Comparative analysis on the effect of Lycopersicon esculentum (tomato) in reducing cadmium, mercury and lead accumulation in liver

Nwokocha, Chukwuemeka R.; Nwokocha, Magdalene; Aneto, Imaria; Obi, Joshua; Udekweleze, Damian C.; Olatunde, Bukola; Owu, Daniel U.; Iwuala, M. O. E.

doi:10.1016/j.fct.2012.03.079

Cited by 47 publications

(29 citation statements)

References 36 publications

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“…Moreover, tomato has been reported to produce metal chelating proteins and phytochelatins when exposed to heavy metal ions (Tito et al, 2011;Steffens et al, 1986). In fact, the oral administration of tomato significantly reduces the accumulation of heavy metals (Cd, Pb and Hg) in the liver of rats (Nwokocha et al, 2012). To develop new natural alternatives with biological activities and reduced secondary effects, we evaluate the chelating effect of Coriandrum sativum extract on Wistar rats administrated with lead acetate.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Chelating Effect of Methanolic Extract of Coriandrum Sativum and Its Fractions on Wistar Rats Poisoned With Lead Acetate

Téllez-López

Mora-Tovar

Ceniceros-Méndez

et al. 2017

Afr J Tradit Complement Altern Med

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Background: The rate of lead poisoning has decreased in recent years due to increased health control in industries that use this metal. However, it is still a public health problem worldwide. The use of various plants with chelating properties has been a topic of research today. In traditional medicine, it is said that Coriandrum sativum has chelating properties, but there is no scientific evidence to support this fact. The purpose of this research is to evaluate the chelating effect of methanol extract of coriander and its fractions on Wistar rats intoxicated with lead. Materials and Methods: In this research, male Wistar rats were poisoned with 50 mg/kg of lead acetate and treated with 50 mg/kg of methanol extract and its fractions. The extract and its fractions were administered to four treatment groups. Positive and negative controls were established. Hemoglobin, hematocrit and lead concentrations were analyzed; liver was evaluated histologically in control and treatment groups. Results: The methanol extract of coriander presented a LD 50 ˃1000 mg/dL. The group administered with the methanol extract showed significant difference in the levels of hemoglobin and hematocrit compared to the negative control group. Lead concentration in treatment groups showed a decrease compared to the positive control. Histological evaluation of tissue showed less damage in groups administered with methanolic extract and its fractions compared to the positive control which presented structural alterations. Conclusion: Coriander extracts protect liver and lower lead concentration in rats intoxicated with lead in contrast to the positive control group.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Chelating Effect of Methanolic Extract of Coriandrum Sativum and Its Fractions on Wistar Rats Poisoned With Lead Acetate

Téllez-López

Mora-Tovar

Ceniceros-Méndez

et al. 2017

Afr J Tradit Complement Altern Med

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“…[6] Reports on the increasing role and usefulness of medicinal plant products in maintenance and optimization of health have led to research on the efficacy of these medicinal plants/nutrient products’ effects on the amelioration of the metal-induced toxicity. [910111213] These plant products are reported to affect the bioavailability, transport, and toxico-dynamics of this metal in the tissues.…”

Section: Introductionmentioning

confidence: 99%

“…[1115] Garcinia kola characteristics to act as chelators of divalent metal,[91617] and Tomato's, ( Lycopersicon esculentum ) abilities to synthesize metal chelating proteins, metallothioneins, peptides, phytochelatins[121819] have all been reported and documented. These medicinal plant products are also reported for their prophylactic and curative uses, which is related to their antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

“…We have recently shown that G. kola ,[9] A. sativum ,[10] Z. officinale [11] and L. esculentum [12] reduced hepatotoxic effect of lead through a hepato-protective role. This study is to comparatively study the effects of these nutrients and medicinal plants on lead accumulation in the liver of rats following different treatment interventions.…”

Section: Introductionmentioning

confidence: 99%

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A comparative study of the effect of some nutritional medicinal plants effect on lead accumulation in the liver following different modes of administration

et al. 2014

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Context and Objectives:Lead (Pb) toxicity leads to cell damage in many organs of the body. Using different treatment interventions and modes of administration we comparatively examined the protective ability of some medicinal plants on liver Pb accumulation.Materials and Methods:Rats were fed on either 7% w/w Zingiber officinale, 7% w/w Allium sativum, 10% w/w Lycopersicon esculentum, 5%, w/w Garcinia kola (all in rat chow), while Pb (100 ppm) was given in drinking water. The additives were administered together with (mode 1), a week after exposure to (mode 2) or a week before metal exposure to (mode 3) the metal for a period of 6 weeks. The metal accumulations in the liver were determined using atomic absorption spectrometry and compared using analysis of variance.Results:Some additives significantly (P < 0.05) reduced, while others enhanced Pb accumulation. Mode 2 yielded the highest mean % protection and mode 3 the lowest, no significant interaction between modes of administration and time of measurement in their relationships to percentage protection, but there was statistically significant (P < 0.05) interaction between modes of administration and additive used in their relationships to percentage protection.Conclusion:Protective effects of medicinal plants are varied and depend on the nature of lead exposure.

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“…Recently, it was found that G. kola, A. sativum, Z. officinale and L. esculentum reduced hepatotoxic effect of lead [14][15][16][17]. We have found that honey has beneficial effects on renal function in normal volunteers [18].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity

Fihri¹,

Al-Waili²,

El-Haskoury³

et al. 2016

Cell Physiol Biochem

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Background/Aims: Natural honey has many biological activities including protective effect against toxic materials. The aim of this study was to evaluate the protective effect of carob honey against lead-induced hepato-renal toxicity and lead-induced anemia in rabbits. Methods: Twenty four male rabbits were allocated into four groups six rabbits each; group 1: control group, received distilled water (0.1 ml / kg.b.wt /daily); group 2: received oral lead acetate (2 g/kg.b.wt/daily); group 3: treated with oral honey (1g /kg.b.wt/daily) and oral lead (2 g/kg.b.wt/daily), and group 4: received oral honey (1 g/kg.b.wt/daily). Honey and lead were given daily during 24 days of experimentation. Laboratory tests and histopathological evaluations of kidneys were done. Results: Oral administration of lead induced hepatic and kidney injury and caused anemia during three weeks of the exposure. Treatment with honey prevented hepato-renal lead toxicity and ameliorated lead-induced anemia when honey was given to animals during lead exposure. Conclusion: It might be concluded that honey has a protective effect against lead-induced blood, hepatic and renal toxic effects.

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Comparative analysis on the effect of Lycopersicon esculentum (tomato) in reducing cadmium, mercury and lead accumulation in liver

Cited by 47 publications

References 36 publications

Evaluation of the Chelating Effect of Methanolic Extract of Coriandrum Sativum and Its Fractions on Wistar Rats Poisoned With Lead Acetate

Evaluation of the Chelating Effect of Methanolic Extract of Coriandrum Sativum and Its Fractions on Wistar Rats Poisoned With Lead Acetate

A comparative study of the effect of some nutritional medicinal plants effect on lead accumulation in the liver following different modes of administration

Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity

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