Comparative Analysis of Free and Glycoconjugates Oligosaccharide Content in Milk from Different Species

Zhong, Peiyun; Yang, Yuerong; Han, Tianjiao; Huang, Wenqi; Liu, Yuxia; Gong, Guiping; Huang, Linjuan; Lu, Yu; Wang, Zhongfu

doi:10.1021/acs.jafc.3c06317

Cited by 3 publications

(1 citation statement)

References 35 publications

(65 reference statements)

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“…Oligosaccharides (GOS) and sugar conjugates are the most important bioactive components of milk and significantly affect gut health. Relative to human milk, the concentration of GOS in bovine milk is notably low . Milk GOS exhibit a range of biological activities, functioning as prebiotics, anti-infective agents, and immune system regulators .…”

Section: The Guardian Effect Of Milk Ingredients On the Gut Barriermentioning

confidence: 99%

Milk: A Natural Guardian for the Gut Barrier

Wang,

Gong,

Farid

et al. 2024

J. Agric. Food Chem.

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The gut barrier plays an important role in health maintenance by preventing the invasion of dietary pathogens and toxins. Disruption of the gut barrier can cause severe intestinal inflammation. As a natural source, milk is enriched with many active constituents that contribute to numerous beneficial functions, including immune regulation. These components collectively serve as a shield for the gut barrier, protecting against various threats such as biological, chemical, mechanical, and immunological threats. This comprehensive review delves into the active ingredients in milk, encompassing casein, α-lactalbumin, β-lactoglobulin, lactoferrin, the milk fat globular membrane, lactose, transforming growth factor, and glycopeptides. The primary focus is to elucidate their impact on the integrity and function of the gut barrier. Furthermore, the implications of different processing methods of dairy products on the gut barrier protection are discussed. In conclusion, this study aimed to underscore the vital role of milk and dairy products in sustaining gut barrier health, potentially contributing to broader perspectives in nutritional sciences and public health.

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Section: The Guardian Effect Of Milk Ingredients On the Gut Barriermentioning

confidence: 99%

Milk: A Natural Guardian for the Gut Barrier

Wang,

Gong,

Farid

et al. 2024

J. Agric. Food Chem.

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Unlocking the mysteries of milk oligosaccharides: Structure, metabolism, and function

Yao,

Gao,

Zheng

et al. 2024

Carbohydrate Polymers

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Preparatory work for the safety evaluation by EFSA of Human‐identical Milk Oligosaccharides as Novel Foods

Malih,

Konieczna,

Fernandez

et al. 2024

EFSA Supporting Publications

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Background and aims This report describes a scoping literature review as preparatory work for the safety evaluation by EFSA of Human‐identical Milk Oligosaccharides (HiMOs) as Novel Foods (NFs). The main objective was to gather information on the concentrations of Human Milk Oligosaccharides (HMOs) in human milk, both individual and total, and the combinations/mixtures of HiMOs/HMOs in commercially available products or those reported in the literature. Methods A scoping literature review was conducted, including a search strategy implemented in biomedical (PubMed) and multidisciplinary (Web of Science) databases from 2013 to March 2024, supplemented by an ad hoc search for primary studies included in two key recent systematic reviews and grey literature searches on relevant food business operators' websites. Both primary and secondary studies were selected to determine the individual concentrations of target HMOs, the total concentration of HMOs and relevant HMO fractions, and the combinations/mixtures of HiMOs/HMOs. Only studies with full text published in English or Spanish were eligible, excluding patents, editorials, conference abstracts, books, and dissertations. Results The structured searches yielded 2,851 unique references, with 218 selected for full‐text evaluation and 36 additional unique references from the key systematic reviews. Ultimately, 171 publications were included in the review. Fourteen companies related to HiMOs were identified through grey literature. In most publications, concentration data for multiple groups of donors (e.g., based on factors like secretor status or lactation period) were reported. By groups of donors, the mean total concentration of HMOs in milk (excluding colostrum) was 6,740 mg/L, whereas the mean by publication was 5,341 mg/L. By publication, the mean concentrations of individual HMOs (mg/L, excluding colostrum) were: LNnT 288, LNT 971, 2'‐FL 1,468, 3‐FL 800, DFL 232, 3'‐SL 212, 6'‐SL 365, LNFP I 738, and LNT/LNnT 611. By groups of donors, the mean concentrations (mg/L, excluding colostrum) were: LNnT 382, LNT 1064.1, 2'‐FL 1685, 3‐FL 907, DFL 303, 3'‐SL 225, 6'‐SL 435, LNFP I 773, and LNT/LNnT 882. By publication, the mean concentration (mg/L) of groups of HMOs mean concentrations (excluding colostrum) was: 4,577 for total neutral; 851 for total acidic; 4,635 for total acidic fucosylated; 1,631 for α‐1‐3/4‐fucosylated; 3,304 for α‐1‐2‐fucosylated; 1,601 for non‐fucosylated; 1,505 for total sialyllated; 2,293 for acidic sialyllated. By group of donors, the mean concentration (mg/L) of groups of HMOs mean concentrations (excluding colostrum) was: 3,942 for total neutral; 1,032 for total acidic; 6,477 for total acidic fucosylated; 1,650 for α‐1‐3/4‐fucosylated; 3,748 for α‐1‐2‐fucosylated; 2,026 for non‐fucosylated; 1,957 for total sialyllated; 2,293 for acidic sialyllated. The most frequent combinations of HMOs/HiMOs were LNnT + 2'‐FL (24 products, 32%) and 2'‐FL + 3'‐SL (12 products, 16%). Conclusions The findings of this review will support EFSA in the safety evaluation of HiMOs as NFs, in accordance with the EC mandate (M‐2023‐00157).

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Comparative Analysis of Free and Glycoconjugates Oligosaccharide Content in Milk from Different Species

Cited by 3 publications

References 35 publications

Milk: A Natural Guardian for the Gut Barrier

Milk: A Natural Guardian for the Gut Barrier

Unlocking the mysteries of milk oligosaccharides: Structure, metabolism, and function

Preparatory work for the safety evaluation by EFSA of Human‐identical Milk Oligosaccharides as Novel Foods

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