Comparative Analysis of SARS-CoV-2 Reproduction Rates in the Dialysis and General Populations

Cherif, Alhaji; Willetts, Joanna; Usvyat, Len; Wang, Yuedong; Kotanko, Peter

doi:10.1681/asn.2020121691

Cited by 8 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results indicate a significant correlation between general population and incenter hemodialysis patient seropositivity rates for SARS-CoV-2 infection and support the notion that COVID-19 in in-center maintenance HD patients is primarily driven by infections in the patients' residence area. 4 The lower seropositivity rates in dialysis staff compared to patients points towards the effectiveness of screening measures and efforts to limit transmission in dialysis centers.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

SARS-CoV-2 Seropositivity Rates in Patients and Clinical Staff in New York City Dialysis Facilities: Association With the General Population

et al. 2021

Self Cite

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

SARS-CoV-2 Seropositivity Rates in Patients and Clinical Staff in New York City Dialysis Facilities: Association With the General Population

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Besides, in-center hemodialysis is associated with a higher risk of contact with health care professionals or other high-risk patients, which may explain the elevated incidence of coronavirus disease 2019 (COVID-19) observed in dialysis patients in early 2020 (4,5). To limit the transmission rate, infection prevention steps have been progressively taken in dialysis centers during the successive waves of the pandemic (4,6). Although these measures certainly had a major role in limiting disease transmission, precise quantification of their effect is lacking.…”

Section: Introductionmentioning

confidence: 99%

Vaccination and COVID-19 Dynamics in Dialysis Patients

Karoui

Hourmant

Ayav

et al. 2022

CJASN

View full text Add to dashboard Cite

Background and objectivesDialysis patients have a high mortality risk after coronavirus disease 2019 (COVID-19) and an altered immunologic response to vaccines, but vaccine clinical effectiveness remains unknown in this population.Design, setting, participants, & measurementsUsing Bayesian multivariable spatiotemporal models, we estimated the association between vaccine exposure and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe infections (with hospital admission) in dialysis patients from simultaneous incidence in the general population. For dialysis patients, cases were reported within the French end-stage kidney disease REIN registry from March 11, 2020, to April 29, 2021, and vaccine exposure (first dose) was reported in weekly national surveys since January 2021. Cases in the general population were obtained from the national exhaustive inpatient surveillance system (SI-VIC database), and vaccination coverage (first dose) was obtained from the national surveillance system (VAC-SI database).ResultsDuring the first wave, incidence in dialysis patients was approximately proportional to the general population. However, we showed a lower relative incidence for dialysis patients during the second wave (compared with that observed in nondialysis patients), suggesting an effect of prevention measures. Moreover, from the beginning of the vaccination rollout, incidence in dialysis patients was lower compared with predictions based on the first and second waves. Adding vaccination coverages in dialysis and nondialysis patients as predictors allowed the reported cases to be fit correctly (3685 predicted cases, 95% confidence interval, 3552 to 3816, versus 3620 reported). Incidence rate ratios were 0.37 (95% confidence interval, 0.18 to 0.71) for vaccine exposure in dialysis patients and 0.50 (95% confidence interval, 0.40 to 0.61) per 10% higher in vaccination coverage in the same-age general population, meaning that vaccine exposure in dialysis patients and the general population was independently associated with lower hospitalization rate of dialysis patients.ConclusionsOur findings suggest that vaccination may yield a protective effect against severe forms of COVID-19 in dialysis patients, despite altered immunologic vaccine responses.

show abstract

“…Since the early pandemic, epidemiological studies suggested that SARS-CoV-2 basic reproduction number (R0) increases linearly with population density [ 16 ] and this was why clusters were observed in crowded and confined spaces, mass gatherings, and populous metropolitan areas [ 17 , 18 ]. More recently, a study by Cherif A et al, demonstrated that the COVID19 reproductive rate R(t) was comparable between dialysis and general population [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of SARS-CoV-2 antibodies in hemodialysis patients in Senegal: a multicenter cross-sectional study

et al. 2021

View full text Add to dashboard Cite

Background Hemodialysis patients are among high-risk groups for COVID-19. Africa is the continent with the lowest number of cases in the general population but we have little information about the disease burden in dialysis patients. Objectives This study aimed to describe the seroprevalence of SARS-CoV-2 antibodies in the hemodialysis population of Senegal. Patients and methods We conducted a multicenter cross-sectional survey, between June and September 2020 involving 10 public dialysis units randomly selected in eight regions of Senegal. After seeking their consent, we included 303 patients aged ≥ 18 years and hemodialysis for ≥ 3 months. Clinical symptoms and biological parameters were collected from medical records. Patients’ blood samples were tested with Abbott SARS-CoV-2 Ig G assay using an Architect system. Statistical tests were performed with STATA 12.0. Results Seroprevalence of SARS-CoV-2 antibodies was 21.1% (95% CI = 16.7–26.1%). We noticed a wide variability in SARS-CoV-2 seroprevalence between regions ranging from 5.6 to 51.7%. Among the 38 patients who underwent nasal swab testing, only six had a PCR-confirmed infection and all of them did seroconvert. Suggestive clinical symptoms were reported by 28.1% of seropositive patients and the majority of them presented asymptomatic disease. After multivariate analysis, a previous contact with a confirmed case and living in a high population density region were associated with the presence of SARS-CoV-2 antibodies. Conclusion This study presents to our knowledge the first seroprevalence data in African hemodialysis patients. Compared to data from other continents, we found a higher proportion of patients with SARS-CoV-2 antibodies but a lower lethality rate.

show abstract

Comparative Analysis of SARS-CoV-2 Reproduction Rates in the Dialysis and General Populations

Cited by 8 publications

References 3 publications

SARS-CoV-2 Seropositivity Rates in Patients and Clinical Staff in New York City Dialysis Facilities: Association With the General Population

SARS-CoV-2 Seropositivity Rates in Patients and Clinical Staff in New York City Dialysis Facilities: Association With the General Population

Vaccination and COVID-19 Dynamics in Dialysis Patients

Prevalence of SARS-CoV-2 antibodies in hemodialysis patients in Senegal: a multicenter cross-sectional study

Contact Info

Product

Resources

About