Comparative analysis of mesenchymal stem/stromal cells derived from human induced pluripotent stem cells and the cognate umbilical cord mesenchymal stem/stromal cells

Wang, Quanlei; Wang, Yuwei; Chang, Chongfei; Feilong, Ma; Peng, Dongxiu; Yang, Shuying; An, Yanru; Deng, Qiuting; Wang, Qixiao; Gao, Fei; Wang, Fei; Tang, Huiru; Qi, Xufeng; Jiang, Xiaoming; Cai, Dongqing; Zhou, Guangqian

doi:10.1016/j.heliyon.2022.e12683

Cited by 7 publications

(4 citation statements)

References 58 publications

(69 reference statements)

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“…After transplantation, AD-MSCs have demonstrated excellent potential for in vitro expansion and differentiation into various cell types 120 . Furthermore, the selection of the most appropriate MSCs source needs to be evaluated and chosen on a case-by-case basis, depending on specific clinical applications and research objectives 121 – 123 .…”

Section: Discussionmentioning

confidence: 99%

Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

Li,

Xiao,

Wang

et al. 2024

Cell Transplant

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This article presents a comprehensive review of the factors influencing the efficacy of mesenchymal stem cells (MSCs) transplantation and its association with platelet concentrates (PCs). It focuses on investigating the impact of PCs’ composition, the age and health status of platelet donors, application methods, and environmental factors on the outcomes of relevant treatments. In addition, it delves into the strategies and mechanisms for optimizing MSCs transplantation with PCs, encompassing preconditioning and combined therapies. Furthermore, it provides an in-depth exploration of the signaling pathways and proteomic characteristics associated with preconditioning and emphasizes the efficacy and specific effects of combined therapy. The article also introduces the latest advancements in the application of biomaterials for optimizing regenerative medical strategies, stimulating scholarly discourse on this subject. Through this comprehensive review, the primary goal is to facilitate a more profound comprehension of the factors influencing treatment outcomes, as well as the strategies and mechanisms for optimizing MSCs transplantation and the application of biomaterials in regenerative medicine, offering theoretical guidance and practical references for related research and clinical practice.

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Section: Discussionmentioning

confidence: 99%

Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

Li,

Xiao,

Wang

et al. 2024

Cell Transplant

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“…Consequently, iMSCs, surpassing iPSCs in quality, present broader application prospects. They inherit the advantages of iPSCs, including the ability to reprogram diverse adult cells such as those from peripheral blood, skin biopsies, and detached body surface cells (; Dupuis and Oltra, 2021 ; Wang Q. et al, 2023 ; Wu et al, 2018 ; Zhou C. et al, 2023 ). Given the potentially infinite replicative capacity of iPSCs, the source for iMSCs can be considered similarly inexhaustible.…”

Section: The Advantage and Challenge Of Induced Mesenchymal Stem Cell...mentioning

confidence: 99%

Strategies in product engineering of mesenchymal stem cell-derived exosomes: unveiling the mechanisms underpinning the promotive effects of mesenchymal stem cell-derived exosomes

Jiang,

Lv,

Shen

et al. 2024

Front. Bioeng. Biotechnol.

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Articular cartilage injuries present a significant global challenge, particularly in the aging population. These injuries not only restrict movement due to primary damage but also exacerbate elderly degenerative lesions, leading to secondary cartilage injury and osteoarthritis. Addressing osteoarthritis and cartilage damage involves overcoming several technical challenges in biological treatment. The use of induced mesenchymal stem cells (iMSCs) with functional gene modifications emerges as a solution, providing a more stable and controllable source of Mesenchymal Stem Cells (MSCs) with reduced heterogeneity. Furthermore, In addition, this review encompasses strategies aimed at enhancing exosome efficacy, comprising the cultivation of MSCs in three-dimensional matrices, augmentation of functional constituents within MSC-derived exosomes, and modification of their surface characteristics. Finally, we delve into the mechanisms through which MSC-exosomes, sourced from diverse tissues, thwart osteoarthritis (OA) progression and facilitate cartilage repair. This review lays a foundational framework for engineering iMSC-exosomes treatment of patients suffering from osteoarthritis and articular cartilage injuries, highlighting cutting-edge research and potential therapeutic pathways.

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“…Current human chemical reprogramming method was primarily conducted on human mesenchymal stem cells (MSCs) from adipose or dermis tissues 1,3 . However, umbilical cord tissue emerges as a superior alternative for several reasons: it is an abundant source of MSCs 5 ; its frozen form ensures both sustainability and easy accessibility of cells without necessitating invasive procurement methods like blood PBMCs 6 ; MSCs from umbilical cord tissue exhibit a higher proliferation rate, potentially increasing the efficiency of reprogramming processes 7 . Furthermore, given that iPSC reprogramming efficiency is much higher when using young cells, umbilical cords represent a superior cell source compared to blood cells from older donors 8 .…”

Section: Introductionmentioning

confidence: 99%

Efficient Generation of Human Pluripotent Stem Cells from Frozen Cord Tissue via Chemical Reprogramming

Nansubuga,

Mahnke,

et al. 2024

Preprint

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Chemical reprogramming presents an innovative approach for generating induced pluripotent stem cells (iPSCs), bypassing the genetic instability and safe concern associated with viral vector approach. We describe a novel, efficient chemical method for reprogramming human umbilical cord tissue-derived mesenchymal stem cells (MSCs) into induced pluripotent stem cells (iPSCs). Compared to previous sources like adipose tissue and skin, frozen umbilical cord tissue offers an abundant, non-invasive, long-term storable, and ethically sound cell source. Our findings not only showcase the feasibility and safety of utilizing chemical reprogramming on cells from frozen umbilical cords but also underscore its potential in regenerative medicine, especially for developing safer and more effective therapies for cardiovascular diseases.

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Comparative analysis of mesenchymal stem/stromal cells derived from human induced pluripotent stem cells and the cognate umbilical cord mesenchymal stem/stromal cells

Cited by 7 publications

References 58 publications

Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

Strategies in product engineering of mesenchymal stem cell-derived exosomes: unveiling the mechanisms underpinning the promotive effects of mesenchymal stem cell-derived exosomes

Efficient Generation of Human Pluripotent Stem Cells from Frozen Cord Tissue via Chemical Reprogramming

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