Comparative Analyses of the Subgingival Microbiome in Chronic Periodontitis Patients with and without Gingival Erosive Oral Lichen Planus Based on 16S rRNA Gene Sequencing

Abstract

The aim of the study was to compare the microbiota composition and bacterial diversity of subgingival plaque in chronic periodontitis patients with and without gingival erosive oral lichen planus. The subgingival plaque samples of 20 chronic periodontitis patients with gingival erosive oral lichen planus (CP-OLP group) and 19 chronic periodontitis patients without gingival erosive oral lichen planus (CP group) were analyzed by 16S rRNA gene high-throughput sequencing. Compared with the CP group, the richness and diversity of subgingival plaque microflora in the CP-OLP group decreased significantly. There were some differences between the two groups in the composition of microflora on the levels of phylum and genus. Distributions of Prevotella and Leptotrichia in the CP-OLP group were significantly lower than those in the CP group. The dominant genera in CP-OLP group were Pseudomonas and Granulicatella. These results indicated that gingival erosive oral lichen planus may influence the structure and proportion of subgingival plaque microflora.

Lactobacillus paracasei ET-22 and derived postbiotics reduce halitosis and modulate oral microbiome dysregulation – a randomized, double-blind placebo-controlled clinical trial

“…The three genera are part of the commensal oral microbial community and are generally considered to be harmless colonizers associated with oral health, such as dental caries, periodontitis and other infections. 32,33 However, the relationship between genera and VSCs has not yet been understood, especially for Rothia and Granulicatella. In our study, ET-22.HK intervention significantly decreased the abundance of Rothia and Streptococcus.…”

Management of Gingival Oral Lichen Planus with Free Gingival Graft: 10-Year Follow-Up Case Report

“…The patient was in a vicious cycle. Previous studies reported that plaques might prevent gingival OLP lesions from healing, which changes the characteristics of the lesions into more aggressive forms, such as erosive lesions [11], whereas plaque control improves the painful symptoms of gingival OLP [12][13][14]. To break the vicious cycle, controlling severe OLP symptoms and signs was prioritized.…”

Advancements in the Relationship Between Oral Lichen Planus and Microbial Infections

“…The results indicated that actinomycetes, Aiken rodents, and Clostridium nucleatum detection frequencies in subgingival flora were considerably greater in OLP patients compared in non-OLP patients. According to Liu et al [12], the number of Pseudomonas and Streptococcus granulosus in the subgingival plaque flora of patients with gingival erosive OLP increased significantly, indicating that changing the flora composition can disrupt the original flora balance, destroy the epithelial barrier, and lead to the development of OLP lesions.…”