Comparative analysis of essential oil composition of Iranian and Indian &lt;em&gt;Nigella sativa&lt;/em&gt; L. extracted using supercritical fluid extraction and solvent extraction

Ghahramanloo, Kourosh Hasanzadeh; Kamalıdehghan, Behnam; Javar, Hamid Akbari; Widodo, Riyanto Teguh; Majidzadeh, Keivan; Noordin, Mohamed Ibrahim

doi:10.2147/dddt.s87251

Cited by 43 publications

(24 citation statements)

References 21 publications

(26 reference statements)

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“…The results of the present study showed that NSO is an important source of bioactive compounds, especially p-cymene, TQ and α-thujene. The percentages of the identified compound are consistent with other reported results [ 30 , 31 ].…”

Section: Discussionsupporting

confidence: 93%

Nigella Sativa’s Anti-Inflammatory and Antioxidative Effects in Experimental Inflammation

et al. 2020

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Nigella sativa (NS) has been used for centuries in various inflammatory conditions because of its anti-inflammatory and antioxidant activities. The study aimed to evaluate the anti-inflammatory, antinociceptive and antioxidant activity of Nigella sativa oil (NSO) in two models of acute (carrageenan-induced) and sub-acute inflammation (complete Freund’s adjuvant induced) in rats. Materials and Methods: NSO was administered orally 1, 2 and 4 mL/kg in the acute phase. For subacute phase, NSO was administered 4 mL/kg, 7 days before or after inflammation induction, or in association with diclofenac 5 mg/kg. Results: The gas chromatography coupled with mass spectroscopy (GC-MS) analysis showed that NSO is an important source of bioactive compounds, especially p-cymene and thymoquinone. In the acute phase, 1.5 h after administration, NSO (2 and 4 mL/kg) determined an anti-inflammatory effect comparable with that of diclofenac. In the sub-acute administration, NSO had no anti-inflammatory effect. The analgesic effect of NSO was observed only in the sub-acute inflammation in the analgesy-meter test. NSO as treatment proved its antioxidant effect through the reduction of malondialdehyde (MDA) and oxidized glutathione (GSSG), and increases in hydrogen donor capacity (DH) compared to the control group, but the effect was not as intense as that of diclofenac. Conclusion: The present study has proven inconstant anti-inflammatory, analgesic and antioxidative properties of NSO.

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Section: Discussionsupporting

confidence: 93%

Nigella Sativa’s Anti-Inflammatory and Antioxidative Effects in Experimental Inflammation

et al. 2020

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“…The N. sativa seed contain 26-34% fixed oil of which the major fatty acids are linoleic acid (64.6%) and palmitic acid (20.4%). The seed oil is comprised of 0.4%–2.5% essential oil [9, 10]. Amongst different active constituents reported so far, thymoquinone found as major component of the essential oil is the most bioactive compound and exhibits wide ranging therapeutic benefits [11].…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

Yimer

Tuem

Karim

et al. 2019

Evidence-Based Complementary and Alternative Medicine

307

228

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The seed of Nigella sativa (N. sativa) has been used in different civilization around the world for centuries to treat various animal and human ailments. So far, numerous studies demonstrated the seed of Nigella sativa and its main active constituent, thymoquinone, to be medicinally very effective against various illnesses including different chronic illness: neurological and mental illness, cardiovascular disorders, cancer, diabetes, inflammatory conditions, and infertility as well as various infectious diseases due to bacterial, fungal, parasitic, and viral infections. In spite of limited studies conducted so far, the promising efficacy of N. sativa against HIV/AIDS can be explored as an alternative option for the treatment of this pandemic disease after substantiating its full therapeutic efficacy. Moreover, the strong antioxidant property of this valued seed has recently gained increasing attention with regard to its potential role as dietary supplement with minimal side effects. Besides, when combined with different conventional chemotherapeutic agents, it synergizes their effects resulting in reducing the dosage of concomitantly used drugs with optimized efficacy and least and/or no toxicity. A number of pharmaceutical and biological properties have been ascribed to seeds of N. sativa. The present review focuses on the profile of high-value components along with traditional medicinal and biological principles of N. sativa seed and its oil so as to explore functional food and nutraceutical potential of this valued herb.

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“…The composition of terpenes, characteristic of such an essential oil, does not correspond to the qualitative composition (and quantitative content) of terpenes, which have been converted to fatty oil in the process of its production by pressing. In the extraction of fatty oil, a large part of the terpenes are extracted together with triacylglycerides, but their composition and content also significantly vary and very much depends on the properties of the extractant used [37]. In turn, the variability of the content of essential oil in the seeds indicates the unreliability and unacceptability of the indicator "content of essential oil" for the purpose of standardization of black cumin.…”

Section: Advances In Engineering Research Volume 151mentioning

confidence: 99%

Recycling and Standardization Aspects of Nigella sativa in the Food Industr

Егорова¹,

Резніченко²,

Ermolaeva³

2018

International Scientific and Practical Conference "AgroSMART - Smart Solutions for Agriculture" (AgroSMART 2018)

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Black cumin seeds and products of its processingbutter and semi-skimmed flour-have high nutritional and market value. At the same time, there are no unified state or international requirements and standard methodologies for confirming the authenticity and quality of butter, flour and food products that include them. The aim of this work is to analyze data on the composition of black cumin oil and flour and justify the list of regulated indicators and methods for confirming their authenticity and quality. The paper analyzes data on the chemical composition of black cumin oil. The limits of the content of the most physiologically important fatty acids-Linoleic, Linolenic and Eicosadienoic-are recommended for standardization and confirmation of the authenticity of fatty oil; standardization method is recommended. Data on the content of terpenes in the essential black cumin oil is summarized, the variability of the composition and content of the prevailing terpenes is shown. According to the results of studies of black cumin seed flour, a list of regulated organoleptic and physico-chemical indicators of the quality of this food raw material has been proposed.

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Comparative analysis of essential oil composition of Iranian and Indian <em>Nigella sativa</em> L. extracted using supercritical fluid extraction and solvent extraction

Cited by 43 publications

References 21 publications

Nigella Sativa’s Anti-Inflammatory and Antioxidative Effects in Experimental Inflammation

Nigella Sativa’s Anti-Inflammatory and Antioxidative Effects in Experimental Inflammation

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

Recycling and Standardization Aspects of Nigella sativa in the Food Industr

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