Comparative Analysis of the Effects of Dorzolamide and Latanoprost on Ocular Hemodynamics in Normal Tension Glaucoma Patients

Abstract

Dorzolamide, unlike latanoprost, significantly reduced AVP times in the superior temporal retina in normal tension glaucoma (NTG) patients.

The clinical utility of colour Doppler imaging

“…In multiple studies, we also failed to detect significant changes in CDI parameters. [2][3][4][5] The present findings support the existing literature suggesting that arterio-venous passage times are more sensitive to changes in retinal haemodynamics than CDI.…”

Glaucoma de pressão normal

“…Outros estudos demonstram um provável benefício para a hemodinâmica ocular da aplicação tópica da unoprostona, com potencial efeito anti-endotelina-1 e conseqüente inibição da constricção arteriolar retiniana (107)(108) ; do betaxolol, com potencial ação bloqueadora de canais de cálcio; e da dorzolamida, com potencial efeito na aceleração da circulação retiniana (99,(109)(110) . Em estudo com as drogas beta-bloqueadoras comumente prescritas no Brasil, foi demonstrado aumento estatisticamente significante no fluxo sangüíneo ocular com o uso de betaxolol, timolol e levobunolol, tendo sido maior com as duas últimas substâncias (111) .…”

Clinical utility and differential effects of prostaglandin analogs in the management of raised intraocular pressure and ocular hypertension

“…The 24-hour diurnal IOP was statistically lower with bimatoprost compared with latanoprost in a double-masked cross-over comparison (n = 42), although the difference was small and latanoprost better tolerated with regard to conjunctival hyperemia. 41 However, for NTG a meta-analysis 169 found IOP reduction was greatest for brimonidine (24%), followed by bimatoprost (21%), latanoprost (20%), timolol (15%), and dorzolamide (14%) at peak, and greatest for latanoprost (20%), followed by timolol (18%) and bimatoprost (18%), dorzolamide (12%), and brimonidine (11%) at trough. Ten of the 15 trials involved a PGA.…”

“…Ten of the 15 trials involved a PGA. 44,53,56,103,114,169,[170][171][172][173] Subjects (n = 1571) switched to latanoprost from previous glaucoma monotherapy and fixed and unfixed combination therapies maintained IOP to an acceptable level through a 2-year period. 174 Latanoprost-insensitive patients developed IOP lowering with bimatoprost in a randomized prospective study with two 30-day treatment phase and 30-day washout phase.…”

“…162 %IOPR may be superior for brimonidine than PGA for NTG. 169 PGAs are as effective for IOP-lowering at night-time as for day-time.…”