The environmental change in Northern Sub-Saharan Africa (NSSA) remains a challenge in relation with hydro-climatic variations and the low adaptation capacity of the region. The present study investigates the vegetation cover (NDVI) change associated with variations in hydro-climatic indicators over the period 1982–2015. The conventional statistical techniques such as the linear and multiple regressions, Mann-Kendall test, Sen’slope and the Pearson’s correlation were employed. The vegetation cover based on vegetation (NDVI) and hydro-climatic data were used. Trends in vegetation cover and hydro-climatic variables had monotonically increased except for the soil moisture that had monotonically decreased in the region. The proportion of significant positive (negative) changes were 46.78% (8.10%), 38.13% (0.34%), 52.12% (0.10%), 82.86% (0.00%) and 10.54% (38.27%) for NDVI, precipitation, potential evapotranspiration, temperature and soil moisture, respectively. The low vegetation dominated the NSSA region with a proportion of about 32% of the total area coverage. The vegetation classes including low coverage, very high coverage, and extreme high coverage exhibited increasing trends. Meanwhile, moderate coverage and high coverage exhibited decreasing trends. The area-averaged precipitation and temperature were positively correlated with the NDVI; however, the area-averaged soil moisture showed negative association with NDVI. Except the precipitation and Significant positive (negative) correlations of NDVI with the precipitation, temperature and soil moisture at the 5% level occupied 1.67% (11.59%), 3.37%(26.19%) and 10.24% (6.75%), respectively. However, the combine effects of hydro-climatic variables are better for the monitoring of vegetation cover. This confirms that the vegetation cover is influenced by many factors.