Comparative Analgesic Efficacy of Patient-Controlled Analgesia with Ketorolac Versus Morphine After Elective Intraabdominal Operations

Cepeda, M. Soledad; Vargas, L F Cabrera; Ortegon, Gloria; Sánchez, María Dolores Martín; Carr, Daniel B.

doi:10.1213/00000539-199506000-00014

Anesthesia & Analgesia

1995

DOI: 10.1213/00000539-199506000-00014

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Comparative Analgesic Efficacy of Patient-Controlled Analgesia with Ketorolac Versus Morphine After Elective Intraabdominal Operations

M. Soledad Cepeda

L F Cabrera Vargas

Gloria Ortegon

et al.

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Cited by 5 publications

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Evaluation of the Safety and Efficacy of Ketorolac versus Morphine by Patient‐Controlled Analgesia for Postoperative Pain

O'Hara,

Fanciullo,

Hubbard

et al. 1997

Pharmacotherapy

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Study Objective. To compare ketorolac tromethamine with morphine for pain management after major abdominal surgery.Design. Double‐blind, randomized studySetting. Hospital recovery room and postoperative surgical unit.Patients. One hundred ninety‐one patients with at least moderate pain after major abdominal surgery.Interventions. Patients received ketorolac by patient‐controlled analgesia (PCA) bolus alone (Ket B), ketorolac by bolus plus infusion (Ket I), or morphine by PCA bolus (morphine), with injectable morphine available for supplementation.Measurements and Main Results. Levels of sedation, pain intensity, pain relief, and adverse events were recorded at baseline, at 2, 4, and 6 hours, and at termination. Supplemental morphine was required by 71% of Ket B patients, 67% of Ket I patients, and 38% of morphine patients (p<0.001 for Ket B vs morphine). Although patients receiving ketorolac required more supplemental morphine than the morphine group (6.0 mg Ket I, 6.2 mg Ket B, 4.0 mg morphine), there was a large morphine‐sparing effect in both ketorolac groups (total morphine 6.0 mg Ket I, 6.2 mg Ket B, 33.3 mg morphine). Overall pain relief scores were similar for morphine and Ket I groups, and were lower for Ket B than for morphine (p=0.002). There were no differences among groups in numbers of patients with adverse events.Conclusion. Ketorolac may be effective when administered by PCA device, and has a clear morphine‐sparing effect. (Pharmacotherapy 1997;17(5):891–899)

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Evaluation of the Safety and Efficacy of Ketorolac versus Morphine by Patient‐Controlled Analgesia for Postoperative Pain

O'Hara,

Fanciullo,

Hubbard

et al. 1997

Pharmacotherapy

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Clinical trial: alvimopan for the management of post‐operative ileus after abdominal surgery: results of an international randomized, double‐blind, multicentre, placebo‐controlled clinical study

Büchler

Seiler

Monson

et al. 2008

Aliment Pharmacol Ther

124

119

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Bowel function after bowel surgery: morphine with ketamine or placebo; a randomized controlled trial pilot study

McKay

Donais

2007

Acta Anaesthesiol Scand

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Comparative Analgesic Efficacy of Patient-Controlled Analgesia with Ketorolac Versus Morphine After Elective Intraabdominal Operations

Cited by 5 publications

References 18 publications

Evaluation of the Safety and Efficacy of Ketorolac versus Morphine by Patient‐Controlled Analgesia for Postoperative Pain

Evaluation of the Safety and Efficacy of Ketorolac versus Morphine by Patient‐Controlled Analgesia for Postoperative Pain

Clinical trial: alvimopan for the management of post‐operative ileus after abdominal surgery: results of an international randomized, double‐blind, multicentre, placebo‐controlled clinical study

Bowel function after bowel surgery: morphine with ketamine or placebo; a randomized controlled trial pilot study

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