Comparative Analysis of Effects of Various Types of Double-Stranded RNA on Cultured Human Laryngeal Cancer Cells

Abstract

We compared the effects of Na+ and Ca2+ double-stranded RNA on cultured human laryngeal cancer cells by cytomorphometry and cytophotometry. Both agents inhibited proliferation and other cell functions, but to a different extent: Ca2+ double-stranded RNA was more active than Na+ double-stranded RNA.

Comparative Multiparametric Analysis of HeLa and RD Cell Culture Reactions to Solcoseryl

“…The nucleolar/nuclear ratio and the mean number of nucleoli in the nuclei virtually did not change ( Table 2). The nucleoli (1)(2)(3)(4) were detected in all cellular nuclei in both cultures, each nucleus containing 2 nucleoli, on average ( Table 2). The presence and number of nucleoli in the nuclei is an important criterion characterizing the physiological status of the cells.…”

“…A. Magakian Continuous cell cultures are convenient models for evaluation of the effects of active compounds on cells and cell populations. We studied the reaction of Hep-2 cell culture to addition of Na + -and Ca 2+ -doublestranded RNA to the medium [3] and compared the reactions of cultured cells [2]. The presence of these bioactive substances in culture medium suppressed proliferation and other functions of cells; Ca 2+ -doublestranded RNA exhibited higher activity.…”