Comparative analysis of the serum microbiome of HIV infected individuals

Ali, Zain; Shahzadi, Iram; Majeed, Aqsa; Malik, Hafiz Muhammad Talha; Waseem, Shahid; Ahmed, Ibrar; Anis, Riffat Aysha; Saeed, Sadia; Anees, Mariam

doi:10.1016/j.ygeno.2021.10.005

Cited by 8 publications

(5 citation statements)

References 31 publications

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“…However, emerging evidence has described the presence of microbial genomes circulating in human blood in both healthy and pathological conditions. [42][43][44][45] Recent research on the origin of the microbiome in blood suggests that it is partially derived from the gut through bacterial translocation, possibly via disruption of intestinal mucosa integrity leading to gut leaks. 46 As EVs can cross the bloodbrain barrier, circulating bacterial EVs may act as a key mediator of the microbiota-gut-brain axis and microbiota-brain immune interactions 16,17 ; EVs released by the microbiota of the gut and other regions may interact with the immune system or travel to the brain and interact with the nervous systems, thereby affecting brain function and neuropsychiatric disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, human blood has been thought to be normally sterile, except in certain medical conditions, such as septic shock. However, emerging evidence has described the presence of microbial genomes circulating in human blood in both healthy and pathological conditions 42–45 . Recent research on the origin of the microbiome in blood suggests that it is partially derived from the gut through bacterial translocation, possibly via disruption of intestinal mucosa integrity leading to gut leaks 46 .…”

Section: Discussionmentioning

confidence: 99%

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Microbiome analysis of circulating bacterial extracellular vesicles in obsessive‐compulsive disorder

Kang,

Seo,

Park

et al. 2023

Psychiatry Clin Neurosci

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AimThe present study examined the microbiome abundance and composition of drug‐naive or drug‐free patients with obsessive‐compulsive disorder (OCD) compared with healthy controls. In addition, in the OCD group, the microbiome composition was compared between early‐onset and late‐onset OCD.MethodsSerum samples were collected from 89 patients with OCD and 107 age‐ and sex‐matched healthy controls. Bacterial DNA was isolated from bacteria‐derived extracellular vesicles in serum and then amplified and quantified using primers specific to the V3‐V4 hypervariable region of the 16S ribosomal RNA gene. The 16S ribosomal DNA gene amplicon sequencing was performed.ResultsThe pooled estimate showed that α‐diversity was significantly reduced in patients with OCD compared with that in healthy controls (PShannon = 0.00015). In addition, a statistically significant difference was observed in β‐diversity between patients with OCD and healthy controls at the order (P = 0.012), family (P = 0.003), genus (P < 0.001), and species (P = 0.005) levels. In the microbiome composition, Pseudomonas, Caulobacteraceae (f), Streptococcus, Novosphingobium, and Enhydrobacter at the genus level were significantly less prevalent in patients with OCD than in controls. In addition, among patients with OCD, the microbial composition in the early‐onset versus late‐onset types was significantly different with respect to the genera Corynebacterium and Pelomonas.ConclusionThe present study showed an aberrant microbiome in patients with OCD, suggesting a role of the microbiota‐brain interaction in the pathophysiology of OCD. Further longitudinal studies with larger sample sizes adjusting for various confounders are warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Microbiome analysis of circulating bacterial extracellular vesicles in obsessive‐compulsive disorder

Kang,

Seo,

Park

et al. 2023

Psychiatry Clin Neurosci

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“…Changes in gut microbiome populations contribute to sustaining chronic inflammation [82] and bacterial populations with inflammatory potential detected in stool samples increase to a greater extend in PLWH with age [83]. Furthermore, reduced diversity is also observed in the serum microbiome with treated HIV [84]. However, only minimal changes in microbiome diversity of the gastrointestinal tract are observed after early HIV seroconversion [85 ▪▪ ].…”

Section: Biological Aging Hallmarksmentioning

confidence: 99%

Decrypting biological hallmarks of aging in people with HIV

Premeaux

Ndhlovu

2023

Current Opinion in HIV and AIDS

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Purpose of review HIV infection adds further complexity to the heterogenous process of aging. In this focused review, we examine and discuss recent advances to better elucidate mechanisms of biological aging perturbed and accelerated in the context of HIV, particularly among those with viral suppression through the benefits of antiretroviral therapy (ART). New hypotheses from these studies are poised to provide an improved understanding of multifaceted pathways that converge and likely form the basis for effective interventions toward successful aging. Recent findings Evidence to date suggests multiple mechanisms of biological aging impact people living with HIV (PLWH). Recent literature delves and expands on how epigenetic alterations, telomere attrition, mitochondrial perturbations, and intercellular communications may underpin accelerated or accentuated aging phenotypes and the disproportionate prevalence of age-related complications among PLWH. Although most hallmarks of aging are likely exacerbated in the setting of HIV, ongoing research efforts are providing new insight on the collective impact these conserved pathways may have in the aging disease processes. Summary New knowledge on underlying molecular disease mechanisms impacting people aging with HIV are reviewed. Also examined are studies that may facilitate the development and implementation of effective therapeutics and guidance on improving geriatric HIV clinical care.

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“…With the development of modern and advanced tools, human microbiome research has progressed exponentially (NIH Human Microbiome Portfolio Analysis Team, 2019). In relation to the alteration of microbiome under HIV-infected and/or AIDS-affected situations, several studies have been reported on gut (Dillon et al, 2016;Monaco et al, 2016), oral (Zhang et al, 2015;Ali et al, 2021;Li et al, 2021a), serum (Ali et al, 2021), and lung microbiome (Zhu et al, 2022). However, taking the topic of skin microbiome into account, to the best of our knowledge, no study has been reported on the skin microbiome in AIDS patients nor in HIV infected individuals without AIDS and how this may be associated to the presence of dermatological infections.…”

Section: Introductionmentioning

confidence: 97%

Skin microbiome profile in people living with HIV/AIDS in Cameroon

Ogai,

Nana,

Lloyd

et al. 2023

Front. Cell. Infect. Microbiol.

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The presence of pathogens and the state of diseases, particularly skin diseases, may alter the composition of human skin microbiome. HIV infection has been reported to impair gut microbiome that leads to severe consequences. However, with cutaneous manifestations, that can be life-threatening, due to the opportunistic pathogens, little is known whether HIV infection might influence the skin microbiome and affect the skin homeostasis. This study catalogued the profile of skin microbiome of healthy Cameroonians, at three different skin sites, and compared them to the HIV-infected individuals. Taking advantage on the use of molecular assay coupled with next-generation sequencing, this study revealed that alpha-diversity of the skin microbiome was higher and beta-diversity was altered significantly in the HIV-infected Cameroonians than in the healthy ones. The relative abundance of skin microbes such as Micrococcus and Kocuria species was higher and Cutibacterium species was significantly lower in HIV-infected people, indicating an early change in the human skin microbiome in response to the HIV infection. This phenotypical shift was not related to the number of CD4 T cell count thus the cause remains to be identified. Overall, these data may offer an important lead on the role of skin microbiome in the determination of cutaneous disease state and the discovery of safe pharmacological preparations to treat microbial-related skin disorders.

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Comparative analysis of the serum microbiome of HIV infected individuals

Cited by 8 publications

References 31 publications

Microbiome analysis of circulating bacterial extracellular vesicles in obsessive‐compulsive disorder

Microbiome analysis of circulating bacterial extracellular vesicles in obsessive‐compulsive disorder

Decrypting biological hallmarks of aging in people with HIV

Skin microbiome profile in people living with HIV/AIDS in Cameroon

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