Comparative Analysis of Therapeutic Effect of Plasmolifting on the Ankle and Appendicular Joints

Abstract

The case of joints of the upper and lower appendages is the matter for discussion of differences in mechanisms of therapeutic effect of the plasmolifting (PL). It involves 3–5 time injections of platelet mass extracted from autologous blood into injury area spaced a week apart. The ankle joint subjected to PL therapy, compared against knee, elbow and shoulder joints, shows an extremely low ability for restoration of its functionality. Therapeutic benefit is contributed by ability of biologically active substances (BAS) and cytokines released by platelets (Pl) for activation of metabolic processes within damaged tissues. In turn, it insures restoration of morphofunctional disorders of inflammatory genesis and reparative capabilities. Successive application of PL is directly dependent on the tissues that make up a certain joint. The positive effect of the introduction of Pl auto-suspension is determined by the presence of cytokine donor cells, especially platelet activation factor (PAF). Their sufficient amount triggers Pl granulation. An extensive capillary network results with a saturated blood supply and ensures access of granulocyte cells to the sanitized tissue. Besides, basophils and mast cells of connective tissue together with the endothelium of the above capillaries are also PAF sources. All of the above provides a positive therapeutic effect of the PL method on the knee, elbow and shoulder joints unlike the absence of its practical therapeutic effect on the ankle joint and Achilles tendon.