Comparative analysis of physicochemical properties, bioequivalence, safety and tolerability of the first domestic semaglutide
A. S. Ametov,
I. E. Shokhin,
E. A. Rogozhina
et al.
Abstract:Semaglutide is a representative of analogues of the incretin hormone human glucagon-like peptide-1 (GLP-1) and is currently used in Russia for the treatment of type 2 diabetes mellitus (T2DM; in monotherapy and in combination therapy), including patients with obesity and overweight.The aim of the work was to conduct a comparative assessment of the physicochemical properties, a biological activity, bioequivalence and safety, including tolerability and immunogenicity, of the drug Quincent® (semaglutide, 1.34 mg/… Show more
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