thus, although we aimed to produce complete lesions of both DTN subregions, the central division was the primary target in the present study.…”

Section: General Methodsmentioning

confidence: 99%

Lesions of the dorsal tegmental nuclei disrupt control of navigation by distal landmarks in cued, directional, and place variants of the Morris water task.

Clark¹,

Rice²,

Akers³

et al. 2013

Behavioral Neuroscience

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Navigation depends on a network of neural systems that accurately monitor an animal’s directional heading and location in an environment. Within this navigation system are head direction (HD) cells, which discharge as a function of an animal’s directional heading, providing an animal with a neural compass to guide ongoing spatial behavior. Experiments were designed to test this hypothesis by damaging the dorsal tegmental nucleus (DTN), a mid-brain structure that plays a critical role in the generation of the rodent HD cell signal, and evaluating landmark based navigation using variants of the Morris water task. In Experiments 1 and 2, shams and DTN lesioned rats were trained to navigate toward a cued platform in the presence of a constellation of distal landmarks located outside the pool. After reaching a training criteria, rats were tested in three probe trials in which 1) the cued platform was completely removed from the pool, 2) the pool was repositioned and the cued platform remained in the same absolute location with respect to distal landmarks, or 3) the pool was repositioned and the cued platform remained in the same relative location in the pool. In general, DTN-lesioned rats required more training trials to reach performance criterion, were less accurate to navigate to the platform position when it was removed, and navigated directly to the cued platform regardless of its position in the pool, indicating a general absence of control over navigation by distal landmarks. In Experiment 3, DTN and control rats were trained in directional and place navigation variants of the water task where the pool was repositioned for each training trial and a hidden platform was placed either in the same relative location (direction) in the pool or in the same absolute location (place) in the distal room reference frame. DTN-lesioned rats were initially impaired in the direction task, but ultimately performed as well as controls. In the place task, DTN-lesioned rats were severely impaired and displayed little evidence of improvement over the course of training. Together, these results support the conclusion that the DTN is required for accurate landmark navigation.

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“…~ ' Anterograde and retrograde tracing studies have shown that the TDV sends many fibers to the LM (Briggs and Kaelber 1971;Hayakawa and Zyo 1984;Shibata 1987), and a few fibers to the lateral hypothalamic nucleus (Berk and Finkelstein 1981; 1985) and the contralateral dorsal tegmental nucleus (Liu et al 1984). The TDV receives fibers from the LM, the lateral habenular nucleus, the interpeduncular nucleus, the prepositus hypoglossi nucleus, and the supragenual nucleus (Herkenham and Nauta 1979;Hayakawa et al 1981;Liu et al 1984;Shibata and Suzuki 1984;Hayakawa and Zyo 1985).…”

Section: Discussionmentioning

confidence: 99%

“…The lateral mammillary nucleus (LM) receives many fibers from the subicular complex (Meibach and Siegel Offprint requests to: T. Hayakawa 1977; Swanson and Cowan 1977) and the pars ventralis of the dorsal tegmental nucleus of Gudden (TDV) (Morest 1961;Briggs and Kaelber 1971; 1973; Hayakawa and Zyo 1984), while sending collateral fibers to the pars dorsalis and ventralis of the dorsal tegmental nucleus of Gudden, the medial pontine nucleus, the nucleus reticularis tegmenti pontis, and the bilateral anterodorsal thalamic nuclei (Niimi et al 1972;Cruce 1977;Hayakawa and Zyo 1982, 1989Veazey etal. 1982b).…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural study of ascending projections to the lateral mammillary nucleus of the rat

Hayakawa

Zyo

1992

Anat Embryol

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We examined the synaptic organization of ascending projections from the pars ventralis of the dorsal tegmental nucleus of Gudden (TDV) and the laterodorsal tegmental nucleus to the lateral mammillary nucleus (LM). The LM neuropil consists of terminals containing pleomorphic synaptic vesicles and forming symmetric synaptic contact, and terminals containing round synaptic vesicles and forming asymmetric synaptic contact. They make up 63% and 37%, respectively, of all axodendritic terminals. All axosomatic terminals contain pleomorphic vesicles and make symmetric contact. Following injection of WGA-HRP into the TDV, many anterogradely labeled terminals and retrogradely labeled cells are found in the LM. Labeled terminals contact mainly proximal (more than 2 microns diameter) and intermediate (1-2 microns diameter) dendrites. Serial ultrathin sections of the LM show that 55% of axosomatic terminals are labeled anterogradely. Following injection of WGA-HRP into the laterodorsal tegmental nucleus, many anterogradely labeled terminals are found in the LM, but no retrogradely labeled cells are present. Labeled terminals contact mainly distal (less than 1 micron diameter) and intermediate dendrites as well as somata. In the LM neurons, 46% of axosomatic terminals are labeled anterogradely. All labeled terminals from these nuclei contain pleomorphic vesicles and make symmetric synaptic contact. These results indicate that almost all axosomatic terminals come from the TDV and the laterodorsal tegmental nucleus, which send inhibitory inputs to the lateral mammillary nucleus.

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Comparative anatomical study of the tegmentomammillary projections in some mammals: A horseradish peroxidase study

Cited by 52 publications

References 41 publications

Neuroanatomical study of afferent projections to the supramammillary nucleus of the rat

Neuroanatomical study of afferent projections to the supramammillary nucleus of the rat

Lesions of the dorsal tegmental nuclei disrupt control of navigation by distal landmarks in cued, directional, and place variants of the Morris water task.

Ultrastructural study of ascending projections to the lateral mammillary nucleus of the rat

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