Comparative Analysis of Electrochemiluminescence Assay and Chemiluminescent Microparticle Immunoassay for the Screening of Hepatitis C

Wadood, Maeesa; Usman, Muhammad

doi:10.1007/s12288-018-0968-3

Cited by 7 publications

(5 citation statements)

References 27 publications

(39 reference statements)

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“…The first strength of this study was the use of a large database covering a wide geographic location of the Taiwanese population. Second, the study used a highly sensitive method for the diagnosis of HCV and HBV cases, ECLIA, which has a sensitivity greater than 99% and a specificity of 100% [ 31 ]. This implies a high diagnostic accuracy for HBV and HCV infections.…”

Section: Discussionmentioning

confidence: 99%

The association between hepatic viral infections and cancers: a cross-sectional study in the Taiwan adult population

Maliko,

Su,

Kamiza

et al. 2024

Clin Exp Med

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Background Hepatitis B (HBV) and hepatitis C (HCV) viruses are diseases of global public health concern and are associated with liver cancer. Recent studies have revealed associations between hepatic viral infections and extrahepatic cancers. This study aimed to explore the associations between hepatitis B and C viruses and cancer at baseline in the Taiwan Biobank database while controlling for a wide range of confounding variables. Methods In a cross-sectional study of adults aged > 20 years, we compared the distribution of demographic factors, lifestyle, and comorbidities between viral and nonviral hepatic groups using the chi-square test. Univariate and multivariate logistic regressions were performed to observe the associations between hepatitis B and C viral infections and cancers by estimating the odds ratio (OR) and 95% confidence interval (CI). Multivariate regression analysis was adjusted for sociodemographic factors, lifestyle, and comorbidities. Results From the database, 2955 participants were identified as having HCV infection, 15,305 as having HBV infection, and 140,108 as the nonviral group. HBV infection was associated with an increased likelihood of liver cancer (adjusted OR (aOR) = 6.60, 95% CI = 3.21–13.57, P < 0.001) and ovarian cancer (aOR = 4.63, 95% CI = 1.98–10.83, P = 0.001). HCV infection was observed to increase the likelihood of liver cancer (aOR = 4.90, 95% CI = 1.37–17.53, P = 0.015), ovarian cancer (aOR = 8.50, 95% CI = 1.78–40.69, P = 0.007), and kidney cancer (aOR = 12.89, 95% CI = 2.41–69.01, P = 0.003). Conclusion Our findings suggest that hepatic viral infections are associated with intra- and extrahepatic cancers. However, being cross-sectional, causal inferences cannot be made. A recall-by-genotype study is recommended to further investigate the causality of these associations.

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Section: Discussionmentioning

confidence: 99%

The association between hepatic viral infections and cancers: a cross-sectional study in the Taiwan adult population

Maliko,

Su,

Kamiza

et al. 2024

Clin Exp Med

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“…The rst strength of this study was the use of a large database covering a wide geographic location of the Taiwanese population. Second, the study used a highly sensitive method for the diagnosis of HCV and HBV cases, ECLIA, which has a sensitivity greater than 99% and a speci city of 100% 31 . This implies a high diagnostic accuracy for HBV and HCV infections.…”

Section: Discussionmentioning

confidence: 99%

The association between hepatic viral infections and cancers: A cross-sectional study in the Taiwan adult population

Maliko,

Yeh

2023

ISEE Conference Abstracts

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BackgroundHepatitis B (HBV) and hepatitis C (HCV) viruses are diseases of global public health concern and are associated with liver cancer. Recent studies have revealed associations between hepatic viral infections and extrahepatic cancers. This study aimed to explore the associations between hepatitis B and C viruses and cancer at baseline in the Taiwan Biobank database while controlling for a wide range of confounding variables. MethodsIn a cross-sectional study of adults aged > 20 years, we compared the distribution of demographic factors, lifestyle, and comorbidities between viral and nonviral hepatic groups using the chi-square test. Univariate and multivariate logistic regressions were performed to observe the associations between hepatitis B and C viral infections and cancers by estimating the odds ratio (OR) and 95% con dence interval (CI). Multivariate regression analysis was adjusted for sociodemographic factors, lifestyle, and comorbidities. ResultsFrom the database, 2,955 participants were identi ed as having HCV infection, 15,305 as having HBV infection, and 140,108 as the nonviral group. HBV infection was associated with an increased likelihood of liver cancer (adjusted OR (aOR) = 7.09, 95% CI = 3.48-14.44, P < 0.001) and ovarian cancer (aOR = 3.86, 95% CI = 1.68-8.88, P = 0.002). HCV infection was observed to increase the likelihood of liver cancer (aOR = 4.69, 95% CI = 1.34-16.36, P = 0.015), ovarian cancer (aOR = 5.19, 95% CI = 1.17-22.97, P = 0.030), and kidney cancer (aOR = 10.27, 95% CI = 2.06-52.25, P = 0.005). ConclusionOur ndings suggest that hepatic viral infections are associated with intra-and extrahepatic cancers. However, being cross-sectional, causal inferences cannot be made. A recall-by-genotype study is recommended to further investigate the causality of these associations.

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“…A similar finding is observed in other studies. [15][16][17] A positive HCV Ab result may be seen in patients with current or resolved HCV infection. However, false HCV Ab positive results may be found if the reliability of assay is compromised.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Hepatitis C Antibody Assays and Evaluation of Agreement Between Hepatitis C Antigen and PCR Results

Iqbal

Baig

Naseem

et al. 2022

J Ayub Med Coll Abbottabad

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Background: Hepatitis C is associated with a wide range of health repercussions. Pakistan is one of the highly prevalent countries of Hepatitis C Virus (HCV) infection. The availability of cost-effective, robust, and reliable screening and diagnostic tests for hepatitis C is important to address the disease burden. Standardization of screening and diagnostic assays in clinical laboratories is crucial for achieving big goals. Objectives of this study are to correlate the results of two different HCV antibody (HCV Ab) assays and to examine the correlation of HCV core antigen (HCV c Ag) results with HCV PCR for HCV infection diagnosis. Methods: This descriptive cross-sectional study was carried out from November to December 2020 at Dow University of Health Sciences. Total number of 40 HCV Ab samples were analysed by both chemiluminescence (CMIA) and electrochemiluminescence (ECLIA) immunoassays. Tests for HCV RNA PCR and HCV c Ag were performed on all samples. Results of screening and diagnostic assays were correlated and agreements were examined. Statistical analysis for agreement was carried out by using R software version 3.6.3 through AC1 Gwetz Statistic. The study was approved by the institutional ethical review committee. Results: An agreement of 0.73 and 0.95 was found between two different HCV Ab immunoassays and HCV c Ag and HCV PCR, respectively. Conclusion: We found a good correlation between CMIA and ECLIA for HCV Ab. An excellent correlation was found between HCV c Ag and HCV PCR. Based on our study findings, HCV c Ag is a candidate test for the diagnosis of active HCV infection.

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Comparative Analysis of Electrochemiluminescence Assay and Chemiluminescent Microparticle Immunoassay for the Screening of Hepatitis C

Cited by 7 publications

References 27 publications

The association between hepatic viral infections and cancers: a cross-sectional study in the Taiwan adult population

The association between hepatic viral infections and cancers: a cross-sectional study in the Taiwan adult population

The association between hepatic viral infections and cancers: A cross-sectional study in the Taiwan adult population

Comparison of Hepatitis C Antibody Assays and Evaluation of Agreement Between Hepatitis C Antigen and PCR Results

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