Comparación de las concentraciones de vitamina D por 3 métodos comerciales

Álvarez, Eva María Iglesias; Ybern, María Luisa Granada; Botias, María Doladé; Osaba, Jaume Barallat Martínez de; Sáez, Isabel Hidalgo; Ferrer, María Cruz Pastor

doi:10.1016/j.labcli.2012.05.003

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…Saleh et al found an intraassay CV < 6,6% an interassay CV < 9,2% [ 20 ] and in the study carried out by Kocak FE et al [ 21 ] the intraassay CVs were 4.2% for low, 2.7% for medium and 2.2% for high level). The intra-assay CV obtained by Iglesias Álvarez et al was <3.7% [ 22 ] and as in our study, and M. K. Kaoivula et al found a coefficient of variation greater for Vitro than for Abbott (CV 6.2–16.9% and 3.8–4.6% for low control and CV 5.4–8.9% and 2.8% for high control, respectively [ 23 ]).…”

Section: Discussionsupporting

confidence: 84%

Comparative study of two immunoassays used for the determination of serum vitamin D

Lahoz

Sánchez

Górriz

et al. 2021

Practical Laboratory Medicine

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Objectives The best indicator of vitamin D level is the determination of serum 25-hydroxyvitamin D (25(OH)D). Due to the lack of standardization of the available methods, there are problems of precision and reproducibility in its measurement. The objective of this study was to compare the results of 25(OH)D concentration determined by two different immunoassay methods. Design and Methods: 25(OH)D was analyzed in 184 serum samples in an IDS-iSYS Multi-Discipline Automated System Analyzer (Vitro) and in an Alinity i automated Analyzer (Abbott). Then, results were compared. Three groups were considered: group of total patients, group with vitamin D supplements and group without treatment. Results Of the total patients, 52.7% received vitamin D supplements. The correlation coefficient of agreement for general group, supplementation group and group without supplementation was 0.92, 0.91 and 0.89, respectively. In all of them, a kappa index>0.75 was obtained. Conclusions The assays evaluated are not comparable to each other. Despite this, they show an excellent concordance in the evaluation of the vitamin D status.

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Section: Discussionsupporting

confidence: 84%

Comparative study of two immunoassays used for the determination of serum vitamin D

Lahoz

Sánchez

Górriz

et al. 2021

Practical Laboratory Medicine

View full text Add to dashboard Cite

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“…The 25(OH)D serum concentration was determined by an automated electro-chemiluminescent binding assay (Modular Analytics E170 and Elecsys Vitamin D Total II, Roche Diagnostics, GmBH (Manheim, Germany)), with a measurement range from 3 to 70 ng/dL. This test has previously been validated against liquid chromatography–tandem mass spectrometry (LC/MS/MS), and it has been certified by the CDC Vitamin D Standardization-Certification Program (VDSCP) [ 18 , 19 , 20 , 21 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

Vitamin D Deficiency and Gestational Diabetes Mellitus in Relation to Body Mass Index

et al. 2021

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A relationship between vitamin D deficiency (VDD) and gestational diabetes mellitus (GDM) has been described. Considering that GDM prevalence depends on body mass index (BMI), our main objective was to determine if VDD is associated with GDM, independent of BMI. A cross-sectional study with 886 pregnant women was conducted in Elda (Spain) from September 2019 to June 2020. To assess the association, Poisson regression models with robust variance were used to estimate the prevalence ratio (PR). The observed GDM prevalence was 10.5%, while the VDD prevalence was 55.5%. In the crude model, both VDD and obesity were associated with GDM, but in the adjusted model, only VDD was statistically significant (PR = 1.635, p = 0.038). A secondary event analysis did not detect differences in VDD, but BMI yielded a higher frequency of births by cesarean section and newborns with a >90 percentile weight in the obesity group. In conclusion, VDD is associated with GDM, independent of BMI. Future longitudinal studies could provide information on causality.

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“…The serum 25(OH)D concentration was measured by an electrochemiluminescent automated binding assay (Modular Analytics E170 and Elecsys Vitamin D Total II, Roche Diagnostics, GmBH (Manheim, Germany)), with a measuring range from 3 to 70 ng/mL. This assay has been previously validated by liquid chromatography-tandem mass spectrometry (LC/MS/MS), and has been accredited by the Vitamin D Standardisation and Certification Program (VDSCP) of the CDC [19][20][21][22][23]. VDD was established as a serum concentration <20 ng/mL [8,24].…”

Section: Evaluation Of Vitamin D Levelsmentioning

confidence: 99%

Influence of Strict Lockdown on Vitamin D Deficiency in Pregnant Women: A Word of Caution

et al. 2023

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The main source of vitamin D results from skin sunlight exposure. Vitamin D deficiency (VDD) is linked to several adverse events during pregnancy. While performing a cross-sectional study with 886 pregnant women in Elda (Spain) from September 2019 to July 2020 to determine the association of VDD with gestational diabetes mellitus in relation to body mass index, a strict lockdown (SL) due to the COVID-19 pandemic was declared from 15 March 2020 to 15 May 2020. To determine if VDD prevalence in the local population of pregnant women was influenced by SL, a retrospective cross-sectional study was conducted to estimate the prevalence odds ratio (POR) for the association of VDD and SL. A crude logistic regression model was calculated, and then further adjusted by the biweekly measured vitamin D-specific UVB dose in our geographical area. The POR during SL was 4.0 (95%CI = 2.7–5.7), with a VDD prevalence of 77.8% in the quarantine period. Our results revealed that VDD prevalence in pregnant women was influenced by SL. This valuable information could guide us in future if public officials order the population to stay indoors for any given reason.

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Comparación de las concentraciones de vitamina D por 3 métodos comerciales

Cited by 4 publications

References 16 publications

Comparative study of two immunoassays used for the determination of serum vitamin D

Comparative study of two immunoassays used for the determination of serum vitamin D

Vitamin D Deficiency and Gestational Diabetes Mellitus in Relation to Body Mass Index

Influence of Strict Lockdown on Vitamin D Deficiency in Pregnant Women: A Word of Caution

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