Comparative analysis of differentiation and behavior of human neural and mesenchymal stem cells In Vitro and In Vivo

Александрова, М. А.; Сухих, Г. Т.; Chailakhyan, R. K.; Podgornyi, O. V.; Marei, M. V.; Полтавцева, Р. А.; Gerasimov, Yu. V.

doi:10.1007/s10517-006-0116-1

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…However, little is known about the neural pathway of MSC differentiation. A comparative study was performed to evaluate the differentiation of human NSC and MSC in the tissue culture and after intracerebral transplantation to rats [1]. NSC differentiate into all types of neural cells, migrate, and have reciprocal relationships with the recipient brain.…”

Section: Resultsmentioning

confidence: 99%

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Morphofunctional Study of the Therapeutic Efficacy of Human Mesenchymal and Neural Stem Cells in Rats with Diffuse Brain Injury

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Roshal²,

Сухих

et al. 2009

Bull Exp Biol Med

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We studied the effect of transplantation of human stem cells from various tissues on reparative processes in the brain of rats with closed craniocerebral injury. Combined treatment with standard drugs and systemic administration of xenogeneic stem cells had a neuroprotective effect. The morphology of neurons rapidly returned to normal after administration of fetal neural stem cells. Fetal mesenchymal stem cells produced a prolonged effect on proliferative activity of progenitor cells in the subventricular zone of neurogenesis. Adult mesenchymal stem cells had a strong effect on recovery of the vascular bed in ischemic regions.

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Section: Resultsmentioning

confidence: 99%

“…The primary culture of adult bone marrow MSC and human fetal MSC and NSC (9-10 weeks gestation, medical abortion product) were obtained as described elsewhere [1,5]. Experiments were performed on male Wistar rats weighing 140-160 g. CCT was produced by a 50-g weight, which fell on the parietal region of the head from a height of 110 cm [6].…”

Section: Methodsmentioning

confidence: 99%

Morphofunctional Study of the Therapeutic Efficacy of Human Mesenchymal and Neural Stem Cells in Rats with Diffuse Brain Injury

Цыб

Roshal²,

Сухих

et al. 2009

Bull Exp Biol Med

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“…The primary culture of adult bone marrow MSC and human FMSC and FNSC (9-10 weeks gestation, medical abortion product) were obtained as described elsewhere [1,10].…”

Section: Methodsmentioning

confidence: 99%

“…Cognitive functions of control rats and BI animals were estimated from the acquisition of the conditioned avoidance response (CAR) in the shuttle box [1,3]. Before trauma, the animals were selected by learning capacity and divided into comparable groups.…”

Section: Methodsmentioning

confidence: 99%

Effect of Cell Therapy on Recovery of Cognitive Functions in Rats during the Delayed Period after Brain Injury

Roshal¹,

Tzyb

Павлова

et al. 2009

Bull Exp Biol Med

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We studied the effect of systemic transplantation of human stem cells from various tissues on cognitive functions of the brain in rats during the delayed period after experimental brain injury. Stem cells were shown to increase the efficacy of medical treatment with metabolic and symptomatic drugs for recovery of cognitive functions. They accelerated the formation of the conditioned defense response. Fetal neural stem cells had a stronger effect on some parameters of cognitive function 2 months after brain injury. The efficacy of bone marrow mesenchymal stem cells from adult humans or fetuses was higher 3 months after brain injury.

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Effect of Transplants of Retinal Pigment Epithelial Cells from Adult Human Eye on Degenerative Processes in the Brain of Rats with Experimental Acute Hypoxia

et al. 2014

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Stimulation of cell regeneration in the brain and eye retina in various degenerative processes is a pressing problem in neurobiology. A promising approach is transplantation of somatic cells reprogrammed towards neural lineage. We studied the effect of transplantation of retinal pigment epithelial cells from adult human eye transdifferentiated in culture on degenerative processes in the brain of rats subjected to acute hypoxia. Immunohistochemical and molecular genetic analysis suggests that retinal pigment epithelial cells transdifferentiate in vitro and express markers of low-differentiated neural cells. The cells transplanted into rat brain survive for at least 20 days. During this period, they stimulate compensatory and reparative processes that protected cortical neurons in the recipients from hypoxia-induced degeneration.

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Comparative analysis of differentiation and behavior of human neural and mesenchymal stem cells In Vitro and In Vivo

Cited by 7 publications

References 24 publications

Morphofunctional Study of the Therapeutic Efficacy of Human Mesenchymal and Neural Stem Cells in Rats with Diffuse Brain Injury

Morphofunctional Study of the Therapeutic Efficacy of Human Mesenchymal and Neural Stem Cells in Rats with Diffuse Brain Injury

Effect of Cell Therapy on Recovery of Cognitive Functions in Rats during the Delayed Period after Brain Injury

Effect of Transplants of Retinal Pigment Epithelial Cells from Adult Human Eye on Degenerative Processes in the Brain of Rats with Experimental Acute Hypoxia

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