Comparaison des classifications TNM des 8es éditions de l’UICC et de l’AJCC en uropathologie

Compérat, Éva; Varinot, Justine; Eymerit, Caroline; Paner, Gladell P.; Hansel, Donna E.; Amin, Mahul B.; Moroch, Julien

doi:10.1016/j.annpat.2018.12.005

Cited by 12 publications

(4 citation statements)

References 32 publications

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“…The exclusion criterion was having a history of malignancy in other organs. The clinical staging was performed using the Scarf–Bloom–Richardson criteria and the TNM staging system for BC (Comperat et al, ; Elston, ).…”

Section: Methodsmentioning

confidence: 99%

miR‐483‐3p suppresses the proliferation and progression of human triple negative breast cancer cells by targeting the HDAC8>oncogene

Menbari

Rahimi

Ahmadi

et al. 2019

Journal Cellular Physiology

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Triple negative breast cancer (TNBC) is a heterogeneous subclass of breast cancer (BC) distinguished by lack of hormone receptor expression. It is highly aggressive and difficult to treat with traditional chemotherapeutic regimens. Targeted-therapy using microRNAs (miR) has recently been proposed to improve the treatment of TNBC in the early stages. Here, we explore the roles of miR-483-3p/HDAC8 HDAC8 premiRvector on tumorigenicity in TNBC patients. Clinical TNBC specimens and three BC cell lines were prepared. miR-483-3p and expression levels were measured using quantitative real-time polymerase chain reaction. Cell cycle progression was assessed by a flow-cytometry method. We also investigated cell proliferation by 3-2, 5-diphenyl tetrazolium bromide assay and colony formation assay. We used a to overexpress miR-483-3p, and a HDAC8-KO-vector for knocking out the endogenous production of HDAC8. Our data showed significant downregulation of miR-483-3p expression in TNBC clinical and cell line samples. The HDAC8 was also upregulated in both tissue specimens and BC cell lines. We found that increased levels of endogenous miR-483-3p affects tumorigenecity of MDA-MB-231. Downregulation of HDAC8 using the KO-vector showed the same pattern. Our results revealed that the miR-483-3p suppresses cellular proliferation and progression in TNBC cell lines via targeting HDAC8. Overall, our outcomes demonstrated the role of miR-483-3p as a tumor suppressor in TNBC and showed the possible mechanism via HDAC8. In addition, targeted treatment of TNBC with miR-483-3p might be considered in the future.

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Section: Methodsmentioning

confidence: 99%

miR‐483‐3p suppresses the proliferation and progression of human triple negative breast cancer cells by targeting the HDAC8>oncogene

Menbari

Rahimi

Ahmadi

et al. 2019

Journal Cellular Physiology

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“…The ECOG Performance Status also called WHO (World Health Organization) Performance Status is an assessment of the patients’ actual level of function and capability of self-care [ 12 ]. Cancer cases were staged according to the UICC-TNM (Union for International Cancer Control- Tumor, Node, Metastasis) classification and the AJCC (American Joint Committee on Cancer) classification [ 13 ] based on the data obtained from the medical records. The American College of Radiology (ACR) classification was collected from the imaging reports, and the Scarf Bloom and Richardson (SBR) histopronostic grade [ 14 ] was reported from the pathology reports.…”

Section: Methodsmentioning

confidence: 99%

Prognostic factors and overall survival of breast cancer in Benin: a hospital-based study

