Comparative analysis of the neurula transcriptomes of two species of flatfishes: Platichthys stellatus and Paralichthys olivaceus

Fang, Wei; Chen, Jie; Chen, Xinye; Bao, Baolong

doi:10.1016/j.gene.2016.10.020

Cited by 7 publications

(3 citation statements)

References 35 publications

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“…First, there is moderate heritability for direction of asymmetry, where the majority of the variation in asymmetry direction in offspring is explained by parental direction phenotype (Policansky, , Boklage, , Bergstrom unpublished data). Some candidate genes for asymmetry direction have been identified (Hashimoto et al, ; Wei, Chen, Chen, & Bao, ) although there are likely multiple loci and environmental influences involved. Second, there is a geographical cline in the relative frequency of sinistral and dextral individuals across the species' distribution in the north Pacific (Hubbs & Kuronuma, ) that has persisted for at least decades (Bergstrom, ), suggestive of a selective environmental gradient (Endler, ).…”

Section: Introductionmentioning

confidence: 99%

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Polymorphism and multiple correlated characters: Do flatfish asymmetry morphs also differ in swimming performance and metabolic rate?

Bergstrom

Alba

Pacheco

et al. 2019

Ecology and Evolution

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Phenotypic polymorphisms often differ in multiple correlated traits including morphology, behavior, and physiology, all of which can affect performance. How selection acts on these suites of traits can be complex and difficult to discern. Starry flounder ( Platichthys stellatus ) is a pleuronectid flatfish that exhibits rare polymorphism for the direction of eye migration and resulting whole‐body asymmetry. P. stellatus asymmetry morphs differ subtly in several anatomical traits, foraging behavior, and stable isotope signatures, suggesting they may be ecologically segregated, yet performance and metabolic differences are unknown. Here we tested the hypothesis that sinistral and dextral P. stellatus asymmetry morphs diverge in performance and routine metabolic rate (RMR) by comparing prolonged swimming endurance (time to exhaustion at a constant swimming speed), fast‐start swimming velocity and acceleration, and rate of oxygen consumption. Based on subtle morphological differences in caudal tail size, we expected sinistral P. stellatus to have superior prolonged swimming endurance relative to dextral fish, but inferior fast‐start performance. Sinistral P. stellatus exhibited both significantly greater prolonged swimming performance and fast‐start swimming performance. However, sinistral P. stellatus also exhibited greater RMR, suggesting that their general swimming performance could be enhanced by an elevated metabolic rate. Divergence between P. stellatus asymmetry morphs in swimming performance and metabolic rates contributes to growing evidence of ecological segregation between them, as well as our understanding of possible ecological consequences of asymmetry direction in flatfishes. These data provide an example of the complexity of polymorphisms associated with multiple correlated traits in a rare case of asymmetry polymorphism in a marine flatfish species.

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Section: Introductionmentioning

confidence: 99%

“…Some candidate genes for asymmetry direction have been identified (Hashimoto et al, 2007;Wei, Chen, Chen, & Bao, 2017) although there are likely multiple loci and environmental influences involved.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism and multiple correlated characters: Do flatfish asymmetry morphs also differ in swimming performance and metabolic rate?

Bergstrom

Alba

Pacheco

et al. 2019

Ecology and Evolution

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“…Looking more closely, at the phylotypic stage we found TF motifs strongly correlated with early development (e.g., SOX family, RARa, THRb). Focusing on pre-metamorphic and climax stages as a single set, we observed interesting overlapping TF motifs: Otx2, involved in eye development as a possible recapitulation of early development to allow eye migration 29 or Twist2, potential player in the remodeling of existing organs in Xenopus metamorphosis 30 . Motifs for TF important for the activation of myogenesis during metamorphosis (e.g., Myf5, MyoG, RUNX) were identinfied in the climax-specific peaks.…”

Section: Atac-sequencing Quality Controlmentioning

confidence: 98%

Genome-wide chromatin accessibility and gene expression profiling during flatfish metamorphosis

et al. 2023

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Metamorphosis is a widely studied post-embryonic process in which many tissues undergo dramatic modifications to adapt to the new adult lifestyle. Flatfishes represent a good example of metamorphosis in teleost fishes. During metamorphosis of flatfish, organ regression and neoformation occur, with one of the most notable changes being the migration of one of the eyes to the other side of the body. In order to create a useful and reliable tool to advance the molecular study of metamorphosis in flatfish, we generated a chromatin accessible atlas as well as gene expression profile during four developmental stages ranging from a phylotypic to a post-metamorphic stage. We identified 29,019 differentially accessible chromatin regions and 3,253 differentially expressed genes. We found stage-specific regulatory regions and gene expression profiles, supporting the quality of the results. Our work provides strongly reproducible data for further studies to elucidate the regulatory elements that ensure successful metamorphosis in flatfish species.

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Evolutionary Origin of Left-Right Eye Asymmetry

Bao

2022

Flatfish Metamorphosis

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Comparative analysis of the neurula transcriptomes of two species of flatfishes: Platichthys stellatus and Paralichthys olivaceus

Cited by 7 publications

References 35 publications

Polymorphism and multiple correlated characters: Do flatfish asymmetry morphs also differ in swimming performance and metabolic rate?

Polymorphism and multiple correlated characters: Do flatfish asymmetry morphs also differ in swimming performance and metabolic rate?

Genome-wide chromatin accessibility and gene expression profiling during flatfish metamorphosis

Evolutionary Origin of Left-Right Eye Asymmetry

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