Comparative analyses of umbilical cord lead concentration in term and IUGR complicated neonates

Gharehzadehshirazi, Azadeh; Kadivar, Maliheh; Shariat, Mamak; Shirazi, Mahboobeh; Zarkesh, Mohammad Reza; Najed, Maryam Ghanavati

doi:10.1080/14767058.2019.1620726

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Several studies have found that higher levels of prenatal Pb exposure was associated with lower birth weight [9][10][11][12][13][14], reduced birth length [9,10,13], and/or reduced head or chest circumference [9,13,15]. While some studies have observed a null association [16][17][18], the accumulated evidence suggests gestational Pb exposure is an important risk factor for birth outcomes. Likewise, maternal depression is an important perinatal risk factor because of its potential to contribute to deleterious outcomes for both the mother and infant, and its relative high prevalence in the population [19].…”

Section: Introductionmentioning

confidence: 99%

Prenatal Lead and Depression Exposures Jointly Influence Birth Outcomes and NR3C1 DNA Methylation

Appleton

Kiley

Schell

et al. 2021

IJERPH

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Many gestational exposures influence birth outcomes, yet the joint contribution of toxicant and psychosocial factors is understudied. Moreover, associated gestational epigenetic mechanisms are unknown. Lead (Pb) and depression independently influence birth outcomes and offspring NR3C1 (glucocorticoid receptor) DNA methylation. We hypothesized that gestational Pb and depression would jointly influence birth outcomes and NR3C1 methylation. Pregnancy exposure information, DNA methylation, and birth outcome data were collected prospectively from n = 272 mother–infant pairs. Factor analysis was used to reduce the dimensionality of NR3C1. Multivariable linear regressions tested for interaction effects between gestational Pb and depression exposures with birth outcomes and NR3C1. Interaction effects indicated that higher levels of Pb and depression jointly contributed to earlier gestations, smaller infant size at birth, and asymmetric fetal growth. Pb and depression were also jointly associated with the two primary factor scores explaining the most variability in NR3C1 methylation; NR3C1 scores were associated with some infant outcomes, including gestational age and asymmetric fetal growth. Pb and depression can cumulatively influence birth outcomes and epigenetic mechanisms, which may lay the foundation for later health risk. As toxicants and social adversities commonly co-occur, research should consider the life course consequences of these interconnected exposures.

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