Comparative Analysis of Human Hepatic Lesions in Dengue, Yellow Fever, and Chikungunya: Revisiting Histopathological Changes in the Light of Modern Knowledge of Cell Pathology

Ribeiro, Yasmin Pacheco; Falcão, Luiz Fábio Magno; Smith, Vanessa Cavaleiro; Sousa, Jorge Rodrigues de; Pagliari, Carla; Franco, Edna Cristina Santos; Cruz, Ana Cecília Ribeiro; Chiang, Jannifer Oliveira; Martins, Lívia Carício; Nunes, Juliana Abreu Lima; Vilacoert, Fellipe Souza da Silva; Santos, Laís Carneiro dos; Furlaneto, Matheus Perini; Fuzii, Hellen Thaís; Filho, Marcos Virgilio Bertonsin; Costa, Luccas Delgado da; Duarte, Maria Irma Seixas; Furlaneto, Ismari Perini; Filho, Arnaldo Jorge Martins; Aarão, Tinara Leila de Souza; Vasconcelos, Pedro Fernando da Costa; Quaresma, Juarez Antônio Simões

doi:10.3390/pathogens12050680

Cited by 2 publications

(1 citation statement)

References 125 publications

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“…Emergent viruses may involve urbanization - in which humans have become the amplification hosts - and peridomestic mosquitoes (mainly Aedes aegypti) mediate human-to-human transmission (dengue, yellow fever, chikungunya and Zika viruses) ( 147 , 148 ). Secondary amplification, for example, has occurred in outbreaks of Japanese encephalitis, Venezuelan equine encephalitis, and Rift Valley fever viruses ( 149 , 150 ).…”

Section: Virus Reservoirs In Mammals and Birdsmentioning

confidence: 99%

Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents

Pereira,

Diniz,

da Costa

et al. 2023

Front. Immunol.

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Normally, the host immunological response to viral infection is coordinated to restore homeostasis and protect the individual from possible tissue damage. The two major approaches are adopted by the host to deal with the pathogen: resistance or tolerance. The nature of the responses often differs between species and between individuals of the same species. Resistance includes innate and adaptive immune responses to control virus replication. Disease tolerance relies on the immune response allowing the coexistence of infections in the host with minimal or no clinical signs, while maintaining sufficient viral replication for transmission. Here, we compared the virome of bats, rodents and migratory birds and the molecular mechanisms underlying symptomatic and asymptomatic disease progression. We also explore the influence of the host physiology and environmental influences on RNA virus expression and how it impacts on the whole brain transcriptome of seemingly healthy semipalmated sandpiper (Calidris pusilla) and spotted sandpiper (Actitis macularius). Three time points throughout the year were selected to understand the importance of longitudinal surveys in the characterization of the virome. We finally revisited evidence that upstream and downstream regulation of the inflammatory response is, respectively, associated with resistance and tolerance to viral infections.

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Section: Virus Reservoirs In Mammals and Birdsmentioning

confidence: 99%

Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents

Pereira,

Diniz,

da Costa

et al. 2023

Front. Immunol.

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View full text Add to dashboard Cite

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Effect of dengue infection on liver profile and hematological parameters

Hunais,

Shiffana,

Udayangani

2024

IJMLST

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Dengue fever is endemic in Sri Lanka. Liver damage is common in dengue fever. Understanding the pattern change of the liver profile and haematological parameters is crucial for managing dengue patients and minimising liver damage. The purpose of this study was to determine the pattern change in liver profile and the haematological parameters of dengue patients. Sixty apparently healthy volunteers and 169 acute dengue patients aged 20 or older had their blood samples examined. Liver enzymes, albumin, protein, bilirubin, white blood cell count, platelet count, haematocrit, and haemoglobin were measured. There was an increase in aspartate aminotransferase (105.6 IU/L), alanine aminotransferase (82.6 IU/L), and gamma-glutamyl transferase (68.9 IU/L), which were 3.4, 3.9, and 3.2-fold higher, respectively, than those of the control group, suggesting liver injury. Eighty-four percent of patients had raised levels of aspartate aminotransferase, and 74% of patients had elevated levels of alanine aminotransferase, indicating the prominence of aspartate aminotransferase over alanine aminotransferase. The presence of a positive correlation between the levels of aspartate aminotransferase and alanine aminotransferase indicates that the elevation of enzymes is primarily due to a single cause, liver injury. White blood cells and platelet counts were significantly lower. Platelet count demonstrated a negative correlation with both haematocrit and haemoglobin in dengue patients. In conclusion, aspartate aminotransferase was identified as the most significant marker of dengue-associated liver injury, followed by alanine aminotransferase. Low platelet and white blood cell counts were the major unfavourable changes in dengue patients' haematological characteristics.

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Comparative Analysis of Human Hepatic Lesions in Dengue, Yellow Fever, and Chikungunya: Revisiting Histopathological Changes in the Light of Modern Knowledge of Cell Pathology

Cited by 2 publications

References 125 publications

Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents

Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents

Effect of dengue infection on liver profile and hematological parameters

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