Comparaison de l’efficacité de l’artémether et de la quinine dans le traitement du paludisme grave chez les enfants à Bangui, République centrafricaine

Bobossi-Serengbe, G.; Gody, J. C.; Fioboy, R.; Elowa, J. B.; Manirakiza, Alexandre

doi:10.1007/s13149-015-0428-3

Cited by 9 publications

(9 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of these, there was only one potentially eligible article. This new study met the inclusion criteria (Bobossi‐Serengbe 2015).…”

Section: Resultsmentioning

confidence: 99%

“…In this review update, we included one additional RCT enrolling 212 participants (children aged between six and 59 months) (Bobossi‐Serengbe 2015).…”

Section: Resultsmentioning

confidence: 99%

“…Only two trials reported duration of hospital stay (Aguwa 2010; Phu 2010); and two trials reported on the number of children requiring blood transfusions (Hien 1996; Olumese 1999). Twelve trials reported on adverse events including episodes of hypoglycaemia (Karbwang 1992; Walker 1993; Karbwang 1995; Hien 1996; Murphy 1996; van Hensbroek 1996; Seaton 1998; Adam 2002; Huda 2003; Minta 2005; Phu 2010; Bobossi‐Serengbe 2015). We have listed the outcome definitions used in the included trials in Table 13.…”

Section: Resultsmentioning

confidence: 99%

“…Parasite clearance was taken as adequate clinical and parasitological response (ACPR) at days 3 and 14. Parasite count taken on D0, D3 and D14.Not reportedBobossi‐Serengbe 2015Not reportedNot reportedProportions with parasite clearance on D3 and D7 reported but not defined.Not reportedHien 1996Median value (h) reported and defined as the time to reach a score of 15 on the Glasgow Coma ScaleMedian value (h) reported but not defined.Median value (h) reported and defined as the time passed from admission and start of treatment until 3 consecutive negative blood smears. Blood films repeated every 4 hours for the first 24 hours and then every 6 hours.Number of episodes (n/N) reported but not definedHuda 2003Glasgow coma scale was used in grading the level of consciousness of the patients every 8 hoursMean value (h) reported and defined as time to clearance of feverMean value (h) reported but not definedNot reportedKarbwang 1992Unclear if values reported are means or medians (h)Mean value (h) reported and defined as time for the temperature to fall below 37.5 °C and remain that value for 72 hoursMean value (h) reported and defined as the time for the parasite count to fall below the level of microscopic detection (thick film)Not reportedKarbwang 1995Median value (h) reported and defined as the time taken for the patients to recover completely from unconciousnessMean value (h) reported and defined as time for the temperature to fall below 37.5 °C and remain that value for 72 hoursMedian value (h) reported and defined as the time taken for parasite count to fall below the level of microscopic detection (thick film)Not reportedMinta 2005Mean value (h) reported and defined as the time to normalization of consciousnessMean value (h) reported but not definedMean value (h) reported and defined as time till negative parasitaemia resultNot reportedMurphy 1996Median value (h) reported but not describedMedian value (h) reported but not describedMedian value (h) reported but not described.…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Artemether for severe malaria

