Comparative Analysis of Immunophenotypic Abnormalities in Cellular Immunity of Uremic Patients Undergoing Either Hemodialysis or Continuous Ambulatory Peritoneal Dialysis

Griveas, Ioannis; Visvardis, G.; Fleva, Alexandra; Papadopoulou, Dorothea; Mitsopoulos, E.; Kyriklidou, Parthena; Manou, Eleni; Ginikopoulou, Evdoxia; Meimaridou, D.; Paulitou, Aikaterini; Sakellariou, G

doi:10.1081/jdi-200056620

Cited by 18 publications

(19 citation statements)

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“…Comparative analysis of lymphocyte subsets concluded to a significant decrease in B and to a lesser extend NK and CD3 ϩ CD8 ϩ lymphocytes abso- lute numbers before graft in reference to healthy individuals, which may correlate with increased systemic inflammation and lowered immune responsiveness to infectious challenge often reported in hemodialyzed patients (21,22).…”

Section: Discussionmentioning

confidence: 97%

Tacrolimus/Mycophenolate Mofetil Improved Natural Killer Lymphocyte Reconstitution One Year After Kidney Transplant by Reference to Cyclosporine/Azathioprine

Vacher-Coponat

Brunet²,

Moal³

et al. 2006

Transplantation

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Section: Discussionmentioning

confidence: 97%

Tacrolimus/Mycophenolate Mofetil Improved Natural Killer Lymphocyte Reconstitution One Year After Kidney Transplant by Reference to Cyclosporine/Azathioprine

Vacher-Coponat

Brunet²,

Moal³

et al. 2006

Transplantation

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“…Up to two-thirds of dialysis patients are characterized by a malnutrition-inflammation syndrome [21], and many display disturbances in both innate and adaptive immunity [22-32]. This raises the intriguing hypothesis that Vitamin D deficiency could contribute to the inflammation and immune abnormalities found in this patient population, making it imperative that we understand the etiology of this problem and pursue solutions.…”

Section: Discussionmentioning

confidence: 99%

Low Dietary Intake of Vitamin D and Vitamin D Deficiency in Hemodialysis Patients

et al. 2014

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Background The purpose of this study was to test the hypothesis that decreased dietary intake of Vitamin D contributes to Vitamin D deficiency in end-stage renal disease (ESRD) patients on hemodialysis (HD). Methods We performed a cross-sectional study of 58 hemodialysis outpatients from two Mount Sinai Medical Center (MSMC)-affiliated outpatient HD units in New York City and 648 outpatients at MSMC with CKD stages I-IV. Serum 25(OH)D concentrations were measured from August 2010 to July of 2011 in recruited hemodialysis patients (n=58) and linked with results of dietary and lifestyle surveys. The Mount Sinai Data Warehouse (electronic medical record) was used to capture 25(OH) Vitamin D levels for outpatients with CKD stages I-IV who had Vitamin D testing during the same time period. Results The prevalence of Vitamin D insufficiency/deficiency in the HD cohort was 96.6%. Mean (SD) and median (IQR) 25(OH)D concentrations were 15.65 (6.82) and 13.55 (10.15) ng/mL, respectively. Dietary surveys showed a median weekly Vitamin D intake of 1044 IU (IQR=808, vs. a recommended weekly allowance of 4200 IU) and specific avoidance of foods containing both Vitamin D and phosphorus. In contrast, mean and median 25(OH)D concentrations in patients with CKD stages I-IV were 25.66 (13.44) and 23.60 (15.48) ng/mL (p<0.001 vs. HD patients). Conclusions Vitamin D deficiency is more prevalent in HD patients than in pre-dialysis patients with CKD and is associated with decreased dietary intake of Vitamin D. Dialysis restrictions imposed to reduce dietary phosphorus intake likely contributes to the development of hypovitaminosis D in ESRD patients.

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“…Lymphopenia and signs of T cell activation have been reported in a lot of the studies [16,17]. In-depth analysis of T cell subsets showed that lymphopenia is particularly prominent in the naïve T cell subset which showed a progressive decline in numbers as the stage of chronic kidney disease increased [2,18].…”

Section: Discussionmentioning

confidence: 99%

Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients

et al. 2012

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BackgroundEnd-stage renal disease (ESRD) patients treated with renal replacement therapy (RRT) have premature immunologically aged T cells which may underlie uremia-associated immune dysfunction. The aim of this study was to investigate whether uremia was able to induce premature ageing of the T cell compartment. For this purpose, we examined the degree of premature immunological T cell ageing by examining the T cell differentiation status, thymic output via T cell receptor excision circle (TREC) content and proliferative history via relative telomere length in ESRD patients not on RRT.ResultsCompared to healthy controls, these patients already had a lower TREC content and an increased T cell differentiation accompanied by shorter telomeres. RRT was able to enhance CD8+ T cell differentiation and to reduce CD8+ T cell telomere length in young dialysis patients. An increased differentiation status of memory CD4+ T cells was also noted in young dialysis patients.ConclusionBased on these results we can conclude that uremia already causes premature immunological ageing of the T cell system and RRT further increases immunological ageing of the CD8+ T cell compartment in particular in young ESRD patients.

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Comparative Analysis of Immunophenotypic Abnormalities in Cellular Immunity of Uremic Patients Undergoing Either Hemodialysis or Continuous Ambulatory Peritoneal Dialysis

Cited by 18 publications

References 0 publications

Tacrolimus/Mycophenolate Mofetil Improved Natural Killer Lymphocyte Reconstitution One Year After Kidney Transplant by Reference to Cyclosporine/Azathioprine

Tacrolimus/Mycophenolate Mofetil Improved Natural Killer Lymphocyte Reconstitution One Year After Kidney Transplant by Reference to Cyclosporine/Azathioprine

Low Dietary Intake of Vitamin D and Vitamin D Deficiency in Hemodialysis Patients

Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients

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