Comparative activities of compounds of the androsterone-testosterone series

Deanesly, Ruth; Parkes, A. S.

doi:10.1042/bj0300291

Cited by 47 publications

(10 citation statements)

References 5 publications

(1 reference statement)

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“…The geometry of the steroid molecule at certain centers of asymmetry is known to be a critical factor in hormonal activity (3,21). This fact is substantiated by the present experimental results.…”

Section: Discussionsupporting

confidence: 80%

Chemical Structure of Steroids in Relation to Promotion of Growth of the Vagina and Uterus of the Hypophysectomized Rat

Huggins

Jensen

Cleveland

1954

Journal of Experimental Medicine

115

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In the hypophysectomized albino rat which is protected from contact with steroids in the ration and environment the uterus and vagina are highly atrophic but are sensitive indicators of activity of substances which promote their growth. Both the pituitary growth hormone and certain steroids have the common property of inducing growth of these tissues. The vaginal epithelium consists of 2 layers of cells which differ profoundly in their growth in response to steroids, depending on the molecular structure of these compounds. The differential response to modifications of chemical structures of steroids permits evaluation of the importance of the intramolecular components for the process of growth. The number and site of functional groups, the geometry of the molecule and the state of oxidation are of high importance in determining physiologic activity of steroids in the androstane series; these features are less specific in the estrane series. Side groups at positions C3 and C17 are of importance in the promotion of growth by steroids in the androstane series, but these active centers are not equivalent in their physiological influence. As a generalization, hydrogenation of the oxygen function at C17 (but not at C3) and dehydrogenation at critical areas of the ring structure increase the quantitative efficacy of steroids in promoting growth. The position of double bonds and the state of oxidation at both C3 and C17 determine the qualitative type of growth—cellular pattern, which a compound in the androstane series induces in the vaginal epithelium.

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Section: Discussionsupporting

confidence: 80%

Chemical Structure of Steroids in Relation to Promotion of Growth of the Vagina and Uterus of the Hypophysectomized Rat

Huggins

Jensen

Cleveland

1954

Journal of Experimental Medicine

115

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“…Assays to detect androgenic properties have been developed since the 1930s (Korenchevsky, 1932;Korenchevsky et al, 1932Korenchevsky et al, , 1933aBülbring and Burn, 1935;Dingemanse et al, 1935;Deanesly and Parkes, 1936;Wainman and Shipounoff, 1941;Eisenberg et al, 1949;Eisenberg and Gordan, 1950;Di Salle et al, 1994), and the capabilities of the assays were demonstrated in 1953 by Hershberger et al when they analyzed the response of the ventral prostate, seminal vesicles and coagulating glands, and the levator ani without the bulbocavernosus muscle to a number of active chemicals, including estrogens and progesterones (Hershberger et al, 1953).…”

Section: Introductionmentioning

confidence: 98%

Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals

et al. 2004

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“…Uzun süreli etkin madde verilişinin, implante edilen ilaç salım sistemi şeklindeki uygulaması beşeri kullanım amacıyla düşünülmüş ve ilk kez 1861 yılında Lafarge`ın subkütan olarak implante edilen etkin madde pelletlerini geliştirmesi ile başlamıştır (1) (6,7,8). 1990`larda ise biyoparçalanabilir mikropartiküler şekiller geliştirilmiştir (9).…”

Section: Introductionunclassified

Sürekli etkili implant sistemlerin veteriner alandaki uygulamaları : veterinary applications of sustained release implant systems

Alğin¹

1956

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Comparative activities of compounds of the androsterone-testosterone series

Cited by 47 publications

References 5 publications

Chemical Structure of Steroids in Relation to Promotion of Growth of the Vagina and Uterus of the Hypophysectomized Rat

Chemical Structure of Steroids in Relation to Promotion of Growth of the Vagina and Uterus of the Hypophysectomized Rat

Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals

Sürekli etkili implant sistemlerin veteriner alandaki uygulamaları : veterinary applications of sustained release implant systems

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