Comparative Analysis of Biomechanical Performance of Available “Nerve Glues”

Isaacs, Jonathan; McDaniel, Candice; Owen, John R.; Wayne, Jennifer S.

doi:10.1016/j.jhsa.2008.02.009

Cited by 66 publications

(53 citation statements)

References 27 publications

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“…Previously, the only study [13] comparing EVICEL Fibrin Sealant (Human) and TISSEEL Fibrin Sealant was a biomechanical performance comparison regarding strength of repair following the utilization of the two products following the suture repair of experimentally transected nerves. Nerve sections treated with EVI-CEL Fibrin Sealant (Human), TISSEEL Fibrin Sealant, or DuraSeal polyethylene glycol sealant (Confluent Surgical, Inc., Waltham, Massachusetts, USA) demonstrated significantly greater resistance to gapping than the control group (no treatment; P < 0.01 for all comparisons); no differences were observed between active treatments.…”

Section: Evicel Fibrin Sealant (Human) (Johnson and Johnsonmentioning

confidence: 99%

A comparison of the mechanical, kinetic, and biochemical properties of fibrin clots formed with two different fibrin sealants

Hickerson

Nur²,

Meidler³

2011

Blood Coagulation &Amp; Fibrinolysis

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The objective of the present study was to compare the mechanical, kinetic, and biochemical properties of fibrin clots produced using EVICEL Fibrin Sealant (Human) and TISSEEL Fibrin Sealant. The stiffness/elasticity and strength of fibrin clots formed with EVICEL and TISSEEL were assessed using applied mechanical force and thromboelastography (TEG). The factor XIII content of the fibrin clots was also evaluated. Mean Young modulus and tensile strength of the fibrin clots produced by EVICEL were significantly higher than those of clots produced by TISSEEL (P < 0.05 for both). The mean time to initial clot formation and mean time to the predefined level of clot formation were numerically shorter for EVICEL compared with TISSEEL. Furthermore, mean maximal amplitude of the clots formed with EVICEL was significantly greater than that for the clots formed with TISSEEL. Mean concentration of factor XIII for the EVICEL fibrinogen samples tested was 9 IU/ml compared with undetectable concentrations of factor XIII for the TISSEEL fibrinogen samples. Fibrin clots formed with EVICEL have a much higher resistance to stretching and tensile strength and are more capable of maintaining their structure against applied force than those formed with TISSEEL. EVICEL also allows more rapid development of fibrin clots than TISSEEL. This superior clot strength and resilience obtained with EVICEL relative to TISSEEL may be due in large part to the presence of factor XIII.

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Section: Evicel Fibrin Sealant (Human) (Johnson and Johnsonmentioning

confidence: 99%

A comparison of the mechanical, kinetic, and biochemical properties of fibrin clots formed with two different fibrin sealants

Hickerson

Nur²,

Meidler³

2011

Blood Coagulation &Amp; Fibrinolysis

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“…18 A biomechanical evaluation of fibrin glue augmentation of a 2-suture epineural repair demonstrated improved resistance to gapping (p Ͻ .05) but no significant additional repair strength. 19 Despite this, for well-protected, tension-free repairs, this tool can be very effective. Multiple animal studies report superiority or at least equivalency to suture repair.…”

mentioning

confidence: 99%

Treatment of Acute Peripheral Nerve Injuries: Current Concepts

Isaacs

2010

The Journal of Hand Surgery

121

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“…According to a recent cadaver study, Tisseel, Evicel, and DuraSeal all helped prevent initial gapping but did not increase the load to failure of the repair. 39 Other methods of nerve repair Other methods examined in nerve repair include freeze-thawed muscle graft, nerve transfer, and direct muscular neurotization. Thus far, freeze-thawed muscle graft has shown only equivocal results.…”

Section: Nerve Graftsmentioning

confidence: 99%