Gnangnon,

Parenté,

Aboubakar

et al. 2024

BMC Women's Health

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Background In Benin, a country in West Africa, breast cancer is the leading cancer in women, both in terms of incidence and mortality. However, evidence on the mortality of breast cancer and its associated factors is lacking in this country. Our aim was to describe and analyze the clinical, histopathological, and prognostic aspects of breast cancer in Benin. Methods A descriptive and analytical study was carried out at the CNHU-HKM and the CHU-MEL, two major tertiary referral hospitals for breast cancer management located in Cotonou, the capital city of Benin. All breast cancer medical records with histological evidence and immunohistochemistry studies were retrospectively collected between January 1, 2014, and September 30, 2020, in these two tertiary referral hospitals and analyzed in the current study. Results Finally, 319 medical records were included. The mean age at diagnosis was 48.74 years. The tumors were most frequently classified as T4 (47.6%) with lymph node involvement N2 (34.5%), and metastases were clinically noted in 21.9% of cases. Stage was reported in the medical records of 284 patients. Tumors were diagnosed at very late AJCC stages: stage III (47.5%) and stage IV (24.7%). Grades SBR 2 (49.2%) and SBR 3 (32.6%) were the most frequent grades. Triple-negative breast cancer (31.3%) was the most common molecular type. The overall 5-year survival was 48.49%. In multivariable analysis, the poor prognostic factors were lymph node invasion (HR = 2.63; p = 0.026; CI: [1.12, 6.17]), the presence of metastasis (HR = 3.64; p < 0.001); CI: [2.36, 5.62] and the immunohistochemical profile (HR = 1.29; p < 0.001; CI: [1.13, 1.48]). Conclusions Breast cancer in Beninese is predominant in young adults and is often diagnosed at a late stage. The survival of breast cancer patients in Benin can be improved by enhancing early diagnosis and multidisciplinary management.

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“…General status was estimated using the WHO performance status at the rst medical visit after cancer diagnosis (10). Cancer cases were staged according to the UICC TNM classi cation and the AJCC classi cation (11) based on the data obtained from the medical records. The American College of Radiology (ACR) classi cation was collected from the imaging reports, and the Scarf Bloom and Richardson (SBR) histopronostic grade (12) was reported from the pathology reports.…”

Section: Data Collectionmentioning

confidence: 99%

Prognostic factors and overall survival of breast cancer in Benin: a hospital-based study

Gnangnon¹,

Parenté²,

Aboubakar

et al. 2023

Preprint

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Background In Benin, a country in West Africa, breast cancer is the leading cancer in women, both in terms of incidence and mortality. However, evidence on the mortality of breast cancer and its associated factors is lacking in this country. Our aim was to describe and analyze the clinical, histopathological, and prognostic aspects of breast cancer in Benin. Methods A descriptive and analytical study was carried out at the CNHU-HKM and the CHU-MEL, two major referral hospitals for breast cancer management located in Cotonou, the capital city of Benin. All breast cancer medical records with histological evidence and immunohistochemistry studies were retrospectively collected between January 1, 2014, and September 30, 2020, in these two referral hospitals and analyzed in this study. Results We included 319 medical records. The mean age at diagnosis was 48.74 years. The tumors were most frequently classified as T4 (47.6%) with lymph node involvement N2 (34.5%), and metastases were clinically noted in 21.6% of cases. Tumors were diagnosed at very late AJCC stages: stage 3 (42.3%) and stage 4 (21.9%). Grades SBR 2 (49.2%) and SBR 3 (32.6%) were the most frequent grades. Triple-negative breast cancer (31.3%) was the most common molecular type. The overall 5-year survival was 48.49%. In multivariable analysis, the poor prognostic factors were lymph node invasion (HR = 2.63; p = 0.026; CI: [1.12, 6.17]), the presence of metastasis (HR = 3.64; p < 0,001); CI: [2.36, 5.62] and the immunohistochemical profile (HR = 1.29; p < 0,001; CI: [1.13, 1.48]). Conclusions Breast cancer in Beninese is predominant in young adults and is often diagnosed at a late stage. The survival of breast cancer patients in Benin can be improved by enhancing early diagnosis and multidisciplinary management.

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Comparaison des classifications TNM des 8es éditions de l’UICC et de l’AJCC en uropathologie

Cited by 12 publications

References 32 publications

miR‐483‐3p suppresses the proliferation and progression of human triple negative breast cancer cells by targeting the HDAC8>oncogene

miR‐483‐3p suppresses the proliferation and progression of human triple negative breast cancer cells by targeting the HDAC8>oncogene

Prognostic factors and overall survival of breast cancer in Benin: a hospital-based study

Prognostic factors and overall survival of breast cancer in Benin: a hospital-based study

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