Comparative analysis of primary and secondary glomerulopathies in the northeast of
            Brazil: data from the Pernambuco Registry of Glomerulopathies - REPEG

Costa, Denise Maria do Nascimento; Valente, Lucila Maria; Gouveia, Pedro Alves da Cruz; Sarinho, Filipe Wanick; Vajgel, Gisele; Cavalcante, Maria Alina Gomes de Mattos; Oliveira, Camila Barbosa Lyra de; Vasconcelos, Carolina de Andrade Jordão de; Sarinho, Emanuel

doi:10.5935/0101-2800.20170005

Cited by 16 publications

(18 citation statements)

References 19 publications

(47 reference statements)

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“…As in other studies, primary glomerulopathies corresponded to the most frequent lesions, with FSGS being the most prevalent and found in 28.8% of cases. 17,18 These data are in line with those report- Lupus nephropathy was the most common type of secondary glomerulopathy found, corresponding to 42.4% of cases. The low prevalence of diabetic nephropathy in our sample stems from the fact that we only biopsied diabetic nephropathy patients when they presented with a high degree of atypia.…”

Section: Discussionsupporting

confidence: 92%

Most common histopathological patterns of the Minas Gerais Association of the Centers of Nephrology

Machado¹,

Quadros

Watanabe³

et al. 2019

Rev. Assoc. Med. Bras.

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SUMMARY INTRODUCTION: We analyzed the distribution and frequency of glomerular diseases in patients biopsied between 1992 and 2016 in centers that make up the AMICEN (Minas Gerais Association of Nephrology Centers). METHODS: We analyzed the biopsy reports of patients from 9 AMICEN nephrology centers. We took note of their age, gender, ultrasound use, post-biopsy resting time, whether the kidney was native or a graft, number of glomeruli and indication for the biopsy. The kidney biopsy findings were broken down into four categories: glomerular and non-glomerular diseases, normal kidneys and insufficient material for analysis. Those patients diagnosed with glomerular diseases were further divided into having primary or secondary glomerular diseases. RESULTS: We obtained 582 biopsy reports. The median age was 38 years (1 to 85). The number of glomeruli varied between 0 and 70 (median = 13.0). In total, 97.8% of the biopsies were ultrasound guided. The main indication was nephrotic syndrome (36.9%), followed by hematuria-proteinuria association (16.2%). Primary glomerular diseases proved to be the most frequent (75.3%), followed by secondary diseases (24.7%). Among the primary glomerular diseases, FSGS was found at a higher frequency (28.8%), while among the secondary diseases, SLE was the most prevalent (42.4%). Regarding prevalence findings, those for both primary and secondary diseases were similar to those found in the large Brazilian registries published thus far. CONCLUSION: Glomerular disease registries are an important tool to identify the prevalence of such disease in regions of interest and can serve as an instrument to guide public policy decisions concerning the prevention of terminal kidney diseases.

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Section: Discussionsupporting

confidence: 92%

Most common histopathological patterns of the Minas Gerais Association of the Centers of Nephrology

Machado¹,

Quadros

Watanabe³

et al. 2019

Rev. Assoc. Med. Bras.

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“…In Brazil, IMN and LMN were evaluated as the main causes of MN [3]. However, clinical characteristics such as age and sex may not be comparable between these 2 etiologies, since it is known that IMN is more prevalent in middle-aged men and LMN in younger women [2,47]. Race was not categorized, as in other studies, since assessment based only on skin color is extremely inaccurate in Brazilian population, as demonstrated in a study that used 12 ancestry markers in this population [48].…”

Section: Resultsmentioning

confidence: 99%

“…Idiopathic membranous nephropathy (IMN) is one of the leading causes of nephrotic syndrome worldwide, and is responsible for around 20% of all cases [1]. It is also the second most prevalent primary glomerular disease in northeastern Brazil [2]. Among the secondary forms, systemic lupus erythematosus (SLE) is the most frequent [3].…”

Section: Introductionmentioning

confidence: 99%

<b><i>Mannose-Binding Lectin2</i></b> Gene Polymorphism and IgG4 in Membranous Nephropathy

Costa¹,

Valente²,

Vajgel³

et al. 2018

Nephron

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Background: Idiopathic membranous nephropathy (IMN) has been linked to the lectin pathway, IgG4 and genetic susceptibility. We investigated the frequency of mannose-binding lectin2 (MBL2) gene polymorphisms and the serum ratio of IgG4 in patients with membranous nephropathy (MN). Methods: Polymorphisms in the exon 1 of the MBL2 gene (codons 52, 54, and 57) and single base polymorphisms at positions -550 (HL) and -221 (XY) in the promoter region were evaluated in 60 patients compared to a control group (CG) of 101 blood donors. It established the frequency of polymorphisms and the serum ratio of IgG4 comparing 2 etiologies of MN: idiopathic (35 patients) and secondary to systemic lupus erythematosus (25 patients). Results: Patients with MN had a 2.54-fold higher probability (95% CI 1.51-4.31) of carrying the O alelle, exon 1 variant, and 11.16-fold higher probability (95% CI 4.77-28.41) of having A/O genotype when compared to CG. The frequency of polymorphisms in the promoter region was similar between the groups. Combined genotypes generally related to the defective production of MBL (YA/O, XA/O and O/O) were more frequent in patients with MN (OR 7.11;), when compared to controls. The median of serum ratio IgG4 was 5% for idiopathic MN and 3% for lupus MN patients (p = 0.016). Conclusions: Our data suggests that MBL2 polymorphisms may be associated with the activation of the lectin pathway by IgG4 subclass antibodies in MN.

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“…Microscopic evaluation is crucial for diagnosis, since it provides prognostic data and guidance for treatment. In Brazil, glomerulopathies are among the leading causes of end-stage kidney disease (ESKD), and account for 11% of patients on dialysis [1]. In 2016, nearly 125,000 people in the USA started treatment for ESKD [2].…”

Section: Introductionmentioning

confidence: 99%

Application of geostatistical functions and deep features to kidney biopsy images to differentiate focal segmental glomerulosclerosis from minimal change disease

Santos¹,

Silva²,

Veras³

2020

Anais Estendidos Da Conference on Graphics, Patterns and Images (SIBRAPI Estendido 2020)

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Chronic kidney diseases arise from acute or intermittent pathologies that have not been adequately treated, such as minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). The accurate identification of these two diseases is of paramount importance, because their treatments and prognoses are different. Thus, we propose a method that is capable of differentiating MCD from FSGS based on images from pathological examinations. In the proposed method, we use four pre-trained convolutional neural networks and geostatistical functions to extract image features. Of the 8,720 extracted features, we selected 94 based on mutual information criteria, and in the classification step, we used a random forest classifier. The proposed method obtained an accuracy of 94.3% and Kappa index of 87.9%, a level that is regarded as “almost perfect”, confirming that our method is very promising.

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Comparative analysis of primary and secondary glomerulopathies in the northeast of Brazil: data from the Pernambuco Registry of Glomerulopathies - REPEG

Cited by 16 publications

References 19 publications

Most common histopathological patterns of the Minas Gerais Association of the Centers of Nephrology

Most common histopathological patterns of the Minas Gerais Association of the Centers of Nephrology

<b><i>Mannose-Binding Lectin2</i></b> Gene Polymorphism and IgG4 in Membranous Nephropathy

Application of geostatistical functions and deep features to kidney biopsy images to differentiate focal segmental glomerulosclerosis from minimal change disease

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