Esu

Effa

Opie

et al. 2019

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

* The assumed risk is the m edian control group risk across studies. The corresponding risk (and its 95% CI) is based on the assum ed risk in the com parison group and the relative effect of the intervention (and its 95% CI). CI: Conf idence interval; RR: Risk ratio. GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our conf idence in the estim ate of ef f ect. M oderate quality: Further research is likely to have an im portant im pact on our conf idence in the estim ate of ef f ect and m ay change the estim ate. Low quality: Further research is very likely to have an im portant im pact on our conf idence in the estim ate of ef f ect and is likely to change the estim ate. Very low quality: We are very uncertain about the estim ate. 1 No serious risk of bias: Trials were variable in their risk of bias, but exclusion of the trials at high or unclear risk of selection bias did not change this result. 2 No serious inconsistency: None of the individual trials f ound statistically signif icant ef f ects, and there was no statistical heterogeneity between trials. 3 No serious indirectness: Trials were f rom West Af rica, East Af rica and one f rom India. All were in children with severe m alaria (aged under 15 years), and m ost com pared the standard dose of intram uscular artem ether with the WHO recom m ended dose of intravenous quinine. 4 Downgraded by 1 f or serious im precision: These trials, and the overall m eta-analysis are underpowered to detect a dif f erence or to prove equivalence. 5 Downgraded by 2 f or serious risk of bias: Four of the six trials were at unclear risk of selection bias. When these f our trials are excluded the result becom es non-signif icant. 6 No serious inconsistency: Statistically signif icant dif f erences were only seen in two of the six trials. However, statistical heterogeneity between trials was low and the overall m eta-analysis is statistically signif icant. 7 No serious im precision: The result is statistically signif icant and the overall m eta-analysis is adequately powered to detect this ef f ect. 8 Downgraded by 2 f or very serious im precision: These trials, and the overall m eta-analysis are underpowered to detect a dif f erence or to prove equivalence. The 95% CI is very wide and includes clinically im portant dif f erences and no ef f ect. 9 Downgraded by 1 f or serious inconsistency: The m ean dif f erence in parasite clearance tim e ranged f rom a two hour increase with artem ether to a 15 hour decrease. 10 Downgraded by 1 f or serious risk of bias: Four of the seven trials were at unclear risk of selection bias. When these f our trials are excluded the result becom es non-signif icant.

show abstract

“…Of these, there was only one potentially eligible article. This new study met the inclusion criteria (Bobossi‐Serengbe 2015).…”

Section: Resultsmentioning

confidence: 99%

“…In this review update, we included one additional RCT enrolling 212 participants (children aged between six and 59 months) (Bobossi‐Serengbe 2015).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Artemether for severe malaria

Esu

Effa

Opie

et al. 2019

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

“…However, despite efforts to control malaria through multiple schemes coordinated by the National Malaria Control Program (NMCP), malaria continues to be the major public health problem according to the scientific literature and the CAR country profile in the World Malaria Report. In 2010, two studies showed prevalence rates of 65.8% and 64.9%, respectively, in children at the Bangui Pediatric Complex (CPB) and in pregnant women in the Ouham-Pendé Prefecture [8,9].…”

Section: Introductionmentioning

confidence: 99%

Falciparum Malaria in Febrile Patients at Sentinel Sites for Influenza Surveillance in the Central African Republic from 2015 to 2018

Nzoumbou‐Boko

Yambiyo

Ngoagouni

et al. 2020

Interdisciplinary Perspectives on Infectious Diseases

View full text Add to dashboard Cite

Malaria is a major public health issue in the Central African Republic (CAR) despite massive scale-up of malaria interventions. However, no information is available on the incidence of malaria in febrile illness cases or on the distribution of malaria infection according to demographic characteristics, which are important indicators and valuable epidemiological surveillance tools. This study therefore aimed to characterize malaria in the network of sentinel sites set up for influenza surveillance. A retrospective analysis was conducted to explore the data from these sentinel sites from 2015 to 2018. The Paracheck-Pf® rapid diagnosis test kit was used to screen for malaria in febrile illness cases. A total of 3609 malaria cases were identified in 5397 febrile patients, giving an incidence rate of 66.8%. The age group of 1–4 years was the most affected by malaria (76.0%). Moreover, prevalence varied across different sentinel sites, with the Bossembele Health Center, located in a rural area, showing an incidence of 96%, the Saint Joseph Health Center in a semiurban area of Bangui showing an incidence of 75%, and the Bangui Pediatric Complex in an urban site with an incidence of only 44.6%. Malaria transmission was holoendemic over the four-year study period, and malaria incidence decreased from 2016 to 2018. The incidence of malaria coinfection with influenza was 6.8%. This study demonstrated clear microspatial heterogeneity of malaria. Malaria was consistently the most frequent cause of febrile illness. Including sites in different climate zones in the CAR will allow for a more representative study.

show abstract