Comparative acute toxicity of the first 50 Multicentre Evaluation of In Vitro Cytotoxicity chemicals to aquatic non-vertebrates

Calleja, Mc; Persoone, G.; Geladi, Paul

doi:10.1007/bf00212796

Cited by 111 publications

(45 citation statements)

References 51 publications

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“…Fourty-eight-hour L(E)C values for A. sardeus and D. magna were 42.2 and 1 g/L, respectively. The low toxicity of malathion to Streptocephalus in the present experiments con"rms the results of Calleja et al (1994) and Crisinel et al (1994) who reported 24-h LC values of the substance for three Streptocephalus species ranging from 54.6 to 81.5 mg/L, even though these investigators used larvae instead of adults. Because malathion (a phosphorodithioate with a succinate leaving group) belongs to another group of organophosphates than chlorpyrifos and fenitrothion (both phosphorothioates, but with a heterocyclic and a phenyl leaving group, respectively), these results indicate that there may exist a biochemical basis for the relative insensitivity of Streptocephalus to malathion.…”

Section: Toxicitysupporting

confidence: 91%

Acute Toxicity of Locust Insecticides to Two Indigenous Invertebrates from Sahelian Temporary Ponds

Lahr

Badji²,

Marquenie

et al. 2001

Ecotoxicology and Environmental Safety

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Section: Toxicitysupporting

confidence: 91%

Acute Toxicity of Locust Insecticides to Two Indigenous Invertebrates from Sahelian Temporary Ponds

Lahr

Badji²,

Marquenie

et al. 2001

Ecotoxicology and Environmental Safety

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“…Nałęcz-Jawecki & Persoone (2006) present toxicity information for several pharmaceuticals using T. platyurus. From the data published by these authors and those reported by Calleja et al (1994) on assays with A. salina, it also appears that T. platyurus is more sensitive to paracetamol, caffeine and theophylline.…”

Section: Resultsmentioning

confidence: 69%

Comparison of bioassays using the anostracan crustaceans Artemia salina and Thamnocephalus platyurus for plant extract toxicity screening

Mayorga¹,

Pérez²,

Cruz³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Comparação de bioensaios com os crustáceos Artemia salina e Thamnocephalus platyurus para abordagem de extratos de plantas com toxicidade". Três bioensaios de letalidade com o crustáceo de água salgada Artemia salina Leach, Artemiidae, (teste convencional em microplaca de 96 poós Artoxkit microbiotest M) e o crustáceo de água doce Thamnocephalus platyurus Packard, Thamnocephalidae (Thamnotoxkit microbiotest F), foram comparados utilizando extratos de dez espécies de plantas da Guatemala. Foi previamente observado que cinco delas possuem atividade anti-Artemia: Solanum americanum Mill., Solanaceae, Gliricidia sepium (Jacq.) Kunth ex Walp., Fabaceae, Neurolaena lobata (L.) Cass., Asteraceae, Petiveria alliacea L., Phytolaccaceae e Ocimum campechianum Mill., Lamiaceae. As outras cinco espécies, Curatella americana L., Dilleniaceae, Prunus barbata Koehne, Rosaceae, Quercus crispifolia Trel., Fagaceae, Rhizophora mangle L., Rhizophoraceae e Smilax domingensis Willd., Smilacaceae, não. Todas as plantas sem atividade anti-Artemia não tiveram nenhum efeito letal em ambos os ensaios com A. salina. Para as plantas com atividade anti-Artemia o M Artoxkit não foi sensível a G. sepium e teste convencional de Artemia não foi sensível a S. americanum, G. sepium e N. lobata. Todos os extratos vegetais, exceto o de C. americana, apresentaram um efeito letal sobre T. platyurus e a concentração letal média (CL50) para este organismo em todos os casos foram substancialmente inferiores aos da espécie de teste de água salgada. Este estudo revelou que T. platyurus é teste promissor para uma investigação aprofundada na seleção de extratos de plantas com potenciais propriedades medicinais.Unitermos: Plantas medicinais, toxicidade, Artemia salina, Thamnocephalus platyurus, Artoxkit M, Thamnotoxkit F.ABSTRACT: Three lethality bioassays, using the salt-water crustacean Artemia salina Leach, Artemiidae, (conventional 96 microwell plate test and the Artoxkit M microbiotest) and the freshwater crustacean Thamnocephalus platyurus Packard, Thamnocephalidae, (Thamnotoxkit F microbiotest), were compared using extracts of ten Guatemalan plant species. It was previously observed that five of them have anti-Artemia activity. These were: Solanum americanum Mill., Solanaceae, Gliricidia sepium (Jacq.) Kunth ex Walp., Fabaceae, Neurolaena lobata (L.) Cass., Asteraceae, Petiveria alliacea L., Phytolaccaceae, and Ocimum campechianum Mill., Lamiaceae. The five others: Curatella americana L., Dilleniaceae, Prunus barbata Koehne, Rosaceae, Quercus crispifolia Trel., Fagaceae, Rhizophora mangle L., Rhizophoraceae, and Smilax domingensis Willd., Smilacaceae, do not. All plants without anti-Artemia activity had no lethal effects in both assays with A. salina. For the plants with anti-Artemia activity the Artoxkit M was not sensitive to G. sepium and the conventional Artemia test was not sensitive to S. americanum, G. sepium and N. lobata. All the plant extracts, except for that of C. americana, had lethal effects on T. platyurus and the lethal median ...

