Comparative Analysis of the Action of Butyrylperazine at Manhattan State Hospital and the University Psychiatric Clinic at Erlangen

Bente, D; Rajotte, Paul

doi:10.1176/ajp.119.3.203

Cited by 17 publications

(3 citation statements)

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“…While earlier reports suggested that Europeans received lower dosages of several neuroleptics as compared to Americans (Heilizer 1960;Collard 1962;Denber, Bente and Rajotte 1962;Denber and Bente 1967;Murphy 1974), the majority of recent studies indicate that patients from non-Western countries, such as Turkey (Itil 1975), India and Pakistan (Allen, Rack and Vaddadi 1977;Lewis, Rack, Vaddadi et al 1980), China, 2 Japan, Malaysia and Indonesia (Murphy 1969(Murphy , 1974Olatawara 1978;Okuma 1981), were clinically improved at a much lower average dosage level of neuroleptics, as compared to Americans and Europeans. While earlier reports suggested that Europeans received lower dosages of several neuroleptics as compared to Americans (Heilizer 1960;Collard 1962;Denber, Bente and Rajotte 1962;Denber and Bente 1967;Murphy 1974), the majority of recent studies indicate that patients from non-Western countries, such as Turkey (Itil 1975), India and Pakistan (Allen, Rack and Vaddadi 1977;Lewis, Rack, Vaddadi et al 1980), China, 2 Japan, Malaysia and Indonesia (Murphy 1969(Murphy , 1974Olatawara 1978;Okuma 1981), were clinically improved at a much lower average dosage level of neuroleptics, as compared to Americans and Europeans.…”

Section: Neurolepticsmentioning

confidence: 99%

Ethnicity and psychopharmacology

1986

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In clinical studies and cross-national surveys, cultural or ethnic factors have been found to be significant determinants in patients' responses to psychotropic medication. Dosage requirements and the potential for toxic reactions might differ amongst racial and ethnic groups. In this paper, the authors review the relevant literature and examine pharmacodynamic, pharmacokinetic and cultural-psychological factors, all of which could be responsible for such ethnic variations.

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Section: Neurolepticsmentioning

confidence: 99%

Ethnicity and psychopharmacology

1986

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“…Average daily dose requirements of the antipsychotic butyrylperazine were five times higher in New York than in a matched patient sample in Germany (Denber et al, 1962).…”

Section: Introductionmentioning

confidence: 70%

“…There are only limited cross-ethnic studies of interindividual differences in psychotropic drug metabolism. Average daily dose requirements of the antipsychotic butyrylperazine were five times higher in New York than in a matched patient sample in Germany (Denber et al, 1962).…”

Section: Introductionmentioning

confidence: 70%

Desipramine pharmacokinetics in Chinese and Caucasian volunteers.

Mv¹,

Ea²,

Chang³

et al. 1984

Brit J Clinical Pharma

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In order to better define the role of pharmacokinetic variation in reported cross‐ethnic differences in dosing patterns of some psychoactive drugs, single dose kinetics of the tricyclic antidepressant desipramine (DMI) were studied in 14 Chinese and 16 Caucasian healthy volunteers. DMI and 2‐OH‐DMI concentrations were assayed with h.p.l.c. in serial plasma and 24 h urine samples over 5 days following an oral 100 mg dose of DMI. Mean total clearance of DMI (CLDMI) from plasma was significantly (P less than 0.05) higher in the Caucasians (123 +/‐ 57 l/h) than in the Chinese (73.5 +/‐ 38.8 l/h). There was no significant difference in the apparent clearance of DMI by hydroxylation, fraction of dose metabolized to the hydroxy metabolite, DMI t1/2 or plasma protein binding between the two groups. Trimodal distribution of CLDMI was found, with 4/14 (29%) Chinese demonstrating slow CL (less than 33 l/h) and 4/16 (25%) Caucasians rapid CL (greater than 195 l/h). Correcting CL values for the greater mean weight of the Caucasians did not alter the pattern of distribution. CLDMI did not correlate with body weight. Although environmental factors cannot be ruled out, these results are consistent with genetically based differences in hepatic metabolism, probably affecting pathways in addition to hydroxylation, and suggest that 30% of Orientals would be at risk for toxicity from routine doses of tricyclics or similarly metabolized drugs.

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Clinical Psychopharmacological Research: Problems, Questions, and Some Suggestions in Analyzing Reports

Benor

Ditman²

1967

The Journal of Clinical Pharmacology and The Journal of New Dru

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Comparative Analysis of the Action of Butyrylperazine at Manhattan State Hospital and the University Psychiatric Clinic at Erlangen

Cited by 17 publications

References 0 publications

Ethnicity and psychopharmacology

Ethnicity and psychopharmacology

Desipramine pharmacokinetics in Chinese and Caucasian volunteers.

Clinical Psychopharmacological Research: Problems, Questions, and Some Suggestions in Analyzing Reports

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