Comparative Analyses of DHA‐Phosphatidylcholine Forage and Liposomes on Alzheimer's Disease in SAMP8 Mice

Abstract

The present work comparatively evaluates the efficacy of docosahexaenoic acid – phosphatidylcholine (DHA‐PC) forage and liposome on Alzheimer's disease (AD) in the senescence‐accelerated prone 8 (SAMP8) mice and illustrates the potential mechanism. The dose of DHA‐PC in forage group (1% of total diets) is equal to that of liposome group. The results of Morris maze test show that both DHA‐PC forage and liposome obviously alleviated cognitive impairment (P < 0.05). Moreover, the administration of DHA‐PC liposome shows advantage than forage in reducing β‐amyloid (Aβ) accumulation (P < 0.05). Meanwhile, DHA‐PC forage exhibits excellent inhibition on the IL‐1β protein expression (P < 0.05) and improvement in the protein levels of SYN and BDNF (P < 0.05). These data are the first to perform comparative analysis of DHA‐PC forage and liposome on AD. Practical Applications: The outcomes in the present study might help to understand the bioactivities of DHA‐PC forage and liposomes, which might exert potential application value for dietary supplement with neuroprotective effects. Both docosahexaenoic acid – phosphatidylcholine (DHA‐PC) forage and liposome shows benefits in alleviating Alzheimer's disease development in senescence‐accelerated prone 8 mice by inhibiting β‐amyloid generation, oxidative stress, apoptosis, neural inflammation, and enhancing neurotrophins pathway in different degrees.

Omega‐3 polyunsaturated fatty acid encapsulation system: Physical and oxidative stability, and medical applications

“…Meng et al. (2019) extracted DHA‐rich oil from squid roe and separated the oil with phospholipids to prepare DHA liposomes. SAMP8 rats on high‐fat diet (HF) were supplemented with DHA liposomes, and the learning and memory abilities of the rats were evaluated by Morris water maze method.…”

“…Meng et al. (2019) believed that the phospholipid bilayer structure of liposomes could improve the permeability and transport of cells to DHA. Therefore, DHA liposomes might have a stronger effect than commercial DHA in inhibiting AD or Parkinson's disease.…”

“…believed that the phospholipid bilayer structure of liposomes could improve the permeability and transport of cells to DHA. Therefore, DHA liposomes might have a stronger effect than commercial DHA in inhibiting AD or Parkinson's disease Meng et al (2019). extracted DHA-rich oil from squid roe and separated the oil with phospholipids to prepare DHA liposomes.…”

“…This is due to the deposition of β-amyloid in the brain and the vascular damage caused by the apoptosis of brain neurons. DHA as a dietary supplement is considered a safe way to prevent AD Meng et al (2019). believed that the phospholipid bilayer structure of liposomes could improve the permeability and transport of cells to DHA.…”

Nanodelivery of the Gramicidin Peptide for Enhancing Antimicrobial Activity

“…[ 9,10 ] These liposomes with nanosized dimensions are one of the most studied nanocarrier systems for drug delivery mainly because of its relatively simple preparation method, high efficacy, biocompatibility, biodegradation, capability of enhance solubility of therapeutic agents and versatility to encapsulate different kind of drugs. [ 11–13 ] Furthermore, composition of liposomal membrane can be strategically design according to the subsequent application.…”