Comparative Analysis of MiB1 and p53 Expression in Human Bladder Tumors and Their Correlation with Cancer Progression

Pfister, Christian; Buzelin, F; Casse, Christophe; Bochereau, Ghislain; Buzelin, Jean-Marie; Bouchot, Olivier

doi:10.1159/000019580

Cited by 23 publications

(5 citation statements)

References 24 publications

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“…Our findings show that the most reliable biological prognostic factor in the superficial bladder tumors is Ki‐67 labeling index. Different results were described by Pfister et al 37. and Nakopoulou et al .,38 who found no association between Ki‐67 immunoexpression and progression.…”

Section: Discussionmentioning

confidence: 59%

Ki‐67 index enhances the prognostic accuracy of the urothelial superficial bladder carcinoma risk group classification

Santos

Amaro

Costa

et al. 2003

Intl Journal of Cancer

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Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these tumors have a strong propensity to recur and about 1/3 of them compared to disease progression. Histological assessment of these superficial tumors is not sufficiently discriminator in predicting prognosis; therefore, we decided to evaluate the prognostic significance of p53 and Ki-67 immunoexpression in low-grade (GI-II) USPC in order to predict the potential outcome of these tumors. P53 and Ki-67 immunoexpression were studied in function of recurrence-free and progression-free survival in 159 primary superficial bladder tumors. A prognostic risk model based on grade, stage and multifocality was also evaluated. P53 accumulation was significantly related to tumor progression (p‫.)600.0؍‬ High Ki-67 index (>18%) and multifocality were significantly related to recurrence (both p‫)1000.0؍‬ and progression-free survival (both p‫)1000.0؍‬ and were independent prognostic factors in the multivariate analysis. The prognostic risk model based on grade, stage and multifocality was not an efficient discriminator of outcome. Adding the Ki-67 index into the risk model, single pTa/T1-GI Ki-67 positive tumors, usually classified as low risk, were reclassified as of intermediate risk. After this reclassification, the risk group model identified a subgroup of pTa/T1-G1 with a high risk of recurrence and progression. Ki-67 index is a reliable prognostic marker in urothelial superficial bladder carcinoma and, when included into a risk profile classification of the low-grade USPC, the accuracy of the prognostic discrimination is enhanced.

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Section: Discussionmentioning

confidence: 59%

Ki‐67 index enhances the prognostic accuracy of the urothelial superficial bladder carcinoma risk group classification

Santos

Amaro

Costa

et al. 2003

Intl Journal of Cancer

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“…This result is not completely unexpected. Although there are studies suggesting a prognostic role of tumor cell proliferation in urinary bladder cancer (Lipponen et al, 1993;Liukkonen et al, 1999), there are also reports that fail to reproduce these data (Nakopoulou et al, 1998;Pfister et al, 1998). Our own previous analyses on the same set of carefully staged tumors were unable to show a convincing association of Ki67 LI with prognosis in pTa, pT1, or pT2-4 cancers (Nocito et al, 2001).…”

Section: Discussionmentioning

confidence: 93%

E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer

Oeggerli¹,

Tomovska²,

Schraml³

et al. 2004

Oncogene

142

103

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“…The new Ki-67 antibody MIB-1 and an antigen retrieval method, based on microwave heating, have made it possible to assess Ki-67 expression in sections obtained from normal paraffin blocks [27]. Recently a French group [28]published a paper comparing MIB-1 expression with ploidy and cancer progression in 83 TCC patients. The cohort, however, included also pT2–pT4 TCCs.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of MIB-1 Score, p53, EGFr, Mitotic Index and Papillary Status in Primary Superficial (Stage pTa/T1) Bladder Cancer: A Prospective Comparative Study

Liukkonen

Rajala²,

Raitanen³

et al. 1999

European Urology

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Comparative Analysis of MiB1 and p53 Expression in Human Bladder Tumors and Their Correlation with Cancer Progression

Cited by 23 publications

References 24 publications

Ki‐67 index enhances the prognostic accuracy of the urothelial superficial bladder carcinoma risk group classification

Ki‐67 index enhances the prognostic accuracy of the urothelial superficial bladder carcinoma risk group classification

E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer

Prognostic Value of MIB-1 Score, p53, EGFr, Mitotic Index and Papillary Status in Primary Superficial (Stage pTa/T1) Bladder Cancer: A Prospective Comparative Study

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