Comparação do efeito antiangiogênico do ranibizumab e do bevacizumab in vitro

Souto, Alexandre Cupello; Maricato, Juliana Terzi; Denapoli, Priscila Martins Andrade; Sallum, Juliana Maria Ferraz; Han, Sang Won

doi:10.1590/s0004-27492011000500006

Cited by 2 publications

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“…A terapia antiangiogênica consiste no bloqueio da angiogênese por meio de drogas inibidoras do fator de crescimento vascular endotelial (VEGF) (13) . A ranibizumabe e bevacisumabe bloqueiam todas as isoformas do VEGF e o pegaptanibe atua sobre a isoforma 165 (102) . A injeção intravítrea dessas drogas tem sido objeto de vários estudos e atualmente o ranibizumabe é utilizado em injeções mensais por 3 meses com aplicações adicionais baseadas em critérios clínicos e na OCT (104) .…”

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que em meio a tantas dificuldades na vida, me conduziram até aqui. Ao Denis, pela paciência e dedicação e a Caroline pelo amor incondicional. A meus irmãos, em especial ao querido Júlio, pelo apoio e orações. À minha sogra, Sra. Júlia, que muito contribuiu com sua sabedoria. viii ix AGRADECIMENTOS A Deus em primeiro lugar, por tão grandiosa bênção concedida a mim em todas as áreas da minha vida, a Ele a Glória e a Honra para sempre, amém! À Prof.ª Dra. Antonia Paula Marques de Faria, pelo exemplo de dedicação ao ensino, confiança e tempo despendido na orientação deste estudo. Ao Prof. Dr. Luis Alberto Magna pelo carinho e esmero na análise dos dados estatísticos deste trabalho. Ao Prof. Dr. Carlos Eduardo Leite Arieta, pelo exemplo e apoio, sobretudo pela amizade. Ao Prof. Newton Kara José, pela constante motivação e exemplo de dedicação à pesquisa científica. À Prof. a Aos doutores Andrea Torigoe, Maurício Nascimento, Mônica Barbosa Melo e Fábio Hirata pela imensa colaboração para a realização deste estudo.Dra. Keila Monteiro de Carvalho, por sua amizade e dedicação ao curso de pós-graduação.

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“…A PDT provoca a oclusão seletiva da MNVC por meio da injeção de corante (verteporfirina) via endovenosa e estimulada por laser específico de 650 ƞm (102) Há estudos em fase experimental utilizando RNA interference (RNAi)…”

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Neste fascículo do ABO

Chamon¹

2011

Arq. Bras. Oftalmol.

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This issue of ABO brings interesting articles in epidemiology, basic research, new technologies and randomized clinical trials.Kara-Júnior and his colleagues (1) presented the results of a questionnaire administered to more than 600 patients treated in a campaign to perform cataract surgery in São Paulo. The study showed a sad reality for patients excluded from the comprehensive eye care. Almost half of all patients interviewed were unable to gain access to cataract surgery before the campaign, because they have abandoned the free public service as a result of the long waiting lists or for failing to schedule their surgeries (19%), or did not have the resources to afford the costs associated with surgeries performed by health insurance or private care (29%). The costs reported by patients who had not sought public service ranged from R$ 1,000 to over R$ 4,000.00. Authors rightly emphasized in their conclusions "the need to continue to carry out community campaigns to meet people who would not have access to surgery by conventional means." I also believe it is important to consider that, despite the campaigns being indispensable at the present time the Brazilian public health, we must keep in mind that, ideally, access to health care should be possible for the whole population without the need to create specific campaigns.Patients with anophthalmic cavities were evaluated in two articles (2,3) . Narikawa and colleagues (2) retrospectively analyzed the epidemiological profile of 107 patients with anophthalmic cavity in a reference service in the state of São Paulo, detecting trauma as the most frequent etiology, especially in men. In another study conducted in the Federal District, Goulart and colleagues (3) assessed the psychosocial aspects involved in the rehabilitation of patients with anophthalmic cavity. In their study, which evaluated 44.4% of patients with anophthalmic cavity since 2004, the trauma was also nominated as the most frequent cause. In this sample, one third of patients said that the eye loss negatively influenced their daily routine.Several epidemiological, clinical and basic research articles focused on retinal aspects. In another epidemiological study, evaluating patients with sickle cell disease, Freitas and colleagues (4) demonstrated that routine eye examination may, in specific cases, establish clinical suspicion of systemic diseases. Gil and colleagues (5) conducted a randomized double-blind clinical trial to compare, through morphological and functional assessment, the treatment of diffuse diabetic macular edema with intravitreal triamcinolone and with laser phototherapy. Twenty-one eyes of 14 patients were randomly assigned to each group. Although intravitreal injection have led to the decrease in retinal thickness measured by OCT, the study showed no functional differences between the initial examination after three months of treatment in either group. In a study of basic research, evaluating a promising anti-inflammatory drug for intravitreal use, Rassi et al. (6) demonstrated that...

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Comparação do efeito antiangiogênico do ranibizumab e do bevacizumab in vitro

Cited by 2 publications

References 20 publications

Degeneração macular relacionada à idade

Degeneração macular relacionada à idade

Neste fascículo do ABO

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