Comparative Analysis of Oct4 in Different Histological Subtypes of Esophageal Squamous Cell Carcinomas in Different Clinical Conditions

Vaiphei, Kim; Sinha, Saroj Kant; Kochhar, Rakesh

doi:10.7314/apjcp.2014.15.8.3519

Cited by 17 publications

(18 citation statements)

References 47 publications

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“…The promotive effect of Oct4 on cancer cell proliferation was reported in certain types of cancer cells, including hepatocellular carcinoma (23) and esophageal cancer (8). The identification of Oct4-positive putative stem cells may result in uncontrolled cell proliferation and treatment failure in esophageal squamous cell carcinoma (24). The promoting effect of Oct4 on migration and invasion has also been observed in numerous types of cancer.…”

Section: A B C D Discussionmentioning

confidence: 97%

Transcription factor Oct4 promotes osteosarcoma by regulating lncRNA AK055347

et al. 2016

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Abstract. Osteosarcoma is the most common primary bone tumor in children and adolescents, typically presenting with a poor prognosis. Octamer-binding transcription factor 4 (Oct4) protein, encoded by the POU class 5 homeobox 1 gene, is important in maintaining self-renewal of pluripotent stem cells, and is closely associated with cancer. However, its role in osteosarcoma remains to be elucidated. The present study observed Oct4 was markedly increased in osteosarcoma cell lines and in human osteosarcoma tissue samples. Following Oct4 downregulation by small interfering RNA (siRNA) in osteosarcoma F5M2 cells, the cells exhibited significant decreases in proliferation and invasion ability, and an increase in cell apoptosis. Notably, downregulation of Oct4 decreased the expression of AK055347, a newly identified long noncoding RNA (lncRNA) in human tissues. The downregulation of AK055347 by siRNA resulted in a significant suppressive effect on proliferative and invasive ability, and promotion of cell apoptosis in osteosarcoma cells. Thus, the current study suggests Oct4 exerts a promoting effect in osteosarcoma, and identifies a novel lncRNA in osteosarcoma progression.

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Section: A B C D Discussionmentioning

confidence: 97%

Transcription factor Oct4 promotes osteosarcoma by regulating lncRNA AK055347

et al. 2016

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“…The regulatory role of CD133 (Yu et al, 2016) and CD44 (Krishnamurthy and Nör, 2012) in self-renewal of CSC and tumor progression have been reported previously. Also studies focused on the core transcription factors OCT4, SOX2 and NANOG as the prognostic CSC markers in OSCC (Chiou et al, 2008;Vaiphei et al, 2014). A significant association has been reported between the expression of OCT4, SOX2, and NANOG with the grade of OSCC (Chiou et al, 2008;Vaiphei et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Relative Expression of OCT4, SOX2 and NANOG in Oral Squamous Cell Carcinoma Versus Adjacent Non- Tumor Tissue

Naini

Aminishakib

Abdollahi

et al. 2019

Asian Pac J Cancer Prev

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Objective: Oral squamous cell carcinoma (OSCC) accounts for over 90% of oral neoplasms. Finding molecular markers for predicting prognosis is a high priority. The core transcription factors, OCT4, SOX2, and NANOG that regulate embryonic stem cell pluripotency have been implicated in progression of various malignancies. The predictive value of these markers and their role in the development of OSCC is still controversial. In this study, we therefore evaluated their expression in OSCCs and adjacent non-tumor tissue. Methods: A total of 60 frozen tumor and adjacent non-tumor tissue samples from 30 patients with OSCC were examined using quantitative reverse transcription polymerase chain reaction (qRT-PCR). Clinical and pathological data of patients including tumor stage, lymph node metastasis and tumor grade were also recorded. Results: Expression of SOX2 was significantly higher in adjacent non-tumor as compared to tumor tissue (P=0.04). No statistically significant differences were found for expression of OCT4 (P=0.50) and NANOG (P=0.68). Also, there was no significant association between expression of OCT4, SOX2, and NANOG and clinical or pathological data (P>0.05), although slightly higher values were noted in patients without lymph node metastasis. Conclusion: Based on the present data, decreased expression of SOX2 is correlated with carcinogenesis in the oral cavity and development of OSCC.

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“…Over expression of Oct-4 and Nanog genes, found in CSC-enriched subpopulation derived from HNSCC sphere formation colonies, positively correlated with treatment failure and stage while negatively correlated with differentiation status (Tsai et al, 2011;Vaiphei et al,2014). Oct-4, individually was found to be competent enough to up regulate ALDH1+ in HNSCC cells while in combination with TRA1-60 (a tumour rejection antigen) were detectable as indicators of invasiveness.…”

Section: Oct-4 Sox2 and Nanogmentioning

confidence: 95%