Comparative analysis of polypeptides in the heat shock proteins synthesized in the myocardium of Wistar and August rats

Abstract

The use of two-dimensional electrophoresis to study the polypeptide composition of heat shock proteins 70 synthesized in the myocardium of Wistar and August rats in response to thermal stress and repetitive immobilization stress revealed interstrain differences in the composition of stimulated polypeptides in these proteins. The differences are mainly due to differential expression of the heat shock protein gene(s) encoding polypeptides with pI 6.2-6.0 in the two strains. The drastically reduced levels of the synthesis and/or accumulation of some heat shock proteins 70 in the hearts of August rats are associated with their failure to develop cardioprotective phenomena in response to repetitive immobilization stress.

Protein content in rat brain neurons predisposed and resistant to emotional stress

“…This problem has been extensively discussed [4,6,[8][9][10]12]. In August and Wistar rats, cardiovascular system [6], lymphoid and connective tissue [9], production and accumulation of heat shock protein 70 in the myocardium [5] differently react to stress. August and Wistar rats differ by the cerebral content of endogenous peptides (substance P, 5-sleep peptide, and fS-endorphine) [8,12] and by biogenic amine metabolism [4,6].…”