Comparative analysis of the risk of osteoporotic fractures with proton pump inhibitor use and histamine-2 receptor antagonist therapy in elderly women: A nationwide population-based nested case-control study

Park, Joo-Hyun; Song, Yun-Mi; Jung, Jin‐Hyung; Han, Kyungdo

doi:10.1016/j.bone.2020.115306

Cited by 12 publications

(10 citation statements)

References 52 publications

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“…A positive, albeit modest, association between PPIs and OP was reported in animal [ 262 , 263 , 264 ] and numerous of human studies. Many studies and meta-analyses suggested that acid inhibitors, especially the PPIs, moderately increase risk of fractures, particularly in older adults (who are already at higher fracture risk); the risk increases with longer durations of PPI use, often only in the presence of at least one other RF for OP such as older age, female gender and a higher comorbidity score [ 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 278 , 279 , 280 , 281 , 282 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 290 ]. Moreover, use of PPIs may also increase risk of falls [ 291 , 292 , 293 ].…”

Section: Hpi-induced Upper Gut Diseases and Osteoporotic Fracturesmentioning

confidence: 99%

“…Regarding the effects of H2RA, most investigators observed little influence on BMD even in long-term (>5 years) users [ 268 , 269 , 279 , 290 , 301 , 314 ], but some researchers found lower BMD (if calcium intake was reduced) [ 316 ] and an increased hip fracture risk with high doses [ 276 ].…”

Section: Hpi-induced Upper Gut Diseases and Osteoporotic Fracturesmentioning

confidence: 99%

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Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Fisher

Smith

2020

JCM

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Osteoporosis (OP) and osteoporotic fractures (OFs) are common multifactorial and heterogenic disorders of increasing incidence. Helicobacter pylori (H.p.) colonizes the stomach approximately in half of the world’s population, causes gastroduodenal diseases and is prevalent in numerous extra-digestive diseases known to be associated with OP/OF. The studies regarding relationship between H.p. infection (HPI) and OP/OFs are inconsistent. The current review summarizes the relevant literature on the potential role of HPI in OP, falls and OFs and highlights the reasons for controversies in the publications. In the first section, after a brief overview of HPI biological features, we analyze the studies evaluating the association of HPI and bone status. The second part includes data on the prevalence of OP/OFs in HPI-induced gastroduodenal diseases (peptic ulcer, chronic/atrophic gastritis and cancer) and the effects of acid-suppressive drugs. In the next section, we discuss the possible contribution of HPI-associated extra-digestive diseases and medications to OP/OF, focusing on conditions affecting both bone homeostasis and predisposing to falls. In the last section, we describe clinical implications of accumulated data on HPI as a co-factor of OP/OF and present a feasible five-step algorithm for OP/OF risk assessment and management in regard to HPI, emphasizing the importance of an integrative (but differentiated) holistic approach. Increased awareness about the consequences of HPI linked to OP/OF can aid early detection and management. Further research on the HPI–OP/OF relationship is needed to close current knowledge gaps and improve clinical management of both OP/OF and HPI-related disorders.

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Section: Hpi-induced Upper Gut Diseases and Osteoporotic Fracturesmentioning

confidence: 99%

Section: Hpi-induced Upper Gut Diseases and Osteoporotic Fracturesmentioning

confidence: 99%

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Fisher

Smith

2020

JCM

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“…[ 66 ]. The impairment of bone health has been shown in both Caucasian [ 70 ] and Asian cohorts [ 67 , 75 , 77 ]. In particular, Lee et al described the increase risk of hip fractures in PPIs users/BP nonusers in comparison with PPIs/BP nonusers in a large cohort of Korean subjects (OR: 1.34, 95% CI 1.24–1.44).…”

Section: Potential Mechanisms Of Ppis Induced Fracture Riskmentioning

confidence: 99%

“…Very recently, in another cohort of Korean population, Park et al evaluated 8,903 elderly women suffering osteoporotic fractures and 44,515 matched controls without fractures between 2009 and 2015. Short- and long-term PPIs use showed a positive association with the risk of osteoporotic fracture (OR: 1.3, 95% CI 1.09–1.56 and OR: 1.31, 95% CI 1.23–1.38, respectively), and cumulative dose did not show any influence over fracture risk [ 75 ].…”

Section: Potential Mechanisms Of Ppis Induced Fracture Riskmentioning

confidence: 99%

Proton Pump Inhibitors and Fractures in Adults: A Critical Appraisal and Review of the Literature

Briganti

Naciu

Tabacco

et al. 2021

International Journal of Endocrinology

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Despite the large number of patients worldwide being on proton pump inhibitors (PPIs) for acid-related gastrointestinal disorders, uncertainty remains over their long-term safety. Particularly, the potential side effects of these drugs on bone health have been evaluated in the last years. The purpose of our narrative review is to gather and discuss results of clinical studies focusing on the interactions between PPIs and fracture risk. Data generated mainly from nested case-control studies and meta-analysis suggest that long-term/high-dose PPIs users are characterized by an increased risk of fragility fractures, mainly hip fractures. However, in these studies, the PPIs-induced bone impairment is often not adjusted for different confounding variables that could potentially affect bone health, and exposure to PPIs was reported using medical prescriptions without adherence evaluation. The mechanisms of the PPI-related bone damage are still unclear, but impaired micronutrients absorption, hypergastrinemia, and increased secretion of histamine may play a role. Clinicians should pay attention when prescribing PPIs to subjects with a preexistent high risk of fractures and consider antiosteoporotic drugs to manage this additive effect on the bone. However, further studies are needed to clarify PPIs action on the bone.

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“…Em observações de IBPs individuais foi relacionado omeprazol. Em síntese, os autores destacam que embora as fraturas sejam pequenas, os riscos de fraturas são significativamente relevantes na escolha de IBPs para o tratamento em crianças.ParaPark et al (2020), em seu estudo caso-controle aninhado com mais de 350.000 pacientes coreanos com DRGE e úlcera péptica no período de janeiro de 2006 a dezembro de 2015, cujo objetivo foi investigar o risco de fraturas osteoporóticas em usuários de IBP em comparação com usuários de ARH2 e a associação entre fraturas e a duração e uso regular de IBP. Após os critérios de exclusão, foram excluídos aqueles com <50 anos de idade, com uso de serviço médico devido a câncer, síndrome de imunodeficiência adquirida, ou osteoporose dentro de 1 ano antes de entrar na coorte; ou que tenham um diagnóstico de fratura osteoporótica (coluna: S220, 221, 320, 327, M484, 485; úmero proximal: S422, 423; fêmur: S72; rádio distal: S525, 526) dentro de 1 ano antes da entrada na coorte.…”

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Lupus Eritematoso Sistemico E Anomalias Carotídeas Como Fator De Risco Para Acidente Vascular Encefálico

Marques¹,

Pollo²,

Pântano³

et al. 2021

Ciências Médicas: Campo Teórico, Métodos, Aplicabilidade E Limitações 2

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Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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Comparative analysis of the risk of osteoporotic fractures with proton pump inhibitor use and histamine-2 receptor antagonist therapy in elderly women: A nationwide population-based nested case-control study

Cited by 12 publications

References 52 publications

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Proton Pump Inhibitors and Fractures in Adults: A Critical Appraisal and Review of the Literature

Lupus Eritematoso Sistemico E Anomalias Carotídeas Como Fator De Risco Para Acidente Vascular Encefálico

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