Comparative analysis of chlorambucil-induced DNA lesion formation and repair in a spectrum of different human cell systems

DNA Adducts in Cancer Chemotherapy

“…Another study quantified the two major DNA monoadducts, Ade- N 3 117 and Gua- N 7 119 (Figure ), and DNA interstrand cross-links (e.g., 121 ) in five human cell lines and peripheral blood mononuclear cells (PBMCs) after chlorambucil treatment. Significant differences were observed in the repair kinetics of DNA monoadducts as well as interstrand cross-links in cell systems with different origins and transformation statuses …”

“…Significant differences were observed in the repair kinetics of DNA monoadducts as well as interstrand cross-links in cell systems with different origins and transformation statuses. 199 High-dose melphalan, in combination with autologous stem cell transplantation, serves as the standard treatment for newly diagnosed multiple myeloma. However, this therapeutic approach can result in high-grade toxicities, including cardiotoxicity.…”

Chlorambucil-Bearing Hybrid Molecules in the Development of Potential Anticancer Agents

“…It was also approved to treat patients with indolent B-cell non-Hodgkin lymphoma [2,28]. Moreover, it is typically used to treat Hodgkin's disease, chronic lymphosarcoma, lymphocytic leukaemia, giant follicular lymphoma, and malignant lymphoma [28,29]. Although it is a potent drug to treat different cancer types, its anticancer activity is hindered by numerous drawbacks, such as a lack of specificity, drug resistance, toxicity, and a short half-life.…”

“…Although it is a potent drug to treat different cancer types, its anticancer activity is hindered by numerous drawbacks, such as a lack of specificity, drug resistance, toxicity, and a short half-life. Therefore, its modification is an attractive approach for developing effective anticancer drugs [19,[28][29][30].…”