The stagnation of labour productivity growth over the last decades, as well as the changing role of conventional variables, has revived policy makers’ and scholars’ interest in exploring other potential sources of growth. Hence, this study uses a recent data of 102 countries from 1990 – 2017 and the New Structural Economics Hypothesis, to investigate the impact of comparative advantage development strategy on labour productivity growth. The results, based on the two-step Generalized Methods of Moments, show that defying comparative advantage development strategy has a detrimental effect on labour productivity growth. However, further analysis of the existence of a non-linearity impact indicates some heterogeneity across countries. High and upper middle-income countries benefit from defying their comparative advantage till a certain point where the gains turn negative, while the negative effect between the defiance of comparative advantage and labour productivity persisted for lower middle- and low-income countries. Also, the results provide evidence of positive impact of institutional quality and trade openness on labour productivity growth.