Comparative analysis of transforming growth factor-β isoforms 1–3 in human and rabbit dentine matrices

Cassidy, N.; Fahey, Mark; Prime, Stephen S.; Smith, Anthony J.

doi:10.1016/s0003-9969(96)00115-x

Cited by 176 publications

(143 citation statements)

References 15 publications

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“…Odontoblasts, in turn, then express TGF-␤, which acts in an autocrine manner to stimulate the secretion of predentin and dentin (Lesot et al, 2001). This proposal is consistent with observations showing the presence of TGF-␤ isoforms in dentin matrices (Cassidy et al, 1997) and both TGF-␤ isoforms and T␤R-I and T␤R-II in odontoblasts (Sloan et al, 1999(Sloan et al, , 2000. These findings suggest an active TGF-␤ signaling complex at the primary site of dental hard-tissue formation.…”

Section: (C) Tooth Morphogenesissupporting

confidence: 90%

TGF-β Signal Transduction in Oro-facial Health and Non-malignant Disease (Part I)

Prime

Pring

Davies

et al. 2004

Critical Reviews in Oral Biology & Medicine

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ABSTRACT:The transforming growth factor-beta (TGF-␤) family of cytokines consists of multi-functional polypeptides that regulate a variety of cell processes, including proliferation, differentiation, apoptosis, extracellular matrix elaboration, angiogenesis, and immune suppression, among others. In so doing, TGF-␤ plays a key role in the control of cell behavior in both health and disease. In this report, we review what is known about the mechanisms of activation of the peptide, together with details of TGF-␤ signal transduction pathways. This review summarizes the evidence implicating TGF-␤ in normal physiological processes of the craniofacial complex-such as palatogenesis, tooth formation, wound healing, and scarring-and then evaluates its role in non-malignant disease processes such as scleroderma, submucous fibrosis, periodontal disease, and lichen planus.

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Section: (C) Tooth Morphogenesissupporting

confidence: 90%

TGF-β Signal Transduction in Oro-facial Health and Non-malignant Disease (Part I)

Prime

Pring

Davies

et al. 2004

Critical Reviews in Oral Biology & Medicine

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“…First, several signaling molecules such as TGFβ, BMPs, and fibroblast growth factors (FGFs) are found in the dentin matrix (Cassidy et al 1997;Roberts-Clark and Smith 2000;Thomadakis et al 1999). Therefore, a variety of biological effects arising from the dentin matrix dissolution may exist in the pulpal healing process.…”

Section: Discussionmentioning

confidence: 99%

The Expression of GM-CSF and Osteopontin in Immunocompetent Cells Precedes the Odontoblast Differentiation Following Allogenic Tooth Transplantation in Mice

Saito

Nakatomi

Ida‐Yonemochi

et al. 2011

J Histochem Cytochem.

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Dental pulp elaborates both bone and dentin under pathological conditions such as tooth replantation/transplantation. This study aims to clarify the expression of granulocyte macrophage colony-stimulating factor (GM-CSF) and osteopontin (OPN) in the process of reparative dentin formation by allogenic tooth transplantation using in situ hybridization for OPN and immunohistochemistry for GM-CSF and OPN at both levels of light and electron microscopes. Following the extraction of the mouse molar, the roots and pulp floor were resected and immediately allografted into the sublingual region. On days 1 to 3, immunocompetent cells such as macrophages and dendritic cells expressed both GM-CSF and OPN, and some of them were arranged along the pulp-dentin border and extended their cellular processes into the dentinal tubules. On days 5 to 7, tubular dentin formation commenced next to the preexisting dentin at the pulp horn where nestin-positive odontoblast-like cells were arranged. Until day 14, bone-like tissue formation occurred in the pulp chamber, where OPN-positive osteoblasts surrounded the bone matrix. These results suggest that the secretion of GM-CSF and OPN by immunocompetent cells such as macrophages and dendritic cells plays a role in the maturation of dendritic cells and the differentiation of odontoblasts, respectively, in the regenerated pulp tissue following tooth transplantation.

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“…In addition to dentine matrix proteins the dentine contains a variety of growth factors such as bone borphogenetic protein (BMP), transforming growth factor p (TGF-p) (Cassidy et al 1997;Sloan et al 2000) and insulin-like growth factors (IGF) I and II (Finkelman et al 1990). These growth factors are incorporated into the matrix during synthesis and, as previously outlined, are also involved in the differentiation of odontoblasts when they may be associated with the basement membrane (Begue- ) and in stimulating matrix secretion (Begue-Kim et al 1992).…”

Section: Dentinementioning

confidence: 99%

Development of an Ex Vivo Coculture System to Model Pulpal Infection by Streptococcus anginosus Group Bacteria

Roberts¹,

Maillard²,

Waddington³

et al. 2013

Journal of Endodontics

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Comparative analysis of transforming growth factor-β isoforms 1–3 in human and rabbit dentine matrices

Cited by 176 publications

References 15 publications

TGF-β Signal Transduction in Oro-facial Health and Non-malignant Disease (Part I)

TGF-β Signal Transduction in Oro-facial Health and Non-malignant Disease (Part I)

The Expression of GM-CSF and Osteopontin in Immunocompetent Cells Precedes the Odontoblast Differentiation Following Allogenic Tooth Transplantation in Mice

Development of an Ex Vivo Coculture System to Model Pulpal Infection by Streptococcus anginosus Group Bacteria

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