Comparative analysis of rhesus macaque and human placental organoids highlights evolutionary differences in placentation
Allyson Caldwell,
Liheng Yang,
Elizabeth A. Scheef
et al.
Abstract:Throughout evolution, the placenta has diversified in both structure and cellular composition while maintaining its fundamental function. Trophoblasts are fetal-derived cells responsible for nourishing and protecting the developing fetus and are a universal component of all placentas. While primate placentas exhibit many shared morphological features, species-specific differences in gene expression remain largely unexplored, primarily due to the lack of suitable in vitro models. To address this gap, we develop… Show more
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