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“…The commercial Microtox ® assay system is also an acute bioassay designed to detect basal toxicity to the marine luminescent bacteria Photobacterium phosphoreum, mostly from some organic substances [27]. Many other standardised in vitro cytotoxicity tests have been developed to test a large number of chemicals [28]. Acute lethality is typically determined for single doses at 24 h in terrestrial organisms and after a fixed time of exposure in aquatic organisms: from 24 or 48 h in small organisms to 96 h for larger crustaceans and fish.…”

Section: Toxicity Assessmentmentioning

confidence: 99%

Environmental Risk Assessment of Agrochemicals — A Critical Appraisal of Current Approaches

Sánchez‐Bayo¹,

Tennekes²

2015

Toxicity and Hazard of Agrochemicals

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This chapter provides insights into the difficulties and challenges of performing risk evaluations of agrochemicals. It is a critical review of the current methodologies used in ecological risk assessment of these chemicals, not their risks to humans. After an introduction to the topic, the current framework for ecological risk assessment is outlined. Two types of assessments are typically carried out depending on the purpose: i) regulatory assessments for registration of a chemical product; and ii) ecological assessments, for the protection of both terrestrial and aquatic ecosystems, which are usually site-specific. Although the general framework is well established, the methodologies used in each of the steps of the assessment are fraught with a number of shortcomings. Notwithstanding the subjectivity implicit in the evaluation of risks, there is scepticism in scientific circles about the appropriateness of the current methodologies because, after so many years of evaluations, we are still incapable of foreseeing the negative consequences that some agrochemicals have in the environment. A critical appraisal of such methodologies is imperative if we are to improve the current assessment process and fix the problems we face today. The chapter reviews first the toxicity assessment methods, pointing to the gaps in knowledge about this essential part of the process and suggesting avenues for further improvement. Deficiencies in the current regulations regarding toxicity testing are discussed, in particular the effect of the time factor on toxicity and the issue of complex mixtures.

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Comparative acute toxicity of the first 50 Multicentre Evaluation of In Vitro Cytotoxicity chemicals to aquatic non-vertebrates

Cited by 111 publications

References 51 publications

Acute Toxicity of Locust Insecticides to Two Indigenous Invertebrates from Sahelian Temporary Ponds

Acute Toxicity of Locust Insecticides to Two Indigenous Invertebrates from Sahelian Temporary Ponds

Comparison of bioassays using the anostracan crustaceans Artemia salina and Thamnocephalus platyurus for plant extract toxicity screening

Environmental Risk Assessment of Agrochemicals — A Critical Appraisal of Current Approaches

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