Comparative analysis of the chemical and biochemical synthesis of keto acids

Luo, Zhengshan; Yu, Shiqin; Zeng, Weizhu; Zhou, Jingwen

doi:10.1016/j.biotechadv.2021.107706

Cited by 38 publications

(21 citation statements)

References 270 publications

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“…Here, interest was targeted to organic acids with application in polymer synthesis (i.e., 3-hydropropionic, adipic, fumaric, itaconic, lactic, malic, and succinic acid), the largest segment in the chemical industry [11]. Two additional building block organic acids that can be obtained from lignocellulose, namely levulinic and furan dicarboxylic acid, were excluded from this review since their production relies exclusively or mainly on chemical treatment of C 6 monosaccharides derived from biomass: (i) levulinic acid is currently produced through acid treatment of sugars [68]; (ii) fermentative production of furan dicarboxylic acid has been reported through bioconversion of 5-hydroxymethyl furfuraldehyde, which is obtained by acid treatment of sugars [69]. The development of a new industrial process for production of a chemical must fulfill several requirements, such as high titer, productivity, and yield.…”

Section: 1%mentioning

confidence: 99%

Current Progress in Production of Building-Block Organic Acids by Consolidated Bioprocessing of Lignocellulose

Mazzoli

2021

Fermentation

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Several organic acids have been indicated among the top value chemicals from biomass. Lignocellulose is among the most attractive feedstocks for biorefining processes owing to its high abundance and low cost. However, its highly complex nature and recalcitrance to biodegradation hinder development of cost-competitive fermentation processes. Here, current progress in development of single-pot fermentation (i.e., consolidated bioprocessing, CBP) of lignocellulosic biomass to high value organic acids will be examined, based on the potential of this approach to dramatically reduce process costs. Different strategies for CBP development will be considered such as: (i) design of microbial consortia consisting of (hemi)cellulolytic and valuable-compound producing strains; (ii) engineering of microorganisms that combine biomass-degrading and high-value compound-producing properties in a single strain. The present review will mainly focus on production of organic acids with application as building block chemicals (e.g., adipic, cis,cis-muconic, fumaric, itaconic, lactic, malic, and succinic acid) since polymer synthesis constitutes the largest sector in the chemical industry. Current research advances will be illustrated together with challenges and perspectives for future investigations. In addition, attention will be dedicated to development of acid tolerant microorganisms, an essential feature for improving titer and productivity of fermentative production of acids.

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Section: 1%mentioning

confidence: 99%

Current Progress in Production of Building-Block Organic Acids by Consolidated Bioprocessing of Lignocellulose

Mazzoli

2021

Fermentation

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“…Nevertheless, poor economic performance, resulting from the high cost of raw materials, and low yields represent the major limitations associated with two previously reported sugar acid dehydration methods, despite the minimal addition of oxygen. 30,31…”

Section: Introductionmentioning

confidence: 99%

“…25 Moreover, 2KGA is cheaper than other sugar acids. 31 Meanwhile, 2KGA has been used only for vitamin C production, so there is an urgent need to expand its utility to other applications. In this study, 2KGA was chosen as the substrate for use in various dehydration systems to increase the yield of furan compounds.…”

Section: Introductionmentioning

confidence: 99%

Application of sugar-containing biomass: one-step synthesis of 2-furylglyoxylic acid and its derivatives from a vitamin C precursor

et al. 2022

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“…With the development of synthetic biology, chemical and material products are increasingly being obtained by microbial synthesis ( McCarty and Ledesma-Amaro, 2019 ; Luo et al, 2021 ). These products are mainly obtained through microbial fermentation using food materials (glucose, sucrose, and starch) as substrates ( Qiu et al, 2017 ; Jiang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Metabolic Engineering of Bacillus amyloliquefaciens to Efficiently Synthesize L-Ornithine From Inulin

Zhu

Hu²,

Yan³

et al. 2022

Front. Bioeng. Biotechnol.

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Bacillus amyloliquefaciens is the dominant strain used to produce γ-polyglutamic acid from inulin, a non-grain raw material. B. amyloliquefaciens has a highly efficient tricarboxylic acid cycle metabolic flux and glutamate synthesis ability. These features confer great potential for the synthesis of glutamate derivatives. However, it is challenging to efficiently convert high levels of glutamate to a particular glutamate derivative. Here, we conducted a systematic study on the biosynthesis of L-ornithine by B. amyloliquefaciens using inulin. First, the polyglutamate synthase gene pgsBCA of B. amyloliquefaciens NB was knocked out to hinder polyglutamate synthesis, resulting in the accumulation of intracellular glutamate and ATP. Second, a modular engineering strategy was applied to coordinate the degradation pathway, precursor competition pathway, and L-ornithine synthesis pathway to prompt high levels of intracellular precursor glutamate for l-ornithine synthesis. In addition, the high-efficiency L-ornithine transporter was further screened and overexpressed to reduce the feedback inhibition of L-ornithine on the synthesis pathway. Combining these strategies with further fermentation optimizations, we achieved a final L-ornithine titer of 31.3 g/L from inulin. Overall, these strategies hold great potential for strengthening microbial synthesis of high value-added products derived from glutamate.

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Comparative analysis of the chemical and biochemical synthesis of keto acids

Cited by 38 publications

References 270 publications

Current Progress in Production of Building-Block Organic Acids by Consolidated Bioprocessing of Lignocellulose

Current Progress in Production of Building-Block Organic Acids by Consolidated Bioprocessing of Lignocellulose

Application of sugar-containing biomass: one-step synthesis of 2-furylglyoxylic acid and its derivatives from a vitamin C precursor

Metabolic Engineering of Bacillus amyloliquefaciens to Efficiently Synthesize L-Ornithine From Inulin

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