Comparative Analysis of Acute Cutaneous Lupus Erythematosus with Subacute and Chronic Cutaneous Lupus Erythematosus: Clinical and Immunological Study of 308 Patients

Recabarren, Mauricio A. Vera; Carrasco, Mario García

doi:10.4172/2167-7921.1000185

Cited by 1 publication

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are similar to the literature on Asian [ 14 , 15 ] and Black people [ 20 , 21 ], as well as Caucasian people [ 2 , 9 , 21 , 22 ]. Although statistically insignificant, patients with SCLE and CCLE were older than those with ACLE, corresponding to previous studies [ 23 , 24 ]. We found substantial differences in gender distribution between CLE subtypes, with the highest female predominance in ACLE and CCLE with SLE (female-to-male ratio of 20:1 and 10:1, respectively).…”

Section: Discussionsupporting

confidence: 83%

“…Our results are similar to the literature on Asian [14,15] and Black people [20,21], as well as Caucasian people [2,9,21,22]. Although statistically insignificant, patients with SCLE and CCLE Bold indicates statistically significant ACLE acute cutaneous lupus erythematosus, ANA Anti-nuclear antibody; Anti-dsDNA anti-double stranded DNA antibodies, Anti-Sm antibody Anti-Smith antibody, C complement, CCLE chronic cutaneous lupus erythematosus, ESR erythrocyte sedimentation rate, SCLE subacute cutaneous lupus erythematosus, SLEDAI-2K Systemic Lupus Erythematosus Disease Activity Index were older than those with ACLE, corresponding to previous studies [23,24]. We found substantial differences in gender distribution between CLE subtypes, with the highest female predominance in ACLE and CCLE with SLE (female-to-male ratio of 20:1 and 10:1, respectively).…”

Section: Discussionsupporting

confidence: 72%

See 1 more Smart Citation

Dermatologic Manifestations, Histologic Features and Disease Progression among Cutaneous Lupus Erythematosus Subtypes: A Prospective Observational Study in Asians

Chanprapaph

Tankunakorn

Suchonwanit

et al. 2020

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

Introduction Cutaneous manifestations are central to the primary diagnosis of systemic lupus erythematosus (SLE). However, information on the clinical, histopathologic, and direct immunofluorescence (DIF) features among subtypes of cutaneous lupus erythematosus (CLE), as well as longitudinal prospective observational study to evaluate the natural history and the progression to SLE, is lacking among Asians. Our objectives are to summarize the differences in the clinical, histopathologic, and DIF characteristics and serological profiles between various subtypes of CLE, and to provide its natural history and the association with disease activity in our Asian population. Methods A prospective observational study on CLE patients was performed between May 2016 and May 2020. Patients underwent full physical/dermatologic examination, skin biopsy for histology, and DIF. Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) scores and laboratory data were evaluated. Time schedule and characteristics for resolution and/or the disease progression to SLE were recorded in subsequent follow-ups. Results Of 101 biopsy-proven CLE patients, 25 had acute CLE (ACLE), 8 had subacute CLE (SCLE), 39 had chronic CLE (CCLE) only, 22 had CCLE with SLE, and 7 had LE-nonspecific cutaneous lesions only. Patients with exclusive CLE showed lower female preponderance, serological abnormalities, and correlation to systemic disease. However, when CLE was accompanied with any LE-nonspecific cutaneous manifestations, they were associated with high antinuclear antibody (ANA) titer, renal, hematologic, joint involvement, and greater SLEDAI score. Of 207 biopsy sections, SCLE/CCLE regardless of systemic involvement showed significantly higher percentage of superficial/deep perivascular and perieccrine infiltration than ACLE. On DIF, deposition of multiple immunoreactants was associated with higher systemic disease. Approximately 10% of CLE-only patients later developed SLE but had mild systemic involvement. Conclusion Our findings support that each CLE subtype has a diverse and unique character. Comprehensive understanding of the differences among CLE subtypes is important for achieving the correct diagnosis and providing appropriate disease monitoring and management. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-020-00471-y.

show abstract

“…Our results are similar to the literature on Asian [ 14 , 15 ] and Black people [ 20 , 21 ], as well as Caucasian people [ 2 , 9 , 21 , 22 ]. Although statistically insignificant, patients with SCLE and CCLE were older than those with ACLE, corresponding to previous studies [ 23 , 24 ]. We found substantial differences in gender distribution between CLE subtypes, with the highest female predominance in ACLE and CCLE with SLE (female-to-male ratio of 20:1 and 10:1, respectively).…”

Section: Discussionsupporting

confidence: 83%

“…Our results are similar to the literature on Asian [14,15] and Black people [20,21], as well as Caucasian people [2,9,21,22]. Although statistically insignificant, patients with SCLE and CCLE Bold indicates statistically significant ACLE acute cutaneous lupus erythematosus, ANA Anti-nuclear antibody; Anti-dsDNA anti-double stranded DNA antibodies, Anti-Sm antibody Anti-Smith antibody, C complement, CCLE chronic cutaneous lupus erythematosus, ESR erythrocyte sedimentation rate, SCLE subacute cutaneous lupus erythematosus, SLEDAI-2K Systemic Lupus Erythematosus Disease Activity Index were older than those with ACLE, corresponding to previous studies [23,24]. We found substantial differences in gender distribution between CLE subtypes, with the highest female predominance in ACLE and CCLE with SLE (female-to-male ratio of 20:1 and 10:1, respectively).…”

Section: Discussionsupporting

confidence: 72%