Comparative Analysis of Clinical Factors Associated with Ocular Surface Squamous Neoplasia in HIV Infected and Non HIV Patients

Kabra, Ruchi; Khaitan, Isha A

doi:10.7860/jcdr/2015/13236.5932

Cited by 12 publications

(9 citation statements)

References 23 publications

(21 reference statements)

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“…There appears to be an important association between human immunodeficiency virus (HIV) seropositivity and OSSN [3,[12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Patients presenting with OSSN might therefore benefit from HIV testing.…”

Section: Introductionmentioning

confidence: 99%

A prospective study of the incidence, associations and outcomes of ocular surface squamous neoplasia in the United Kingdom

Kiire

Stewart

Srinivasan

et al. 2018

Eye

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Section: Introductionmentioning

confidence: 99%

A prospective study of the incidence, associations and outcomes of ocular surface squamous neoplasia in the United Kingdom

Kiire

Stewart

Srinivasan

et al. 2018

Eye

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“…A related study has been previously published by the authors from the centre on the comparison of clinical factors of OSSN in HIV-affected patients and in patients without HIV infection [18]. Feeder vessels and increased invasiveness were also seen in all HIV infected cases [18]. In a similar study by Makupa et al, an association between feeder vessel and HIV was also noted.…”

Section: Discussionmentioning

confidence: 61%

“…We found a larger number of lesions with a base greater than 5mm and with fornicial extension at the time of presentation, in HIV affected population. A related study has been previously published by the authors from the centre on the comparison of clinical factors of OSSN in HIV-affected patients and in patients without HIV infection [18]. Feeder vessels and increased invasiveness were also seen in all HIV infected cases [18].…”

Section: Discussionmentioning

confidence: 83%

Clinicopathological analysis of 55 cases of ocular surface squamous neoplasia

Kabra¹,

Morawala²,

Maheshwari³

2016

Trop J Ophthalmol Otolaryngol

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Introduction: The aim of this observational study is to review the presenting clinical features and histopathology of 55 cases of OSSN, at a tertiary care institute in Western India. Method: The study enrolled patients from the in-patient department. The workup included a detailed history with Slit-lamp examination, clinical photographs and histopathological analysis of tissue samples taken via incisional or en-block excisional biopsy. Results: The mean age of the patients was 38.2 years. 25.4% of patients were HIV reactive, with an average age of 26.8 years. The most common presenting complaints were redness, watering and foreign body sensation occurring in 59.9% of the cases. 29% patients were asymptomatic or presented with complaints of a whitish mass lesion. Morphologically, the commonest lesion was of the Leukoplakic variety (32.72% of cases). On histopathological analysis, 41.8% of cases showed intraepithelial carcinoma, with mild dysplasia in a majority of cases. Invasive carcinoma was seen in 58.18% of cases, with poorly differentiated cells in a majority of them. Conclusion: We conclude from the study that the affected population is younger in our region of the world, than in the West. HIV screening would help identify occult cases of HIV which present only with OSSN. Increased awareness of this disease among ophthalmologists would help ensure an early and definitive diagnosis.

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“…Solitary tumors can be nodular, noduloulcerative, gelatinous, leukoplakic, placoid, or papillary in morphology 61 ( Figure 1 ). Makupa et al noted higher incidence of leukoplakia and feeder vessels, 7 while Kabra et al mentioned large lesions with fornicial extension 62 at the time of presentation in HIV-infected patients.…”

Section: Clinical Featuresmentioning

confidence: 99%

Ocular surface squamous neoplasia in HIV-infected patients: current perspectives

Rathi¹,

Kapoor²,

Kaliki³

2018

HIV

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Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial tumors including dysplasia, carcinoma in situ, and invasive carcinoma. In this article, we discuss the current perspectives of OSSN associated with HIV infection, focusing mainly on the epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment of these tumors in patients with HIV. Upsurge in the incidence of OSSN with the HIV pandemic most severely affected sub-Saharan Africa, due to associated risk factors, such as human papilloma virus and solar ultraviolet exposure. OSSN has been reported as the first presenting sign of HIV/AIDS in 26%–86% cases, and seropositivity is noted in 38%–92% OSSN patients. Mean age at presentation of OSSN has dropped to the third to fourth decade in HIV-positive patients in developing countries. HIV-infected patients reveal large aggressive tumors, higher-grade malignancy, higher incidence of corneal, scleral, and orbital invasion, advanced-stage T4 tumors, higher need for extended enucleation/exenteration, and increased risk of tumor recurrence. Current management of OSSN in HIV-positive individuals is based on standard treatment guidelines described for OSSN in the general population, as there is little information available about various treatment modalities or their outcomes in patients with HIV. OSSN can occur at any time in the disease course of HIV/AIDS, and no significant trend has been discovered between CD4 count and grade of OSSN. Furthermore, the effect of highly active antiretroviral therapy on OSSN is controversial. The current recommendation is to conduct HIV screening in all cases presenting with OSSN to rule out undiagnosed HIV infection. Patient counseling is crucial, with emphasis on regular follow-up to address high recurrence rates and early presentation to an ophthalmologist for of any symptoms in the unaffected eye. Effective evidence-based interventions are needed to allow early diagnosis and treatment, as well as prevention of the disease.

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Comparative Analysis of Clinical Factors Associated with Ocular Surface Squamous Neoplasia in HIV Infected and Non HIV Patients

Cited by 12 publications

References 23 publications

A prospective study of the incidence, associations and outcomes of ocular surface squamous neoplasia in the United Kingdom

A prospective study of the incidence, associations and outcomes of ocular surface squamous neoplasia in the United Kingdom

Clinicopathological analysis of 55 cases of ocular surface squamous neoplasia

Ocular surface squamous neoplasia in HIV-infected patients: current perspectives

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