Comparação dos efeitos de sulfato de magnésio e da dexmedetomidina sobre a qualidade da visibilidade em cirurgia endoscópica sinusal: estudo clínico randomizado

Abstract

Due to its reduction of bleeding and heart rate in endoscopic sinus surgery and its positive impacts on the duration of surgery, we consider dexmedetomidine to be a good alternative to magnesium.

Comparison of effects and safety in providing controlled hypotension during surgery between dexmedetomidine and magnesium sulphate: A meta-analysis of randomized controlled trials

“…And then 4 studies were excluded by full-text review for they were performed in pediatric patients. At last, 10 RCTs were enrolled in further meta-analysis [14][15][16][17][18][19][20][21][22][23]. The identification procedure of these eligible articles is described in Fig 1. The enrolled studies were published from 2011 to 2018, and all of them were published in English.…”

“…A total of 663 patients were randomized to receive two drugs. In 10 included RCTs, 5 were researches about head and neck surgery [14][15][16][17][18], 3 were researches about spinal surgery [19][20][21], and the rest two trials were researches about pituitary adenoma surgery [22] and laparoscopic colorectal resection surgery [23]. All enrolled studies reported the hemodynamic parameters (MAP, HR), and 6 studies reported the evaluation of surgical field bleeding by using 6-point scale [14][15][16][17][18]22].…”

“…In 10 included RCTs, 5 were researches about head and neck surgery [14][15][16][17][18], 3 were researches about spinal surgery [19][20][21], and the rest two trials were researches about pituitary adenoma surgery [22] and laparoscopic colorectal resection surgery [23]. All enrolled studies reported the hemodynamic parameters (MAP, HR), and 6 studies reported the evaluation of surgical field bleeding by using 6-point scale [14][15][16][17][18]22]. Duration of surgery was reported in 8 studies [14][15][16][17][18][21][22][23], and the number of patients requiring opioid/analgesia administration was reported in 3 studies [14,16,18].…”

“…All enrolled studies reported the hemodynamic parameters (MAP, HR), and 6 studies reported the evaluation of surgical field bleeding by using 6-point scale [14][15][16][17][18]22]. Duration of surgery was reported in 8 studies [14][15][16][17][18][21][22][23], and the number of patients requiring opioid/analgesia administration was reported in 3 studies [14,16,18]. The recovery profile of patients was measured by the time till reaching Aldrete score �9 in 5 studies [14,[16][17][18]23].…”

“…The mentioned-above seven aspects including random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome data, selective reporting and other bias of selected RCTs were evaluated according to the Cochrane Collaboration tool. Seven studies used an adequate method of random sequence generation [14][15][16]19,20,21,22], and four studies [16,19,20,23] employed allocation concealment by using the opaque, sealed envelopes. Seven studies mentioned the blinding procedure of participants and personnel [14,[16][17][18]21,22] and the blinding procedure of outcome assessment was performed appropriately in four studies [14,[16][17][18].…”